Scientific Commons: Asato Kojima

All APOBEC3 family proteins differentially inhibit LINE-1 retrotransposition (2007)

Kinomoto, Masanobu, Kanno, Takayuki, Shimura, Mari, Ishizaka, Yukihito, Kojima, Asato, Kurata, Takeshi, ...

Approximately 17% of the human genome is comprised of long interspersed nuclear element 1 (LINE-1, L1) non-LTR retrotransposons. L1 retrotransposition is known to be the cause of several genetic...

Rapid and Simple Phenotypic Assay for Drug Susceptibility of Human Immunodeficiency Virus Type 1 Using CCR5-Expressing HeLa/CD4+ Cell Clone 1-10 (MAGIC-5)

Hachiya, Atsuko, Aizawa-Matsuoka, Saori, Tanaka, Mari, Takahashi, Yukiko, Ida, Setsuko, Gatanaga, Hiroyuki, ...

We describe a rapid and simple novel phenotypic assay for drug susceptibility of human immunodeficiency virus type-1 (HIV-1) using a CCR5-expressing HeLa/CD4+ cell clone 1-10 (MAGIC-5). MAGIC-5 cells...

Inhibition of Human Immunodeficiency Virus Type 1 Virion Entry by Dominant-Negative Hck

Tokunaga, Kenzo, Kiyokawa, Etsuko, Nakaya, Mie, Otsuka, Naomi, Kojima, Asato, Kurata, Takeshi, ...

To study the role of Src family tyrosine kinases in infection with human immunodeficiency virus type 1 (HIV-1), we constructed an Hck mutant, HckN, that hinders signaling from wild-type Hck. HIV-1...

Stable High-Producer Cell Clone Expressing Virus-Like Particles of the Japanese Encephalitis Virus E Protein for a Second-Generation Subunit Vaccine

Kojima, Asato, Yasuda, Atsushi, Asanuma, Hideki, Ishikawa, Toyokazu, Takamizawa, Akihisa, Yasui, Kotaro, ...

We produced and characterized a cell clone (J12#26 cells) that stably expresses Japanese encephalitis virus (JEV) cDNA, J12, which encodes the viral signal peptide, premembrane (prM), and envelope...

Impaired Processing and Presentation of Cytotoxic-T-Lymphocyte (CTL) Epitopes Are Major Escape Mechanisms from CTL Immune Pressure in Human Immunodeficiency Virus Type 1 Infection

Yokomaku, Yoshiyuki, Miura, Hideka, Tomiyama, Hiroko, Kawana-Tachikawa, Ai, Takiguchi, Masafumi, Kojima, Asato, ...

Investigating escape mechanisms of human immunodeficiency virus type 1 (HIV-1) from cytotoxic T lymphocytes (CTLs) is essential for understanding the pathogenesis of HIV-1 infection and developing...

Amino Acid 36 in the Human Immunodeficiency Virus Type 1 gp41 Ectodomain Controls Fusogenic Activity: Implications for the Molecular Mechanism of Viral Escape from a Fusion Inhibitor

Kinomoto, Masanobu, Yokoyama, Masaru, Sato, Hironori, Kojima, Asato, Kurata, Takeshi, Ikuta, Kazuyoshi, ...

We have previously described a human immunodeficiency virus type 1 (HIV-1) proviral clone, pL2, derived from defective viral particles with higher fusogenicity than the prototypic NL4-3 virus. In...

An Attenuated LC16m8 Smallpox Vaccine: Analysis of Full-Genome Sequence and Induction of Immune Protection§

Morikawa, Shigeru, Sakiyama, Tokuki, Hasegawa, Hideki, Saijo, Masayuki, Maeda, Akihiko, Kurane, Ichiro, ...

The potential threat of smallpox bioterrorism has made urgent the development of lower-virulence vaccinia virus vaccines. An attenuated LC16m8 (m8) vaccine was developed in 1975 from the Lister...