Astrid Dempfle

Meta-analysis of genome-wide linkage scans of attention deficit hyperactivity disorder (In Special Issue on the Genetics of ADHD Dedicated to the Memory of Richard Todd) (2008)

Zhou, Kaixin, Dempfle, Astrid, Arcos-Burgos, Mauricio, Bakker, Steven C., Banaschewski, Tobias, Biederman, Joseph, ...

Genetic contribution to the development of attention deficit hyperactivity disorder (ADHD) is well established. Seven independent genome-wide linkage scans have been performed to map loci that...

Comparison of the power of haplotype-based versus single- and multilocus association methods for gene × environment (gene × sex) interactions and application to gene × smoking and gene × sex interactions in rheumatoid arthritis (2007)

Dempfle, Astrid, Hein, Rebecca, Beckmann, Lars, Scherag, André, Nguyen, Thuy, Schäfer, Helmut, ...

Abstract Accounting for interactions with environmental factors in association studies may improve the power to detect genetic effects and may help identifying important environmental effect...

Gender-specific association of a functional coding polymorphism in the Neuropeptide S receptor gene with panic disorder but not with schizophrenia or attention-deficit/hyperactivity disorder. (2007)

Okamura, Naoe, Hashimoto, Kenji, Iyo, Masaomi, Shimizu, Eiji, Dempfle, Astrid, Friedel, Susann, ...

Panic disorder is a common anxiety disorder characterized by sudden and recurrent panic attacks. Previous studies have indicated significant genetic contributions and a susceptibility locus for panic...

Evaluation of methods for meta-analysis of genetic linkage studies for complex diseases and application to genome scans for asthma and adult height (2006)

Dempfle, Astrid

Linkage genome scans for genetically complex diseases have low power with the sample sizes that were often used in the past, and hence meta-analysis of several scans for the same disease might be a...

subsequent (2006)

Astrid Dempfle, Stefan A. Wudy, Kathrin Saar, Ra Hagemann, Susann Friedel, Lars D. Berthold, ...

Evidence for involvement of the vitamin D receptor gene in

Evidence for involvement of the vitamin D receptor gene in idiopathic short stature via a genome wide linkage study and subsequent association studies (2006)

Dempfle, Astrid, Wudy, Stefan A., Saar, Kathrin, Hagemann, Sandra, Friedel, Susann, Scherag, André, ...

Stature is a highly heritable trait under both polygenic and major gene control. We aimed to identify genetic regions linked to idiopathic short stature (ISS) in childhood, through a whole genome...

Evidence for involvement of the vitamin D receptor gene in idiopathic short stature via a genome-wide linkage study and subsequent association studies (2006)

Dempfle, Astrid, Wudy, Stefan A., Saar, Kathrin, Hagemann, Sandra, Friedel, Susann, Scherag, André, ...

Stature is a highly heritable trait under both polygenic and major gene control. We aimed to identify genetic regions linked to idiopathic short stature (ISS) in childhood, through a whole genome...

Genome scan for body mass index and height in the Framingham Heart Study (2003)

Geller, Frank, Dempfle, Astrid, Görg, Tilman

Abstract Background Body mass index (BMI) and adult height are moderately and highly heritable traits, respectively. To investigate the genetic background of these quantitative phenotypes, we...

Normalisation of gene-expression data 13 (2001)

Biometric Society, Anne Whitehead, Lutz Edler, Hans-peter Piepho, Astrid Dempfle, Sabine Loesgen, ...

Some approaches for mapping quqantitative trait loci (QTL) in plant breeding populations 12

Melanocortin-4 Receptor Gene Variant I103 Is Negatively Associated with Obesity

Geller, Frank, Reichwald, Kathrin, Dempfle, Astrid, Illig, Thomas, Vollmert, Caren, Herpertz, Stephan, ...

Several rare mutations in the melanocortin-4 receptor gene (MC4R) predispose to obesity. For the most common missense variant V103I (rs2229616), however, the previously reported similar carrier...

Genome scan for body mass index and height in the Framingham Heart Study

Geller, Frank, Dempfle, Astrid, Görg, Tilman

Deletions in the genomes of fifteen inbred mouse lines and their possible implications for fat accumulation*

Schmitt, Armin O., Dempfle, Astrid, Brockmann, Gudrun A.

Copy number variants (CNVs) are pieces of genomic DNA of 1000 base pairs or longer which occur in a given genome at a different frequency than in a reference genome. Their importance as a source for...

Nonparametric estimation of a discontinuity in regression

Astrid Dempfle

Comparison of the power of haplotype-based versus single- and multilocus association methods for gene × environment (gene × sex) interactions and application to gene × smoking and gene × sex interactions in rheumatoid arthritis

Dempfle, Astrid, Hein, Rebecca, Beckmann, Lars, Scherag, André, Nguyen, Thuy Trang, Schäfer, Helmut, ...

Accounting for interactions with environmental factors in association studies may improve the power to detect genetic effects and may help identifying important environmental effect modifiers. The...