Hypertrophic Cardiomyopathy, Jeanne James, Yan Zhang, Hanna Osinska, Atsushi Sanbe, Raisa Klevitsky, ...
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Chu, Guoxiang, Carr, Andrew N., Young, Karen B., Lester, J.William, Yatani, Atsuko, Sanbe, Atsushi, ...
Objective: Impaired myocyte Ca2+ handling is a common characteristic of failing hearts and increases in calcineurin activity, a Ca2+-sensitive phosphatase, have been implicated in heart failure...
PKA-dependent phosphorylation of cardiac myosin binding protein C in transgenic mice (2001)
Yang, Qinglin, Hewett, Timothy E., Klevitsky, Raisa, Sanbe, Atsushi, Wang, Xuejun, Robbins, Jeffrey
Objective: To investigate the physiological role of cAMP-dependent protein kinase A (PKA)-mediated, cardiac myosin binding protein C (MyBP-C) phosphorylation. Methods: A cardiac MyBP-C cDNA lacking...
Desmin-related cardiomyopathy in transgenic mice: A cardiac amyloidosis
Sanbe, Atsushi, Osinska, Hanna, Saffitz, Jeffrey E., Glabe, Charles G., Kayed, Rakez, Maloyan, Alina, ...
An R120G missense mutation in the small heat shock protein α-B-crystallin (CryABR120G) causes desmin-related cardiomyopathy (DRM). DRM is characterized by the formation of aggregates containing...
Reversal of amyloid-induced heart disease in desmin-related cardiomyopathy
Sanbe, Atsushi, Osinska, Hanna, Villa, Chet, Gulick, James, Klevitsky, Raisa, Glabe, Charles G., ...
Amyloid oligomers, similar to the toxic entities found in Alzheimer's disease patients and in other amyloid-based diseases, are present in cardiomyocytes derived from human heart-failure patients and...
A Transgenic Rabbit Model for Human Troponin I-based Hypertrophic Cardiomyopathy
Sanbe, Atsushi, James, Jeanne, Tuzcu, Volkan, Nas, Selman, Martin, Lisa, Gulick, James, ...
Maloyan, Alina, Sanbe, Atsushi, Osinska, Hanna, Westfall, Margaret, Robinson, Dustin, Imahashi, Ken-ichi, ...
Tallini, Yvonne N., Ohkura, Masamichi, Choi, Bum-Rak, Ji, Guangju, Imoto, Keiji, Doran, Robert, ...
Genetically encoded sensor proteins provide unique opportunities to advance the understanding of complex cellular interactions in physiologically relevant contexts; however, previously described...
Desmin-related cardiomyopathy in transgenic mice: A cardiac amyloidosis
Sanbe, Atsushi, Osinska, Hanna, Saffitz, Jeffrey E., Glabe, Charles G., Kayed, Rakez, Maloyan, Alina, ...
An R120G missense mutation in the small heat shock protein α-B-crystallin (CryABR120G) causes desmin-related cardiomyopathy (DRM). DRM is characterized by the formation of aggregates containing...
Reversal of amyloid-induced heart disease in desmin-related cardiomyopathy
Sanbe, Atsushi, Osinska, Hanna, Villa, Chet, Gulick, James, Klevitsky, Raisa, Glabe, Charles G., ...
Amyloid oligomers, similar to the toxic entities found in Alzheimer's disease patients and in other amyloid-based diseases, are present in cardiomyocytes derived from human heart-failure patients and...
Tallini, Yvonne N., Ohkura, Masamichi, Choi, Bum-Rak, Ji, Guangju, Imoto, Keiji, Doran, Robert, ...
Genetically encoded sensor proteins provide unique opportunities to advance the understanding of complex cellular interactions in physiologically relevant contexts; however, previously described...
Yamaguchi, Fuminari, Sanbe, Atsushi, Takeo, Satoshi
Calcium transport activity of isolated cardiac sarcoplasmic reticulum (SR) including Ca2+ uptake and release is decreased in animals with chronic heart failure (CHF) following myocardial infarction....
Toyoshima, Hiroko, Nasa, Yoshihisa, Kohsaka, Yumi, Isayama, Yoko, Yamaguchi, Fuminari, Sanbe, Atsushi, ...
Characteristics of cyclic GMP- and cyclic AMP-mediated relaxation in aortic segments of rats with chronic heart failure (CHF) and the effects of chronic treatment with an angiotensin I converting...
Yamaguchi, Fuminari, Kawana, Ken-ichiro, Tanonaka, Kouichi, Kamano, Isamu, Igarashi, Takahiro, Gen, Eigyoku, ...
The effects of long-term treatment with trandolapril, an angiotensin I-converting enzyme inhibitor, on exercise capacity of rats with chronic heart failure (CHF) following coronary artery ligation...
Hiroyama, Masami, Aoyagi, Toshinori, Fujiwara, Yoko, Oshikawa, Sayuri, Sanbe, Atsushi, Endo, Fumio, ...
An analysis of arginine-vasopressin (AVP) V1a receptor-deficient (V1aR −/−) mice revealed that glucose homeostasis and lipid metabolism were altered in the mutant mice. Here, we used V1aR −/−...
Insulin hypersensitivity in mice lacking the V1b vasopressin receptor
Fujiwara, Yoko, Hiroyama, Masami, Sanbe, Atsushi, Aoyagi, Toshinori, Birumachi, Jun-ichi, Yamauchi, Junji, ...
We have reported that [Arg8]-vasopressin-stimulated insulin release is blunted in islet cells isolated from V1b receptor-deficient (V1bR−/−) mice. In this study, we used V1bR−/− mice to...