Type 2 diabetes, muscle strength, and impaired physical function: the tip of the iceberg? (2005)
Aihie-Sayer, Avan, Dennison, Elaine M., Syddall, Holly E., Gilbody, Helen J., Phillips, David I.W., Cooper, Cyrus
Fetal programming of body composition and musculoskeletal development (2005)
Aihie-Sayer, Avan, Cooper, Cyrus
The prevalence of obesity, sarcopenia and osteoporosis is rising and there is increasing interest in determinants operating in early life. Fetal programming is the phenomenon whereby alterations in...
Jordan, Kelsey M., Syddall, Holly E., Garnero, Patrick, Gineyts, Evelyne, Dennison, Elaine, Aihie-Sayer, Avan, ...
Objective: To investigate the association between biochemical markers of bone,cartilage and synovial turnover with the presence and severity of knee osteoarthritisin men. Methods: 176 men aged 59-70...
Aihie-Sayer, Avan, Syddall, Holly E., Dennison, Elaine M., Gilbody, Helen J., Duggleby, Sarah L., Cooper, Cyrus, ...
Background: Size in early life is related to adult body mass index, and early environmental influences have been proposed to have lifelong consequences for obesity. However, body mass index also...
Does sarcopenia originate in early life? Findings from the Hertfordshire cohort study (2004)
Aihie-Sayer, Avan, Syddall, Holly E., Gilbody, Helen J., Dennison, Elaine M., Cooper, Cyrus
Background: Sarcopenia is defined as the loss of skeletal muscle mass and strength with aging. Recent epidemiological studies have shown that men and women who grew less well in early life have lower...
Day, Ian N., Chen, Xiao-he, Gaunt, Tom R., King, Tabitha H.T., Voropanov, Anca, Ye, Shu, ...
Low rates of fetal and infant growth are associated with the metabolic syndrome and cardiovascular disease in later life. We investigated common genetic variation in the GH-CSH gene cluster on...
Is grip strength a useful single marker of frailty? (2003)
Syddall, Holly, Cooper, Cyrus, Martin, Finbarr, Briggs, Roger, Aihie-Sayer, Avan
Background: chronological age is widely used as a marker of frailty in clinical practice. However there can be wide variation in frailty between individuals of a similar age. Grip strength is a...
Poole, Jason, Aihie-Sayer, Avan, Hardy, Rebecca, Wadsworth, Michael, Kuh, Diana, Cooper, Cyrus
Objective: To characterize the pattern of involvement of osteoarthritis (OA) of the hand among men and women of the same age. Methods: Structured hand examinations were performed on 1,467 men and...
Polymorphism of the IGF2 gene, birth weight and grip strength in adult men (2002)
Aihie-Sayer, Avan, Syddall, Holly, O'Dell, Sandra D., Chen, Xiao-He, Briggs, Patricia J., Briggs, R., ...
BACKGROUND: Grip strength is a simple measure of skeletal muscle function but a powerful predictor of disability, morbidity and mortality. Recent evidence has shown that prenatal and infant growth...
The early environment, developmental plasticity and aging (2002)
Aihie-Sayer, Avan, Barker, David
Darwin described how animal populations have two adaptation strategies: natural selection based on genetic variation acting over many generations, and developmental plasticity acting within the...
Kuh, Diana, Bassey, Joan, Hardy, Rebecca, Aihie-Sayer, Avan, Wadsworth, Michael, Cooper, Cyrus
Environmental influences during gestation may have long-term effects on adult muscle strength. It is not known how early in adult life such effects are manifest and whether they are modified by...
Prenatal exposure to a maternal low protein diet shortens life span in rats (2001)
Aihie-Sayer, Avan, Dunn, Rebecca, Langley-Evans, Simon, Cooper, Cyrus
Background: Postweaning diet restriction is associated with prolongation of life span, reduced age-related disease and slower ageing. The effects of diet restriction imposed prior to weaning have not...