Syddall, Holly, Evandrou, Maria, Cooper, Cyrus, Sayer, Avan Aihie
Objectives: To explore social inequalities in grip strength, SF-36 physical functioning (PF), and falls among older people. Methods: We analyzed data from 3,225 men and women (age 59-73 years) who...
Dennison, Elaine M., Syddall, Holly E., Jameson, Karen A., Sayer, Avan Aihie, Gaunt, Tom R., Rodriguez, Santiago, ...
Objective: we sought evidence of association of candidate single nucleotide polymorphisms (SNP) within the growth hormone-insulin-like growth factor 1 (IGF1) axis, largely selected on the basis of...
Finucane, Francis M., Horton, Jessica, Purslow, Lisa R., Savage, David B., Brage, Soren, Besson, Hervé, ...
Background: while there are compelling observational data confirming that individuals who exercise are healthier, the efficacy of aerobic exercise interventions to reduce metabolic risk and improve...
Robinson, Siân, Syddall, Holly, Jameson, Karen, Batelaan, Sue, Martin, Helen, Dennison, Elaine M., ...
Background: dietary patterns analysis takes account of the combined effects of foods and may be a more meaningful way of assessing dietary exposure than considering individual nutrients. Little is...
Costello, Paula M., Rowlerson, Anthea, Astaman, Nur Aida, Anthony, Fred Erick W., Sayer, Avan Aihie, Cooper, Cyrus, ...
Poor prenatal nutrition is associated with a greater risk of adult glucose intolerance and insulin insensitivity in the offspring. Skeletal muscle is the primary tissue for glucose utilization, and...
Batty, G. David, Smith, George Davey, Fall, Caroline H.D., Sayer, Avan Aihie, Dennison, Elaine, Cooper, Cyrus, ...
BACKGROUND: There is a suggestion that acute dehydration in childhood may lead to elevated blood pressure. We examined if episodes of diarrhoea in childhood, a recognized proxy for acute dehydration,...
Readiness of elders to use assistive devices to maintain their independence in the home (2007)
Pain, Helen, Gale, Catharine R, Watson, Clare, Cox, Vanessa, Cooper, Cyrus, Sayer, Avan Aihie
Grip strength, body composition, and mortality (2007)
Gale, Catharine R, Martyn, Christopher N, Cooper, Cyrus, Sayer, Avan Aihie
Background Several studies in older people have shown that grip strength predicts all-cause mortality. The mechanisms are unclear. Muscle strength declines with age, accompanied by a loss of muscle...
Schlotz, Wolff, Ambery, Phil, Syddall, Holly E., Crozier, Sarah R., Sayer, Avan Aihie, Cooper, Cyrus, ...
Insulin resistance is a metabolic abnormality that underlies Type 2 diabetes, the metabolic syndrome and cardiovascular disease, but it may also be associated with more global health deficits. This...
Alharbi, Khalid K., Spanakis, Emmanuel, Tan, Karen, Smith, Matt J., Aldahmesh, Mohammed A., O'Dell, Sandra D., ...
Identification of unknown mutations has remained laborious, expensive, and only viable for studies of selected cases. Population-based "reference ranges" of rarer sequence diversity are not...
Grip strength, body composition, and mortality (2007)
Gale, Catharine R., Martyn, Christopher N., Cooper, Cyrus, Sayer, Avan Aihie
BACKGROUND: Several studies in older people have shown that grip strength predicts all-cause mortality. The mechanisms are unclear. Muscle strength declines with age, accompanied by a loss of muscle...
Batty, G David, Smith, George Davey, Fall, Caroline H D, Sayer, Avan Aihie, Dennison, Elaine, Cooper, Cyrus, ...
Background There is a suggestion that acute dehydration in childhood may lead to elevated blood pressure. We examined if episodes of diarrhoea in childhood, a recognized proxy for acute dehydration,...
Roberts, Helen C., Hemsley, Zoe M., Thomas, Gwen, Meakins, Philip, Powell, Jackie, Robison, Judy, ...
Objective: to determine the resources required to carry out the single assessment process in primary care. Design: prospective descriptive study. Setting: one urban primary care practice,...
Sayer, Avan Aihie, Syddall, Holly E, Martin, Helen J., Dennison, Elaine M., Roberts, Helen C., Cooper, Cyrus
Objective: to investigate the relationship between grip strength and health-related quality of life (HRQoL). Design: cross-sectional survey within a cohort study design. Setting: the county of...
Roberts, Helen C., Hemsley, Zoe M., Thomas, Gwen, Meakins, Philip, Powell, Jackie, Robison, Judy, ...
Objective: to determine the resources required to carry out the single assessment process in primary care. Design: prospective descriptive study. Setting: one urban primary care practice,...
Sayer, Avan Aihie, Syddall, Holly E., Martin, Helen J., Dennison, Elaine M., Roberts, Helen C., Cooper, Cyrus
Objective: to investigate the relationship between grip strength and health-related quality of life (HRQoL). Design: cross-sectional survey within a cohort study design. Setting: the county of...
Falls, Sarcopenia, and Growth in Early Life: Findings from the Hertfordshire Cohort Study (2006)
Sayer, Avan Aihie, Syddall, Holly E., Martin, Helen J., Dennison, Elaine M., Anderson, Frazer H., Cooper, Cyrus
Recent studies have shown that people whose early growth is poor have an increased risk of sarcopenia. Sarcopenia is an important risk factor for falls, but it is not known whether poor early growth...
Developmental Origins of Midlife Physical Performance: Evidence from a British Birth Cohort (2006)
Kuh, Diana, Hardy, Rebecca, Butterworth, Suzanne, Okell, Lucy, Richards, Marcus, Wadsworth, Michael, ...
The authors hypothesized that 1) physical growth, as a marker of the early development of muscle fibers, and 2) advanced childhood motor and cognitive abilities, as markers of central nervous system...
Grip strength and length of stay (2006)
Sayer, Avan Aihie, Briggs, Roger, Turner, Gillian, Cooper, Cyrus, Syddall, Holly, Kerr, Alastair
Roberts, Helen C., Hemsley, Zoe M., Thomas, Gwen, Meakins, Philip, Powell, Jackie, Robinson, Judy, ...
Objective: To determine the resources required to carry out the single assessment process in primary care. Design: Prospective descriptive study. Setting: One urban primary care practice,...
Roberts, Helen C., Hemsley, Zoe M., Thomas, Gwen, Meakins, Philip, Powell, Jackie, Robison, Judy, ...
Objective: To determine the resources required to carry out the Single Assessment Process in primary care. Design: Prospective descriptive study. Setting: One urban primary care practice,...
Sayer, Avan Aihie, Syddall, Holly E., Martin, Helen J., Dennison, Elaine M., Roberts, Helen C., Cooper, Cyrus
Objective: To investigate the relationship between grip strength and health-related quality of life (HRQoL). Design: Cross-sectional survey within a cohort study design. Setting: The county of...
Grip strength, body composition, and mortality (2006)
Gale, Catharine R., Martyn, Christopher N., Cooper, Cyrus, Sayer, Avan Aihie
Background Several studies in older people have shown that grip strength predicts all-cause mortality. The mechanisms are unclear. Muscle strength declines with age, accompanied by a loss of muscle...
Gaunt, Tom R., Chen, Xiao-he, King, Tabitha H.T., Voropanov, Anca, Shu, Ye, Rodriguez, Santiago, ...
Polymorphism of the IGF2 gene, birth weight and grip strength in adult men (2002)
Sayer, Avan Aihie, Syddall, Holly, O'Dell, Sandra D., Chen, Xiao-he, Briggs, Patricia J., Briggs, R., ...
BACKGROUND: Grip strength is a simple measure of skeletal muscle function but a powerful predictor of disability, morbidity and mortality. Recent evidence has shown that prenatal and infant growth...
Insulin-like growth factor-I genotype and birthweight (2002)
Day, Ian N.M., King, Tabitha H.T., Chen, Xiao-he, Voropanov, Anca M., Ye, Shu, Syddall, Holly E., ...
O'Dell, Sandra D., Syddall, Holly E., Sayer, Avan Aihie, Cooper, Cyrus, Fall, Caroline H.D., Dennison, Elaine M., ...
Ciliary neurotrophic factor (CNTF) administration reduces weight in leptin-resistant mice via the signalling pathway normally activated by leptin. A G>A null mutation in the CNTF gene results in...
Polymorphism of the IGF2 gene, birth weight and grip strength in adult men (2002)
Sayer, Avan Aihie, Syddall, Holly, O'Dell, Sandra D., Chen, Xiao-he, Briggs, Patricia J., Briggs, R., ...
Background: grip strength is a simple measure of skeletal muscle function but a powerful predictor of disability, morbidity and mortality. Recent evidence has shown that prenatal and infant growth...
Are rates of ageing determined in utero? (1998)
SAYER, AVAN AIHIE, COOPER, CYRUS, EVANS, JENNIFER R., RAUF, ABDUL, WORMALD, RICHARD P. L, OSMOND, CLIVE, ...
Background: epidemiological studies have shown that poor early growth is associated with cardiovascular and other degenerative diseases. This has been explained by programming, whereby undernutrition...
Aging and its relationship to early growth. (1997)
Thesis (Ph. D.)--University of Southampton, 1997.
Growth in early life predicts bone strength in late adulthood: The Hertfordshire Cohort Study
Oliver, Helen, Jameson, Karen A., Sayer, Avan Aihie, Cooper, Cyrus, Dennison, Elaine M.
Infant growth is a determinant of adult bone mass, and poor childhood growth is a risk factor for adult hip fracture. Peripheral quantitative computed tomography (pQCT) allows non-invasive assessment...
Costello, Paula M, Rowlerson, Anthea, Astaman, Nur Aida, Anthony, Fred Erick W, Sayer, Avan Aihie, Cooper, Cyrus, ...
Poor prenatal nutrition is associated with a greater risk of adult glucose intolerance and insulin insensitivity in the offspring. Skeletal muscle is the primary tissue for glucose utilization, and...
Harwood, Rowan H., Sayer, Avan Aihie, Hirschfeld, Miriam
OBJECTIVE: To estimate the number of people worldwide requiring daily assistance from another person in carrying out health, domestic or personal tasks. METHODS: Data from the Global Burden of...