Inhibition of Aurora-kinases for tailored risk adapted treatment of multiple myeloma. (2009)
Hose, Dirk, Rème, Thierry, Meissner, Tobias, Moreaux, Jerome, Seckinger, Anja, Lewis, Joe, ...
Genetic instability and cellular proliferation have been associated with Aurora-kinase expression in several cancer entities, including multiple myeloma. Therefore, the expression of Aurora-A, -B and...
Inhibition of Aurora-kinases for tailored risk adapted treatment of multiple myeloma. (2009)
Hose, Dirk, Rème, Thierry, Meissner, Tobias, Moreaux, Jerome, Seckinger, Anja, Lewis, Joe, ...
Genetic instability and cellular proliferation have been associated with Aurora-kinase expression in several cancer entities, including multiple myeloma. Therefore, the expression of Aurora-A, -B and...
Inhibition of Aurora-kinases for tailored risk adapted treatment of multiple myeloma. (2009)
Hose, Dirk, Rème, Thierry, Meissner, Tobias, Moreaux, Jerome, Seckinger, Anja, Lewis, Joe, ...
Genetic instability and cellular proliferation have been associated with Aurora-kinase expression in several cancer entities, including multiple myeloma. Therefore, the expression of Aurora-A, -B and...
penalizedSVM: a R-package for feature selection SVM classification (2009)
Becker, Natalia, Werft, Wiebke, Toedt, Grischa, Lichter, Peter, Benner, Axel
Summary: Support vector machine (SVMs) classification is a widely used and one of the most powerful classification techniques. However, a major limitation is that SVM cannot perform automatic gene...
Westermann, Frank, Muth, Daniel, Benner, Axel, Bauer, Tobias, Henrich, Kai-Oliver, Oberthuer, André, ...
Abstract Background Amplified MYCN oncogene resulting in deregulated MYCN transcriptional activity is observed in 20% of neuroblastomas and identifies a highly aggressive subtype. In MYCN single-copy...
Off-target effects of siRNA specific for GFP (2008)
Tschuch, Cordula, Schulz, Angela, Pscherer, Armin, Werft, Wiebke, Benner, Axel, Hotz-Wagenblatt, Agnes, ...
Abstract Background Gene knock down by RNAi is a highly effective approach to silence gene expression in experimental as well as therapeutic settings. However, this widely used methodology entails...
Jakubowska, Anna, Gronwald, Jacek, Menkiszak, Janusz, Górski, Bohdan, Huzarski, Tomasz, Byrski, Tomasz, ...
Abstract Background The variable penetrance of ovarian cancer in BRCA1 mutation carriers suggests that other genetic or environmental factors modify disease risk. The C to T transition in the 3'...
Jakubowska, Anna, Menkiszak, Janusz, Gorski, Bohdan, Huzarski, Tomasz, Byrski, Tomasz, Benner, Axel, ...
Background: The variable penetrance of ovarian cancer in BRCA1 mutation carriers suggests that other genetic or environmental factors modify disease risk. The C to T transition in the 3' untranslated...
Renner, Marcus, Bergmann, Gaby, Krebs, Inge, End, Caroline, Lyer, Stefan, Hilberg, Frank, ...
BACKGROUND & AIMS: Impaired mucosal defense plays an important role in the pathogenesis of Crohn's disease (CD), one of the main subtypes of inflammatory bowel disease (IBD). Deleted in malignant...
Pfister, Stefan, Schlaeger, Christof, Mendrzyk, Frank, Wittmann, Andrea, Benner, Axel, Kulozik, Andreas, ...
Existing microarray-based approaches for screening of DNA methylation are hampered by a number of shortcomings, such as the introduction of bias by DNA copy-number imbalances in the test genome and...
Pfister, Stefan, Schlaeger, Christof, Mendrzyk, Frank, Wittmann, Andrea, Benner, Axel, Kulozik, Andreas, ...
Existing microarray-based approaches for screening of DNA methylation are hampered by a number of shortcomings, such as the introduction of bias by DNA copy-number imbalances in the test genome and...
Deichmann, Martin, Thome, Marianne, Benner, Axel, Kirschner, Martin, Hassanzadeh, Judith, Kurzen, Hjalmar
Abstract Background Downstream of Ras, the serine/threonine kinase B-raf has been reported to be mutated, among other carcinomas, in a substantial subset of primary melanomas with a preponderance of...
Capillary electrophoretic analysis of genomic DNA methylation levels (2003)
Stach, Dirk, Schmitz, Oliver J., Stilgenbauer, Stephan, Benner, Axel, Döhner, Hartmut, Wiessler, Manfred, ...
Changes in DNA methylation have been found in the large majority of tumors. This phenomenon includes both genome‐wide hypomethylation and gene‐ specific hypermethylation. However, the...
Koesters, Robert, Hans, Margrit A., Benner, Axel, Prosst, Rüdiger, Boehm, Johannes, Gahlen, Johannes, ...
Constitutive activation of the wnt-signaling pathway plays an important role during both human and rat colon carcinogenesis and can be brought through mutations in either the adenomatous polyposis...
Capillary electrophoretic analysis of genomic DNA methylation levels
Stach, Dirk, Schmitz, Oliver J., Stilgenbauer, Stephan, Benner, Axel, Döhner, Hartmut, Wiessler, Manfred, ...
Changes in DNA methylation have been found in the large majority of tumors. This phenomenon includes both genome-wide hypomethylation and gene- specific hypermethylation. However, the clinical...
Deichmann, Martin, Thome, Marianne, Benner, Axel, Kirschner, Martin, Hassanzadeh, Judith, Kurzen, Hjalmar
Kienle, Peter, Koch, Moritz, Autschbach, Frank, Benner, Axel, Treiber, Martina, Wannenmacher, Michael, ...
Blood and bone marrow of 142 patients with or without preoperative chemoradiation for rectal cancer were tested for disseminated tumor cells. Preoperative chemoradiation was associated with a...
Capillary electrophoretic analysis of genomic DNA methylation levels
Stach, Dirk, Schmitz, Oliver J., Stilgenbauer, Stephan, Benner, Axel, Döhner, Hartmut, Wiessler, Manfred, ...
Changes in DNA methylation have been found in the large majority of tumors. This phenomenon includes both genome-wide hypomethylation and gene- specific hypermethylation. However, the clinical...
Deichmann, Martin, Thome, Marianne, Benner, Axel, Kirschner, Martin, Hassanzadeh, Judith, Kurzen, Hjalmar
Kienle, Peter, Koch, Moritz, Autschbach, Frank, Benner, Axel, Treiber, Martina, Wannenmacher, Michael, ...
Blood and bone marrow of 142 patients with or without preoperative chemoradiation for rectal cancer were tested for disseminated tumor cells. Preoperative chemoradiation was associated with a...
Pfister, Stefan, Schlaeger, Christof, Mendrzyk, Frank, Wittmann, Andrea, Benner, Axel, Kulozik, Andreas, ...
Existing microarray-based approaches for screening of DNA methylation are hampered by a number of shortcomings, such as the introduction of bias by DNA copy-number imbalances in the test genome and...
Gene Expression Patterns in Ependymomas Correlate with Tumor Location, Grade, and Patient Age
Korshunov, Andrey, Neben, Kai, Wrobel, Gunnar, Tews, Bjoern, Benner, Axel, Hahn, Meinhard, ...
To elucidate the molecular events responsible for tumorigenesis and progression of ependymomas, we analyzed molecular alterations on the gene expression level in a series of newly diagnosed ependymal...
Jakubowska, Anna, Gronwald, Jacek, Menkiszak, Janusz, Górski, Bohdan, Huzarski, Tomasz, Byrski, Tomasz, ...
Off-target effects of siRNA specific for GFP
Tschuch, Cordula, Schulz, Angela, Pscherer, Armin, Werft, Wiebke, Benner, Axel, Hotz-Wagenblatt, Agnes, ...
Schlenk, Richard F., Döhner, Konstanze, Kneba, Michael, Götze, Katharina, Hartmann, Frank, Del Valle, Francesco, ...
The findings of this study suggest that mutant NPM1, and more specifically the genotype mutant NPM1 without FLT3-ITD, is a predictive factor for response to all-trans retinoic acid given as an...
Westermann, Frank, Muth, Daniel, Benner, Axel, Bauer, Tobias, Henrich, Kai-Oliver, Oberthuer, André, ...
Differences in MYCN/c-MYC target gene expression are associated with distinct neuroblastoma subtypes and clinical outcome.