Axel Roers

Multiple sclerosis: Brain-infiltrating CD8(+) T cells persist as clonal expansions in the cerebrospinal fluid and blood (2004)

Skulina,Christian, Schmidt,Stephan, Dornmair,Klaus, Babbe,Holger, Roers,Axel, Rajewsky,Klaus, ...

Multiple sclerosis: Brain-infiltrating CD8(+) T cells persist as clonal expansions in the cerebrospinal fluid and blood (2004)

Skulina, Christian, Schmidt, Stephan, Dornmair, Klaus, Babbe, Holger, Roers, Axel, Rajewsky, Klaus, ...

MxA-Genexpression als Marker für endogenes Interferon / (1992)

Roers, Axel.

Freiburg (Breisgau), Univ., Diss. : 1994.

Clonal tracking of autoaggressive T cells in polymyositis by combining laser microdissection, single-cell PCR, and CDR3-spectratype analysis

Hofbauer, Monika, Wiesener, Solveigh, Babbe, Holger, Roers, Axel, Wekerle, Hartmut, Dornmair, Klaus, ...

Clonal expansions of CD8+ T cells have been identified in muscle and blood of polymyositis patients by PCR techniques, including T cell receptor (TCR) complementarity-determining region (CDR)3 length...

Multiple sclerosis: Brain-infiltrating CD8+ T cells persist as clonal expansions in the cerebrospinal fluid and blood

Skulina, Christian, Schmidt, Stephan, Dornmair, Klaus, Babbe, Holger, Roers, Axel, Rajewsky, Klaus, ...

We surveyed the T cell receptor repertoire in three separate compartments (brain, cerebrospinal fluid, and blood) of two multiple sclerosis patients who initially had diagnostic brain biopsies to...

Clonal tracking of autoaggressive T cells in polymyositis by combining laser microdissection, single-cell PCR, and CDR3-spectratype analysis

Hofbauer, Monika, Wiesener, Solveigh, Babbe, Holger, Roers, Axel, Wekerle, Hartmut, Dornmair, Klaus, ...

Clonal expansions of CD8+ T cells have been identified in muscle and blood of polymyositis patients by PCR techniques, including T cell receptor (TCR) complementarity-determining region (CDR)3 length...

Multiple sclerosis: Brain-infiltrating CD8+ T cells persist as clonal expansions in the cerebrospinal fluid and blood

Skulina, Christian, Schmidt, Stephan, Dornmair, Klaus, Babbe, Holger, Roers, Axel, Rajewsky, Klaus, ...

We surveyed the T cell receptor repertoire in three separate compartments (brain, cerebrospinal fluid, and blood) of two multiple sclerosis patients who initially had diagnostic brain biopsies to...

Single-Cell PCR Analysis of T Helper Cells in Human Lymph Node Germinal Centers

Roers, Axel, Hansmann, Martin Leo, Rajewsky, Klaus, Küppers, Ralf

The T helper cell population of human lymph node germinal centers (GCs) was analyzed for clonality and signs of antigen selection. Frozen sections of lymph node biopsies taken from three different...

CD8+ T Cells in Hodgkin’s Disease Tumor Tissue Are a Polyclonal Population with Limited Clonal Expansion but Little Evidence of Selection by Antigen

Willenbrock, Klaus, Roers, Axel, Blöhbaum, Birgit, Rajewsky, Klaus, Hansmann, Martin-Leo

A minor component (about 25%) of lymphocytes in Hodgkin’s disease (HD) are CD8+ T cells. It is unclear whether the presence of these cells reflects an antitumor cytotoxic response. The goal of the...

Analysis of T-Cell Subpopulations in T-Cell Non-Hodgkin’s Lymphoma of Angioimmunoblastic Lymphadenopathy with Dysproteinemia Type by Single Target Gene Amplification of T Cell Receptor- β Gene Rearrangements

Willenbrock, Klaus, Roers, Axel, Seidl, Christian, Wacker, Hans-Heinrich, Küppers, Ralf, Hansmann, Martin-Leo

Angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) is defined in the current lymphoma classifications as a T-cell non-Hodgkin’s lymphoma. However, in approximately one third of the cases...

Accelerated Wound Closure in Mice Deficient for Interleukin-10

Eming, Sabine A., Werner, Sabine, Bugnon, Philippe, Wickenhauser, Claudia, Siewe, Lisa, Utermöhlen, Olaf, ...

The impact of the local inflammatory response on the process of wound healing has been debated for decades. In particular, the question whether infiltrating macrophages and granulocytes promote or...

T Cell–specific Inactivation of the Interleukin 10 Gene in Mice Results in Enhanced T Cell Responses but Normal Innate Responses to Lipopolysaccharide or Skin Irritation

Roers, Axel, Siewe, Lisa, Strittmatter, Elke, Deckert, Martina, Schlüter, Dirk, Stenzel, Werner, ...

Interleukin (IL)-10 is a regulator of inflammatory responses and is secreted by a variety of different cell types including T cells. T regulatory cells have been shown to suppress immune responses by...

Mast cell-specific Cre/loxP-mediated recombination in vivo

Scholten, Julia, Hartmann, Karin, Gerbaulet, Alexander, Krieg, Thomas, Müller, Werner, Testa, Giuseppe, ...

Mast cells are important effectors of type I allergy but also essential regulators of innate and adaptive immune responses. The aim of this study was to develop a Cre recombinase-expressing mouse...

Clonal Expansions of Cd8+ T Cells Dominate the T Cell Infiltrate in Active Multiple Sclerosis Lesions as Shown by Micromanipulation and Single Cell Polymerase Chain Reaction

Babbe, Holger, Roers, Axel, Waisman, Ari, Lassmann, Hans, Goebels, Norbert, Hohlfeld, Reinhard, ...

Clonal composition and T cell receptor (TCR) repertoire of CD4+ and CD8+ T cells infiltrating actively demyelinating multiple sclerosis (MS) lesions were determined with unprecedented resolution at...

Rare Occurrence of Classical Hodgkin's Disease as a T Cell Lymphoma

Müschen, Markus, Rajewsky, Klaus, Bräuninger, Andreas, Baur, Audrey Sylvia, Oudejans, Joost J., Roers, Axel, ...

Recent work identified Hodgkin and Reed-Sternberg (H/RS) cells in classical Hodgkin's disease (cHD) as clonal progeny of mature B cells. Therefore, it is generally assumed that cHD homogenously...