Sakaguchi, Ayako, Miyaike, Mitsuko, Kuroda, Kazufumi, Nozaki, Naohito, Tanaka, Masato, Hibino, Makoto, ...
The epitopes of about 100 monoclonal antibodies against human type II DNA topoi-somerase were mapped along the enzyme molecules. Although they were randomly and independently established, epitope...
Sakaguchi, Ayako, Steward, Ruth
PR-Set7 is a histone methyltransferase that specifically monomethylates histone H4 lysine 20 (K20) and is essential for cell proliferation. Our results show that in PR-Set7 mutants, the DNA damage...
Functional Characterization of the Drosophila Hmt4-20/Suv4-20 Histone Methyltransferase
Sakaguchi, Ayako, Karachentsev, Dmitry, Seth-Pasricha, Mansha, Druzhinina, Marina, Steward, Ruth
Di- and trimethylation of histone H4 lysine20 (H4K20) are thought to play an important role in controlling gene expression in vertebrates and in Drosophila. By inducing a null mutation in Drosophila...