Identification of the Transactivating Region of the Homeodomain Protein, Hex (2004)
Kasamatsu, Shinya, Sato, Ayuko, Yamamoto, Taichi, Keng, Vincent W., Yoshida, Hiroshi, Yamazaki, Yuka, ...
The homeodomain-containing protein Hex acts as an activator as well as a repressor of transcription in animals. While its repression domain has been mapped to the amino-terminal region, the...
Sato, Ayuko, Keng, Vincent W., Yamamoto, Taichi, Kasamatsu, Shinya, Ban, Tomoko, Tanaka, Hironori, ...
Hex is one of the homeobox genes suggested to be important for hematopoietic cell differentiation. However, its biological function and mechanism of transcriptional regulation in hematopoietic cells...
Sp Family Members Stimulate Transcription of the Hex Gene via Interactions with GC Boxes (2001)
Kikkawa, Eri, Hinata, Makiyo, Keng, Vincent W, Myint, Zaw, Sato, Ayuko, Yamada, Kazuya, ...
The 5'-flanking region of the mouse Hex gene was examined in order to identify transcription factors regulating its expression in hepatocytes and haematopoietic cells. We have identified two further...
Recognition of single-stranded RNA viruses by Toll-like receptor 7
Lund, Jennifer M., Alexopoulou, Lena, Sato, Ayuko, Karow, Margaret, Adams, Niels C., Gale, Nicholas W., ...
Viral infection of mammalian host results in the activation of innate immune responses. Toll-like receptors (TLRs) have been shown to mediate the recognition of many types of pathogens, including...
Pattern recognition by Toll-like receptors (TLRs) is known to be important for the induction of dendritic cell (DC) maturation. DCs, in turn, are critically important in the initiation of T cell...
Innate control of adaptive immunity via remodeling of lymph node feed arteriole
Soderberg, Kelly A., Payne, Geoffrey W., Sato, Ayuko, Medzhitov, Ruslan, Segal, Steven S., Iwasaki, Akiko
The adaptive immune system relies on rare cognate lymphocytes to detect pathogen-derived antigens. Naïve lymphocytes recirculate through secondary lymphoid organs in search of cognate antigen. Here,...
Recognition of single-stranded RNA viruses by Toll-like receptor 7
Lund, Jennifer M., Alexopoulou, Lena, Sato, Ayuko, Karow, Margaret, Adams, Niels C., Gale, Nicholas W., ...
Viral infection of mammalian host results in the activation of innate immune responses. Toll-like receptors (TLRs) have been shown to mediate the recognition of many types of pathogens, including...
Pattern recognition by Toll-like receptors (TLRs) is known to be important for the induction of dendritic cell (DC) maturation. DCs, in turn, are critically important in the initiation of T cell...
Innate control of adaptive immunity via remodeling of lymph node feed arteriole
Soderberg, Kelly A., Payne, Geoffrey W., Sato, Ayuko, Medzhitov, Ruslan, Segal, Steven S., Iwasaki, Akiko
The adaptive immune system relies on rare cognate lymphocytes to detect pathogen-derived antigens. Naïve lymphocytes recirculate through secondary lymphoid organs in search of cognate antigen. Here,...
Dual recognition of herpes simplex viruses by TLR2 and TLR9 in dendritic cells
Sato, Ayuko, Linehan, Melissa M., Iwasaki, Akiko
Dendritic cells (DCs) express multiple Toll-like receptors (TLR) in distinct cellular locations. Herpes simplex viruses (HSV) have been reported to engage both the surface TLR2 and intracellular TLR9...
Oncostatin M Gene Therapy Attenuates Liver Damage Induced by Dimethylnitrosamine in Rats
Hamada, Tetsuhiro, Sato, Ayuko, Hirano, Tadamichi, Yamamoto, Takashi, Son, Gakuhei, Onodera, Masayuki, ...
To assess the usefulness of oncostatin M (osm) gene therapy in liver regeneration, we examined whether the introduction of OSM cDNA enhances the regeneration of livers damaged by dimethylnitrosamine...
Toll-like Receptor 9–mediated Recognition of Herpes Simplex Virus-2 by Plasmacytoid Dendritic Cells
Lund, Jennifer, Sato, Ayuko, Akira, Shizuo, Medzhitov, Ruslan, Iwasaki, Akiko
Plasmacytoid dendritic cells (pDCs) have been identified as a potent secretor of the type I interferons (IFNs) in response to CpG as well as several viruses. In this study, we examined the molecular...