Human immunodeficiency virus type 1 (HIV-1) is genetically highly variable. This is attributed to the error-prone nature of HIV-1 replication and its proclivity for recombination. During replication...
Cheng, K C, Preston, B D, Cahill, D S, Dosanjh, M K, Singer, B, Loeb, L A
Vinyl chloride is a known human and rodent carcinogen that forms several cyclic base derivatives in DNA. The mutagenic potential of these derivatives has been examined in vitro but not in vivo. One...
Wei, S J, Chang, R L, Wong, C Q, Bhachech, N, Cui, X X, Hennig, E, ...
Mutations in the coding region of the hypoxanthine (guanine) phosphoribosyltransferase (HPRT) gene of Chinese hamster V-79 cells were examined after exposure of the cells to a high cytotoxic dose...
Parthasarathi, S, Varela-EchavarrÃa, A, Ron, Y, Preston, B D, Dougherty, J P
Retroviruses evolve at rapid rates, which is presumably advantageous for responding to selective pressures. Understanding the basic mutational processes involved during retroviral replication is...
Li, X, Quan, Y, Arts, E J, Li, Z, Preston, B D, De Rocquigny, H, ...
Retroviral reverse transcription starts near the 5' end of unspliced viral RNA at a sequence called the primer binding site (PBS), where the tRNA primer anneals to the RNA template for initiation of...
Klarmann, G J, Yu, H, Chen, X, Dougherty, J P, Preston, B D
Human immunodeficiency virus type 1 (HIV-1) replication requires conversion of viral RNA to double-stranded DNA. To better understand the molecular mechanisms of this process, we examined viral DNA...
Perrino, F W, Preston, B D, Sandell, L L, Loeb, L A
The unusually high error rate of human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) suggests that polymerization errors by this enzyme contribute to the genetic variability of the...
Fidelity of two retroviral reverse transcriptases during DNA-dependent DNA synthesis in vitro.
Roberts, J D, Preston, B D, Johnston, L A, Soni, A, Loeb, L A, Kunkel, T A
We determined the fidelity of avian myeloblastosis virus and Moloney murine leukemia virus reverse transcriptases (RTs) during DNA synthesis in vitro using the M13mp2 lacZ alpha gene as a mutational...
Preston, B D, Singer, B, Loeb, L A
O4-Alkylthymine-DNA adducts have been implicated as causative lesions in chemical mutagenesis and carcinogenesis. To directly assess the mutagenic potential of these adducts in vivo, we have designed...
Human immunodeficiency virus type 1 (HIV-1) is genetically highly variable. This is attributed to the error-prone nature of HIV-1 replication and its proclivity for recombination. During replication...
Cheng, K C, Preston, B D, Cahill, D S, Dosanjh, M K, Singer, B, Loeb, L A
Vinyl chloride is a known human and rodent carcinogen that forms several cyclic base derivatives in DNA. The mutagenic potential of these derivatives has been examined in vitro but not in vivo. One...
Wei, S J, Chang, R L, Wong, C Q, Bhachech, N, Cui, X X, Hennig, E, ...
Mutations in the coding region of the hypoxanthine (guanine) phosphoribosyltransferase (HPRT) gene of Chinese hamster V-79 cells were examined after exposure of the cells to a high cytotoxic dose...
Parthasarathi, S, Varela-EchavarrÃa, A, Ron, Y, Preston, B D, Dougherty, J P
Retroviruses evolve at rapid rates, which is presumably advantageous for responding to selective pressures. Understanding the basic mutational processes involved during retroviral replication is...
Li, X, Quan, Y, Arts, E J, Li, Z, Preston, B D, De Rocquigny, H, ...
Retroviral reverse transcription starts near the 5' end of unspliced viral RNA at a sequence called the primer binding site (PBS), where the tRNA primer anneals to the RNA template for initiation of...
Klarmann, G J, Yu, H, Chen, X, Dougherty, J P, Preston, B D
Human immunodeficiency virus type 1 (HIV-1) replication requires conversion of viral RNA to double-stranded DNA. To better understand the molecular mechanisms of this process, we examined viral DNA...
Perrino, F W, Preston, B D, Sandell, L L, Loeb, L A
The unusually high error rate of human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) suggests that polymerization errors by this enzyme contribute to the genetic variability of the...
Fidelity of two retroviral reverse transcriptases during DNA-dependent DNA synthesis in vitro.
Roberts, J D, Preston, B D, Johnston, L A, Soni, A, Loeb, L A, Kunkel, T A
We determined the fidelity of avian myeloblastosis virus and Moloney murine leukemia virus reverse transcriptases (RTs) during DNA synthesis in vitro using the M13mp2 lacZ alpha gene as a mutational...
Preston, B D, Singer, B, Loeb, L A
O4-Alkylthymine-DNA adducts have been implicated as causative lesions in chemical mutagenesis and carcinogenesis. To directly assess the mutagenic potential of these adducts in vivo, we have designed...