A survey of frog odorous secretions, their possible functions and phylogenetic significance (2004)
Smith, B. P.C., Williams, C. R., Tyler, Michael J., Williams, B. D.
Bioremediation of DDT-contaminated soil: Enhancement by seaweed addition (2004)
Kantachote, D., Naidu, R., Williams, B. D., McClure, N. C., Megharaj, M., Singleton, I.
A survey of frog odorous secretions, their possible functions and phylogenetic significance (2004)
Smith, B. P.C., Williams, C. R., Tyler, Michael J., Williams, B. D.
Bioremediation of DDT-contaminated soil: Enhancement by seaweed addition (2004)
Kantachote, D., Naidu, R., Williams, B. D., McClure, N. C., Megharaj, M., Singleton, I.
Williams, A. S., Topley, N., Dojcinov, S., Richards, P. J., Williams, B. D.
Objectives. We examined the temporal changes in the expression of interleukin 1β (IL‐1β), tumour necrosis factor α (TNF‐α) and interleukin 6...
Richards, P. J., Williams, B. D., Williams, A. S.
Objectives. To investigate the role of macrophages in the pathogenesis of chronic streptococcal cell wall (SCW)‐induced arthritis using liposomal clodronate. Methods. Female...
Solid-phase microextraction as a tool for studying volatile compounds in frog skin (2000)
Smith, B. P. C., Alcaraz Zini, C., Pawliszyn, J., Tyler, Michael J., Hayasaka, Y., Williams, B. D., ...
Solid-phase microextraction as a tool for studying volatile compounds in frog skin (2000)
Smith, B. P. C., Alcaraz Zini, C., Pawliszyn, J., Tyler, Michael J., Hayasaka, Y., Williams, B. D., ...
Clinical protocol for monitoring of targeted therapies in rheumatoid arthritis (2000)
Geborek, P., Saxne, T., Emery, P., Panayi, G., Sturrock, R. D., Williams, B. D.
Richards, P. J., Williams, A. S., Goodfellow, R. M., Williams, B. D.
Objectives. To investigate the efficacy of a single i.v. dose of clodronate encapsulated within small unilamellar vesicles in suppressing joint inflammation and the histological progression of rat...
Pro-inflammatory effects of the aminobisphosphonate ibandronate in vitro and in vivo (1999)
Richards, P. J., Amos, N., Williams, A. S., Williams, B. D.
Objectives. To investigate the effects of the aminobisphosphonate, ibandronate, on the course of joint inflammation in rat antigen-induced arthritis (AIA) and the release of pro-inflammatory...
ILIOPSOAS BURSITIS--AN UNUSUAL PRESENTATION OF METASTATIC BONE DISEASE (1996)
BYRNE, P. A. C., REES, J. I. S., WILLIAMS, B. D.
Diagnostic uncertainty concerning the nature of an enlarging inguinal mass in an elderly male with a short history of hip pain was resolved by a combination of ultrasound and magnetic resonance...
WILLIAMS, A. S., CAMILLERI, J. P., GOODFELLOW, R. M., WILLIAMS, B. D.
In this study, we sought to determine whether liposomal preparations containing a phospholipid conjugate of methotrexate and dimyristoylphosphatidylethanolamine (MTX-γ-DMPE) incorporated within...
LLOYDS, D., DAVIES, E. V., WILLIAMS, B. D., HALLETT, M. B.
The priming of neutrophils is associated with an increase in the level of tyrosine phosphorylation of cytosolic proteins, specifically of proteins with mol. wts of 42 and 74 kDa. We show here, using...
CASE REPORT: SILENT MYOCARDIAL INFARCTION IN WEGENER'S GRANULOMATOSIS (1996)
LAWSON, T. M., WILLIAMS, B. D.
Histological cardiac abnormalities in Wegener's granulomatosis can frequently be demonstrated at post-mortem examination, but clinically significant cardiac involvement is rare. We describe a massive...
WILLIAMS, A. S., PUNN, Y. L., AMOS, N., COOPER, A. M., WILLIAMS, B. D.
The ability of methotrexate (MTX) and a liposomal preparation containing a lipophilic conjugate of methotrexate (MTX-LIPO) to modulate pro-inflammatory mediator release from...
MINOCYCLINE-RELATED LUPUS (1994)
BYRNE, P. A. C., WILLIAMS, B. D., PRITCHARD, M. H.
Five cases of suspected drug-related lupus are described in young female patients who had been taking minocycline for several years. All were asymptomatic before starting treatment. After variable...
CHRONIC ARTERIAL OCCLUSION ASSOCIATED WITH BEHCET'S DISEASE (1994)
COOPER, A. M., NAUGHTON, M. N., WILLIAMS, B. D.
We describe two patients with Behçst's disease who developed mild symptoms of chronic upper limb arterial insufficiency. Angiography revealed multiple arterial occlusions. Slowly progressive...
HLA-DRB GENES AND ANTIRIBOSOMAL P ANTIBODIES IN SYSTEMIC LUPUS ERYTHEMATOSUS (1994)
TEH, L. S., DOHERTY, D. G., WILLIAMS, B. D.
Antibodies to the ribosomal P protein are specific for SLE but their prevalence varies in different ethnic groups. In a group of Chinese SLE patients from Malaysia who have a high prevalence of this...
JONES, J., LAFFAFIAN, I., COOPER, A. M., WILLIAMS, B. D., MORGAN, B. P.
In an effort to elucidate the activation status of neutrophils (PMN) in inflammatory joint disease the expression of relevant cell surface proteins was examined using immunofluorescence and flow...
IS THE CONSTRUCTION OF AN ILEOANAL POUCH ASSOCIATED WITH THE DEVELOPMENT OF ARTHRITIS? (1994)
NAUGHTON, M., YOUNG, H., HUGHES, L., WILLIAMS, B. D.
The construction of an ileoanal pouch in patients who have undergone total colectomy for ulcerative colitis is claimed to be associated with the development of arthritis. The pattern and prevalence...
SUPPRESSION OF ADJUVANT-INDUCED ARTHRITIS BY LIPOSOMALLY CONJUGATED METHOTREXATE IN THE RAT (1994)
WILLIAMS, A. S., CAMILLERI, J. P., WILLIAMS, B. D.
A phospholipid conjugate of methotrexate was synthesized and liposomally formulated in order to determine whether such a formulation could modulate the severity of experimentally induced arthritis in...
IDIOPATHIC RECURRENT NON-SUPPURATIVE FOCAL MYOSITIS: A REPORT OF TWO CASES (1993)
NAUGHTON, M., JESSOP, J. D., WILLIAMS, B. D.
We describe two patients with acute recurrent focal myositis affecting discrete muscle groups. Sepsis was initially suspected in both cases and excluded only after surgical intervention. Spontaneous...
TEH, L. S., LEE, M. K., WANG, F., MANIVASAGAR, M., CHARLES, P. J., NICHOLSON, G. D., ...
We report a significantly increased prevalence of antiribosomal P protein antibodies in Malaysian Chinese patients (38%) with SLE compared to white Caucasian (13%) and Afro-Caribbean...
RECURRENT POLYARTHRITIS IN A YOUNG WOMAN WITH AN ILEOANAL POUCH FOR ULCERATIVE COLITIS (1993)
We describe a patient who, following the construction of an ileoanal pouch developed a seronegative polyarthritis.
COOPER, A. M., HAYWARD, C., WILLIAMS, B. D.
Two cases presenting with pseudocyst formation due to pyrophosphate arthropathy involving the acromioclavicular joint are described.
TEH, L. S., HAY, E. M., AMOS, N., BLACK, D., HUDDY, A., CREED, F., ...
In a cross-sectional study, 62 patients with systemic lupus erythematosus were assessed using standardized psychiatric and psychological methods; systemic disease activity was scored using the...
DAVIES, E. V., CAMPBELL, A. K., WILLIAMS, B. D., HALLETT, M. B.
Intracellular calcium (Ca2+) signalling in synovial fluid (SF) polymorphonuclear leucocytes(PMN) from patients with rheumatoid arthritis (RA) was compared to RA and normal circulating blood PMN...
RICHARDS, I. M., WHITE, A. M., O'SULLIVAN, M. M., JESSOP, J. D., WILLIAMS, B. D.
A 26-year-old female developed a unilateral hypoglossal nerve palsy in association with tuberculosis of the first cervical vertebra. The extensive soft tissue and bony abnormalities were demonstrated...
TUMOUR NECROSIS FACTOR ACTIVITY IN JOINT FLUIDS FROM RHEUMATOID ARTHRITIS PATIENTS (1989)
NEALE, M. L., WILLIAMS, B. D., MATTHEWS, N.
Although tumour necrosis factor (TNF) was first studied as an anti-cancer agent it is now recognized as a potent mediator of inflammation and could potentially play a role in rheumatoid arthritis. In...
CAROTID SINUS HYPERSENSITIVITY AND COMPLETE HEART BLOCK IN REITER'S SYNDROME (1988)
SHETTY, H. G. M., FRASER, A. G., PHILLIPS, D. I. W., LAZARUS, J. H., WILLIAMS, B. D.
We describe a 42-year-old man with Reiter's syndrome who developed complete heart block only 5 wee after the onset of his illness. He was also noted to have carotid sinus hypersensitivity and...
SMITH, J. A. E., O'SULLIVAN, M., GOUGH, J., WILLIAMS, B. D.
This report describes small-bowel perforation caused by giant-cell arteritis of the regional mesenteric vessels. No evidence of giant-cell arteritis at other sites was discovered and 18 months after...
Rescue of a paralyzed-flagella mutant of Chlamydomonas by transformation.
Diener, D R, Curry, A M, Johnson, K A, Williams, B D, Lefebvre, P A, Kindle, K L, ...
The biflagellate alga Chlamydomonas has been used extensively in the genetic and biochemical analysis of flagellar assembly and motility. We have restored motility to a paralyzed-flagella mutant of...
Sequence analysis reveals homology between two proteins of the flagellar radial spoke.
Curry, A M, Williams, B D, Rosenbaum, J L
Flagellar radial spokes contribute to the regulation of dynein arm activity and thus the pattern of flagellar bending. We have sequenced the genes for radial spoke protein 4 (RSP4) and RSP6, two of...
Polymyalgia rheumatica: pitfalls in diagnosis
Siebert, S, Lawson, T M, Wheeler, M H, Martin, J C, Williams, B D
Imaging in rheumatoid arthritis using liposomes labelled with technetium.
Williams, B D, O'Sullivan, M M, Saggu, G S, Williams, K E, Williams, L A, Morgan, J R
Tai, P C, Holt, M E, Denny, P, Gibbs, A R, Williams, B D, Spry, C J
Biopsy specimens and tissues obtained at necropsy from two women who died after developing the Churg-Strauss syndrome were analysed to see whether granulomas in these patients contained activated...
A Genetic Mapping System in Caenorhabditis Elegans Based on Polymorphic Sequence-Tagged Sites
Williams, B. D., Schrank, B., Huynh, C., Shownkeen, R., Waterston, R. H.
We devised an efficient genetic mapping system in the nematode Caenorhabditis elegans which is based upon the differences in number and location of the transposable element Tc1 between the Bristol...
Inhibition of reticuloendothelial function by gold and its relation to postinjection reactions.
Williams, B D, Lockwood, C M, Pussell, B A
A patient with rheumatoid arthritis developed severe exacerbation of symptoms 18 hours after an injection of gold thiomalate (sodium aurothiomalate). Immune complexes were present in his serum and...
Immune complexes in Behçet's syndrome and recurrent oral ulceration.
Seventeen patients with Behçet's syndrome, 11 with recurrent oral ulceration, and eight controls were studied in an investigation of the part possibly played by immune complexes in the transition...
Urinary Excretion of C3 Antigen in Glomerulonephritis
Williams, B. D., Clarkson, A. R., Row, P. G., Groves, R. J., Cameron, J. S.
C3 and fibrin degradation products (F.D.P.) have been measured in early morning urine samples from 38 normal people and 123 patients with glomerulonephritis. Normal urine contained less than 0·3 μg...
Circulating immune complexes after repeated halothane anaesthesia.
Williams, B D, White, N, Amlot, P L, Slaney, J, Toseland, P A
A patient developed hepatitis after receiving three halothane anaesthetics in 22 days. Twenty-four hours after the onset of jaundice she developed an acute serum sickness syndrome with...
Rescue of a paralyzed-flagella mutant of Chlamydomonas by transformation.
Diener, D R, Curry, A M, Johnson, K A, Williams, B D, Lefebvre, P A, Kindle, K L, ...
The biflagellate alga Chlamydomonas has been used extensively in the genetic and biochemical analysis of flagellar assembly and motility. We have restored motility to a paralyzed-flagella mutant of...
Sequence analysis reveals homology between two proteins of the flagellar radial spoke.
Curry, A M, Williams, B D, Rosenbaum, J L
Flagellar radial spokes contribute to the regulation of dynein arm activity and thus the pattern of flagellar bending. We have sequenced the genes for radial spoke protein 4 (RSP4) and RSP6, two of...
A Genetic Mapping System in Caenorhabditis Elegans Based on Polymorphic Sequence-Tagged Sites
Williams, B. D., Schrank, B., Huynh, C., Shownkeen, R., Waterston, R. H.
We devised an efficient genetic mapping system in the nematode Caenorhabditis elegans which is based upon the differences in number and location of the transposable element Tc1 between the Bristol...
Polymyalgia rheumatica: pitfalls in diagnosis
Siebert, S, Lawson, T M, Wheeler, M H, Martin, J C, Williams, B D
Imaging in rheumatoid arthritis using liposomes labelled with technetium.
Williams, B D, O'Sullivan, M M, Saggu, G S, Williams, K E, Williams, L A, Morgan, J R
Tai, P C, Holt, M E, Denny, P, Gibbs, A R, Williams, B D, Spry, C J
Biopsy specimens and tissues obtained at necropsy from two women who died after developing the Churg-Strauss syndrome were analysed to see whether granulomas in these patients contained activated...
Inhibition of reticuloendothelial function by gold and its relation to postinjection reactions.
Williams, B D, Lockwood, C M, Pussell, B A
A patient with rheumatoid arthritis developed severe exacerbation of symptoms 18 hours after an injection of gold thiomalate (sodium aurothiomalate). Immune complexes were present in his serum and...
Immune complexes in Behçet's syndrome and recurrent oral ulceration.
Seventeen patients with Behçet's syndrome, 11 with recurrent oral ulceration, and eight controls were studied in an investigation of the part possibly played by immune complexes in the transition...
Urinary Excretion of C3 Antigen in Glomerulonephritis
Williams, B. D., Clarkson, A. R., Row, P. G., Groves, R. J., Cameron, J. S.
C3 and fibrin degradation products (F.D.P.) have been measured in early morning urine samples from 38 normal people and 123 patients with glomerulonephritis. Normal urine contained less than 0·3 μg...
Circulating immune complexes after repeated halothane anaesthesia.
Williams, B D, White, N, Amlot, P L, Slaney, J, Toseland, P A
A patient developed hepatitis after receiving three halothane anaesthetics in 22 days. Twenty-four hours after the onset of jaundice she developed an acute serum sickness syndrome with...
Daniels, R H, Williams, B D, Morgan, B P
The effects of non-lethal amounts of a variety of pore-forming agents on cultured human rheumatoid synovial cells (HRSC) have been investigated. Non-lethal complement membrane attack and non-lethal...
Yousaf, N, Howard, J C, Williams, B D
The function of the hepatic component of the mononuclear phagocyte system (MPS) was investigated in the rat using N-ethylmaleimide (NEM)-treated erythrocytes and erythrocytes sensitized with a rat...
Stimulation of human rheumatoid synovial cells by non-lethal complement membrane attack.
Daniels, R H, Houston, W A, Petersen, M M, Williams, J D, Williams, B D, Morgan, B P
The effects of non-lethal complement attack on cultured human rheumatoid synovial cells have been investigated by measuring a variety of parameters. Within 3-4 min of initiating non-lethal complement...
Yousaf, N, Howard, J C, Williams, B D
The effects of immune complex infusion on the clearance of antibody (R3/13)-coated and NEM-treated rat erythrocytes by the splenic component of the rat mononuclear phagocyte system (MPS) were...
Yousaf, N, Howard, J C, Williams, B D
The splenic component of the mononuclear phagocyte system (MPS) was investigated in the rat using N-ethylmaleimide-treated erythrocytes (NEM) and erythrocytes coated with a monoclonal IgG2b antibody...
Circulating immune complexes in patients with ankylosing spondylitis.
Panayi, G S, Slaney, J, Williams, B D
EDTA plasma samples from 13 patients with ankylosing spondylitis (AS) were fractionated on Sephadex G-200 and the quantities of C3 and IgG within the first protein peak determined by a sensitive...
Detection of immune complexes in serum of patients with ankylosing spondylitis.
Corrigall, V, Panayi, G S, Unger, A, Poston, R N, Williams, B D
Immune complexes were measured in the sera of 18 patients iwth ankylosing spondylitis and 5 normal control subjects by their ability to inhibit antibody-mediated lymphocyte-induced cytotoxicity. 11...
O'Sullivan, M M, Rumfeld, W R, Jones, M K, Williams, B D
A case of Cushing's syndrome after long term intra-articular corticosteroid injections is described. Prolonged suppression of the hypothalamic-pituitary-adrenal axis occurred as assessed by an...
Synovial accumulation of technetium labelled liposomes in rheumatoid arthritis.
Williams, B D, O'Sullivan, M M, Saggu, G S, Williams, K E, Williams, L A, Morgan, J R
Technetium labelled, negatively charged, unilamellar liposomes were given by intravenous injection to patients with rheumatoid arthritis and the joints scanned 20-22 hours later. Positive...
Inflammatory joint disease: a comparison of liposome scanning, bone scanning, and radiography.
O'Sullivan, M M, Powell, N, French, A P, Williams, K E, Morgan, J R, Williams, B D
Patients with rheumatoid arthritis, psoriatic arthritis, and osteoarthritis were assessed by clinical evaluation, radiography, and joint scintigraphy using technetium labelled methylene diphosphonate...
Love, W G, Amos, N, Kellaway, I W, Williams, B D
Technetium-99m labelled, negatively charged liposomes accumulate in the inflamed tissue of rats with adjuvant induced arthritis. Up to 10 times more liposome accumulation was seen in inflamed paws...
Behçet's syndrome: severe proctitis with rectovaginal fistula formation.
Teh, L S, Green, K A, O'Sullivan, M M, Morris, J S, Williams, B D
The development of severe proctitis and a rectovaginal fistula two months after the onset of Behçet's syndrome in a 41 year old woman is reported.
Systemic lupus erythematosus presenting as pneumococcal septicaemia and septic arthritis.
Webster, J, Williams, B D, Smith, A P, Hall, M, Jessop, J D
A 50 year old woman presented with pneumococcal septicaemia, septic arthritis, and a lobar pneumonia and was subsequently diagnosed as having systemic lupus erythematosus. The blood film and splenic...
Recurrent papilloedema and early onset optic atrophy in Behçet's syndrome.
Teh, L S, O'Connor, G M, O'Sullivan, M M, Pandit, J C, Beck, L, Williams, B D
Two patients with Behçet's syndrome and intracranial hypertension are reported. One developed a recurrence of papilloedema while receiving treatment but eventually made a full recovery, whereas the...
Love, W G, Amos, N, Kellaway, I W, Williams, B D
High performance liquid chromatography has shown that after intravenous injection cholesterol-poor liposomes (100 nm) are unstable and their phospholipid is redistributed. Under identical conditions...
Selective IgA deficiency associated with glomerulonephritis and oligoarthritis.
Camilleri, J P, Moore, R H, Griffiths, D F, Williams, B D
A 59 year old woman with selective IgA deficiency associated with oligoarthritis and glomerulonephritis is described. She was seropositive for rheumatoid factor and renal histological examination...
Antibodies to protein P in systemic lupus erythematosus.
Teh, L S, Bedwell, A E, Isenberg, D A, Gordon, C, Emery, P, Charles, P J, ...
A synthetic peptide was used to develop an enzyme linked immunosorbent assay (ELISA) to detect antibodies to the ribosomal proteins P0, P1, and P2. Significantly increased levels of IgG antibodies to...
Altered Ca2+ signalling in human neutrophils from inflammatory sites.
Davies, E V, Williams, B D, Whiston, R J, Cooper, A M, Campbell, A K, Hallett, M B
OBJECTIVES--To determine whether the intracellular store release of Ca2+ in neutrophils from patients with rheumatoid arthritis, other joint disease and active leg ulceration was different from...
O'Sullivan, M M, Amos, N, Williams, B D
Serum samples from patients with seropositive rheumatoid arthritis contain an inhibitor of complement mediated inhibition of immune precipitation (CMIP). This inhibitory effect can be produced by the...
Jones, J, Laffafian, I, Lawson, T, Williams, B D, Morgan, B P
OBJECTIVE: To compare neutrophil Fc receptor (Fc gamma R) and CD59 signalling responses in normal healthy subjects and patients with active rheumatoid arthritis (RA). METHODS: Intracellular free...
Camilleri, J P, Williams, A S, Amos, N, Douglas-Jones, A G, Love, W G, Williams, B D
Clodronate, encapsulated within small unilamellar vesicles (SUVc) will deplete hepatic macrophages after intravenous injection. Functional studies, using probes to evaluate hepatic Fc and C3b uptake,...
Demonstration of hepatic Fc receptor function in vivo.
Yousaf, N, Howard, J C, Williams, B D
We describe an investigation of the Fc-receptor dependent function of the hepatic component of the mononuclear phagocyte system (MPS) in rats. Erythrocytes sensitized with the rat IgG2b monoclonal...
Oleesky, D A, Daniels, R H, Williams, B D, Amos, N, Morgan, B P
Terminal complement complex (TCC) and C1r-C1s-C1 inhibitor complex (C1/C1 INH) concentrations were measured in plasma and synovial fluid from patients with arthritis and related to other measures of...
Immune complexes in Hodgkin's disease: isolation, immunochemical and physico-chemical analysis.
Kilgallon, W, Amlot, P L, Williams, B D
Immune complexes (IC) present in sera from patients with Hodgkin's disease (HD) were isolated using three different affinity columns: C1q-degalan, anti-C1q sepharose and conglutinin (K)-degalan. The...
Kilgallon, W, Amlot, P L, Williams, B D
An efficient and reproducible procedure has been developed for the specific isolation of immune complexes. PEG precipitation of EDTA serum or plasma was an essential preliminary step to separate...
Immunoconglutinins and C3 in human saliva.
Williams, B D, Challacombe, S J, Slaney, J M, Lachmann, P J, Lehner, T
High titres of immunoconglutinin activity (antibody to bound complement components) have been found in the parotid, sublingual and submandibular saliva of most healthy subjects. The immunoconglutinin...
Correlation between immune complexes and prognostic factors in Hodgkin's disease
Amlot, P. L., Pussell, B., Slaney, J. M., Williams, B. D.
Serum or plasma samples from sixty-two patients with Hodgkin's disease (HD) were tested by four assays for circulating immune complexes or complement activation products: macromolecular C3 (MMC3),...
Comparative clinical study of protein SAP (amyloid P component) and C-reactive protein in serum.
Pepys, M B, Dash, A C, Markham, R E, Thomas, H C, Williams, B D, Petrie, A
The serum concentration of protein SAP (amyloid P component) has been measured for the first time in a substantial series of normal individuals and patients with various diseases, and the results...
Cameron, J S, Lessof, M H, Ogg, C S, Williams, B D, Williams, D G
Serum C4 and C3 concentration and binding of double-stranded-DNA (ds-DNA) were measured in sera from ninety-nine patients with systemic lupus erythematosus and clinical evidence of nephritis. C3 and...
Measurement of terminal complement complexes in rheumatoid arthritis.
Morgan, B P, Daniels, R H, Williams, B D
Though complement activation is recognized as a central event in inflammation in the rheumatoid joint, little attention has been paid to the role of the cytolytic membrane attack complex of...
In vivo and in vitro evidence of cell recovery from complement attack in rheumatoid synovium.
Morgan, B P, Daniels, R H, Watts, M J, Williams, B D
In the previous article we have demonstrated, by quantifying terminal complement complexes in synovial fluid, that membrane attack complex activation occurs in the joint in rheumatoid arthritis. Here...
Yousaf, N, Howard, J C, Williams, B D
The splenic component of the mononuclear phagocyte system (MPS) was investigated in decomplemented rats by determining the clearance from the blood of erythrocytes coated with a monoclonal antibody...
Williams, A S, Camilleri, J P, Amos, N, Williams, B D
In this study we evaluated the comparative efficacy of free and liposomally conjugated methotrexate on both disease induction and suppression of acute inflammation in rat adjuvant-induced arthritis....
Reticuloendothelial Fc function in normal individuals and its relationship to the HLA antigen DR3.
Williams, B D, O'Sullivan, M M, Ratanachaiyavong, S
Reticuloendothelial Fc function was examined in 24 normal individuals by determining the clearance rates of erythrocytes coated with rhesus antibody (IgG RBC) or chemically modified by treatment with...
Reticuloendothelial Fc receptor function in patients with Sjogren's syndrome.
O'Sullivan, M M, Walker, D M, Williams, B D
The functional status of the reticuloendothelial Fc receptor in patients with Sjogren's Syndrome was examined by determining the clearance from the circulation of IgG coated erythrocytes which had...
GOODFELLOW, R M, WILLIAMS, A S, LEVIN, J L, WILLIAMS, B D, MORGAN, B P
Complement activation has been implicated in the pathogenesis of human rheumatoid arthritis. We sought to determine whether inhibition of complement (C) using sCR1 could influence the development and...
Goodfellow, R M, Williams, A S, Levin, J L, Williams, B D, Morgan, B P
We set out to determine whether inhibition of complement using sCR1 could influence the development and progression of collagen arthritis in the Lewis rat. Collagen arthritis was successfully...
Williams, A S, Jones, S G, Goodfellow, R M, Amos, N, Williams, B D
Liposomes with conventional and long-circulation times were employed as carriers for the methotrexate derivative MTX-γ-DMPE (MTX-EPC and MTX-PEG respectively), their mechanism of action was...