Helicobacter pylori requires an acidic environment to survive in the presence of urea.
Clyne, M, Labigne, A, Drumm, B
The aim of this work was to study the significance of the urease enzyme in promoting Helicobacter pylori survival in various environments. A urease-positive H. pylori isolate, strain N6, and an...
The urease enzyme of Helicobacter pylori does not function as an adhesin.
Helicobacter pylori urease is essential for colonization of the gastric mucosa irrespective of whether the stomach is acidic or hypochlorhydric. It has therefore been speculated that the enzyme...
Drumm, B, Roberton, A M, Sherman, P M
Intestinal mucus is postulated to play a role in preventing colonization of the gastrointestinal tract by microbial pathogens. To evaluate the ability of both crude mucus and purified mucin, a...
Long-term storage of Campylobacter pylori.
A reproducible method for long-term storage of Campylobacter pylori has been previously described. We cultured 10 strains of C. pylori in brucella broth that was supplemented with 10% fetal bovine...
Simor, A E, Shames, B, Drumm, B, Sherman, P, Low, D E, Penner, J L
Campylobacter pylori isolates from 37 symptomatic patients and 3 asymptomatic volunteers were examined by chromosomal DNA restriction endonuclease analysis and determination of plasmid profile....
Adherence of Helicobacter pylori to primary human gastrointestinal cells.
Helicobacter pylori adheres only to gastric cells in vivo. However, the organism adheres to a wide variety of nongastric cells in vitro. In this study, we have used flow cytometry to assess the...
Drumm, B, Neumann, A W, Policova, Z, Sherman, P M
The role of hydrophobicity in the attachment of enteropathogens to gastrointestinal mucosa is controversial. In vitro binding of Escherichia coli RDEC-1 to rabbit intestine is dependent on the...
In vitro surface properties of the newly recognized gastric pathogen Helicobacter pylori.
Smith, J I, Drumm, B, Neumann, A W, Policova, Z, Sherman, P M
There appears to be a particular association between Helicobacter pylori and the gastric antrum, but the mechanisms by which the organism adheres to and colonizes the gastric mucosa are unclear....
Helicobacter pylori requires an acidic environment to survive in the presence of urea.
Clyne, M, Labigne, A, Drumm, B
The aim of this work was to study the significance of the urease enzyme in promoting Helicobacter pylori survival in various environments. A urease-positive H. pylori isolate, strain N6, and an...
The urease enzyme of Helicobacter pylori does not function as an adhesin.
Helicobacter pylori urease is essential for colonization of the gastric mucosa irrespective of whether the stomach is acidic or hypochlorhydric. It has therefore been speculated that the enzyme...
Drumm, B, Roberton, A M, Sherman, P M
Intestinal mucus is postulated to play a role in preventing colonization of the gastrointestinal tract by microbial pathogens. To evaluate the ability of both crude mucus and purified mucin, a...
Long-term storage of Campylobacter pylori.
A reproducible method for long-term storage of Campylobacter pylori has been previously described. We cultured 10 strains of C. pylori in brucella broth that was supplemented with 10% fetal bovine...
Simor, A E, Shames, B, Drumm, B, Sherman, P, Low, D E, Penner, J L
Campylobacter pylori isolates from 37 symptomatic patients and 3 asymptomatic volunteers were examined by chromosomal DNA restriction endonuclease analysis and determination of plasmid profile....
Adherence of Helicobacter pylori to primary human gastrointestinal cells.
Helicobacter pylori adheres only to gastric cells in vivo. However, the organism adheres to a wide variety of nongastric cells in vitro. In this study, we have used flow cytometry to assess the...
Drumm, B, Neumann, A W, Policova, Z, Sherman, P M
The role of hydrophobicity in the attachment of enteropathogens to gastrointestinal mucosa is controversial. In vitro binding of Escherichia coli RDEC-1 to rabbit intestine is dependent on the...
In vitro surface properties of the newly recognized gastric pathogen Helicobacter pylori.
Smith, J I, Drumm, B, Neumann, A W, Policova, Z, Sherman, P M
There appears to be a particular association between Helicobacter pylori and the gastric antrum, but the mechanisms by which the organism adheres to and colonizes the gastric mucosa are unclear....
Clyne, M, Thomas, J, Weaver, L, Drumm, B
BACKGROUND: Once Helicobacter pylori infection is established, it is difficult to eradicate despite a persistent systemic and local immune response. It is not known whether immunisation can be used...
Gastric metaplasia and duodenal ulcer disease in children infected by Helicobacter pylori.
Gormally, S M, Kierce, B M, Daly, L E, Bourke, B, Carroll, R, Durnin, M T, ...
BACKGROUND--Helicobacter pylori infection of the gastric mucosa is vital in the pathogenesis of duodenal ulcer disease. H pylori will only colonise gastric epithelium and its association with...
A new polymorphism for the RI22H mutation in hereditary pancreatitis
Howes, N, Greenhalf, W, Rutherford, S, O'Donnell, M, Mountford, R, Ellis, I, ...
BACKGROUND AND AIMS—Hereditary pancreatitis (HP) is a rare form of recurrent acute and chronic pancreatitis. Mutations in the cationic trypsinogen (protease serine 1, PRSS1) gene have been...
Preparing the bowel for colonoscopy.
Abubakar, K, Goggin, N, Gormally, S, Durnin, M, Drumm, B
Bowel preparation methods for total colonoscopy in children generally involve whole gut irrigation with electrolyte lavage solutions, which in most children will require hospitalisation for...
Byler-like familial cholestasis in an extended kindred.
Bourke, B, Goggin, N, Walsh, D, Kennedy, S, Setchell, K D, Drumm, B
Progressive familial intrahepatic cholestasis (PFIC) occurs in many communities and races. A form of PFIC in five children from two consanguineous marriages in an Irish kindred is described. In...
One week treatment for Helicobacter pylori infection
Walsh, D, Goggin, N, Rowland, M, Durnin, M, Moriarty, S, Drumm, B
Accepted 8 November 1996
Effect of Helicobacter pylori eradication on the natural history of duodenal ulcer disease
Goggin, N, Rowland, M, Imrie, C, Walsh, D, Clyne, M, Drumm, B
BACKGROUND—Duodenal ulcer disease is strongly associated with Helicobacter pylori infection of the gastric mucosa. Eradication of H pylori from the gastric mucosa in adults is associated with long...