Bioassays for itraconazole blood levels: an interlaboratory collaborative study (1999)
Odds, F. C., Dupont, B., Rinaldi, M. G., Stevens, D. A., Warnock, D. W., Woestenborghs, R.
Duplicate bioassays for itraconazole and hydroxy-itraconazole were run with 30 serum samples in five laboratories, each using a different method. Both itraconazole and hydroxy- itraconazole were used...
Cardiac lymphoma presenting as atrial flutter in an AIDS patient (1994)
POUSSET, F., LE HEUZEY, J.Y., PIALOUX, G., RINALDI, J. P., HERNIGOU, A., MOUSSEAUX, E., ...
An increasing number of patients with the acquired immunodeficiency syndrome (AIDS) and cardiac lymphoma have been documented. Antemortem diagnosis of cardiac non-Hodgkin lymphoma in AIDS is...
Roithmann, S., Toledano, M., Tourani, J. M., Raphael, M., Gentilini, M., Gastaut, J. A., ...
From 1/87 to 12/89, the French Registry of HIV-associated tumors recorded 131 cases of intermediate- and high-grade non-Hodgkin's lymphomas (NHL). There were 47 small non-cleaved Burkitt-type...
Longuemard, J., Chaari, J., Dupont, B., Tarrats-Saugnac, A.
La réponse acoustique de différents matériaux à des impulsions laser (CO2, YAg et excimère) a été étudiée à l'aide d'une sonde optique (donc sans contact). Les résultats permettent dans...
Longuemard, J., Chaari, J., Dupont, B., Tarrats-Saugnac, A.
La réponse acoustique de différents matériaux à des impulsions laser (CO2, YAg et excimère) a été étudiée à l'aide d'une sonde optique (donc sans contact). Les résultats permettent dans...
Longuemard, J., Chaari, J., Dupont, B., Tarrats-Saugnac, A.
La réponse acoustique de différents matériaux à des impulsions laser (CO2, YAg et excimère) a été étudiée à l'aide d'une sonde optique (donc sans contact). Les résultats permettent dans...
August, A, Gibson, S, Kawakami, Y, Kawakami, T, Mills, G B, Dupont, B
T lymphocytes require two signals to be activated. The antigen-specific T-cell receptor can deliver the first signal, while ligation of the T-cell surface molecule CD28 by antibodies or its cognate...
Hämmerling, G J, Chamberlain, J W, Dill, O, Yang, S Y, Dupont, B, Khan, R, ...
HLA class I-transgenic mice express HLA antigen on their tissues and establish self-tolerance to the expressed monomorphic and polymorphic determinants. When challenged with skin grafts and lymphoid...
Garcia-Hermoso, D, Dromer, F, Improvisi, L, Provost, F, Dupont, B
Fluconazole (FCZ) has been extensively used as a primary therapy for oropharyngeal candidosis in AIDS patients. Clinical resistance to FCZ is now encountered, often related to decreased...
Antifungal prophylaxis during neutropenia and immunodeficiency.
Fungal infections represent a major source of morbidity and mortality in patients with almost all types of immunodeficiencies. These infections may be nosocomial (aspergillosis) or community acquired...
Entry of ketoconazole into Candida albicans.
Boiron, P, Drouhet, E, Dupont, B, Improvisi, L
To define characteristics that determine the entry of ketoconazole (KTZ) into Candida albicans cells, we studied the uptake of [3H]KTZ. The cells rapidly and markedly concentrated the drug: 30% of...
Standardized susceptibility testing of fluconazole: an international collaborative study.
Pfaller, M A, Dupont, B, Kobayashi, G S, Müller, J, Rinaldi, M G, Espinel-Ingroff, A, ...
An international collaborative study of broth dilution (MIC) and disk diffusion susceptibility testing of fluconazole was conducted by using a chemically defined medium (High-Resolution Antifungal...
DNA typing suggests pigeon droppings as a source of pathogenic Cryptococcus neoformans serotype D.
Garcia-Hermoso, D, Mathoulin-Pélissier, S, Couprie, B, Ronin, O, Dupont, B, Dromer, F
The unusual proportion of serotype D strains of Cryptococcus neoformans infecting patients diagnosed with cryptococcosis in some parts of France prompted the analysis of DNA fingerprints obtained...
Dromer, F, Gueho, E, Ronin, O, Dupont, B
The importance of epidemiological studies of cryptococcosis has increased since the beginning of the AIDS epidemic. Cryptococcus neoformans exists in two varieties defining four serotypes,...
Molecular typing of Cryptococcus neoformans serotype D clinical isolates.
Dromer, F, Varma, A, Ronin, O, Mathoulin, S, Dupont, B
Cryptococcus neoformans serotype A is responsible for the majority of cryptococcal infections in AIDS patients. In France, approximately 17% of the patients are infected with serotype D, regardless...
Candida albicans genotyping in studies with patients with AIDS developing resistance to fluconazole.
Bart-Delabesse, E, Boiron, P, Carlotti, A, Dupont, B
We characterized Candida albicans strains responsible for recurrent oropharyngeal candidosis (OPC) in four patients with AIDS who developed clinical and mycological resistance to fluconazole (FCZ)....
Characterization of frequent deletions causing steroid 21-hydroxylase deficiency.
White, P C, Vitek, A, Dupont, B, New, M I
Steroid 21-hydroxylase deficiency is caused by mutations in the CYP21B gene. This gene and a highly homologous pseudogene, CYP21A, alternate with the C4A and C4B genes encoding the fourth component...
Molecular cloning of an inducible serine esterase gene from human cytotoxic lymphocytes.
Trapani, J A, Klein, J L, White, P C, Dupont, B
A cDNA clone encoding a human serine esterase gene was isolated from a library constructed from poly(A)+ RNA of allogeneically stimulated, interleukin 2-expanded peripheral blood mononuclear cells....
Structure of human steroid 21-hydroxylase genes.
White, P C, New, M I, Dupont, B
We have determined the structure of cDNA and two genomic genes encoding steroid 21-hydroxylase [21-OHase; steroid 21-monooxygenase; steroid, hydrogen-donor:oxygen oxidoreductase (21-hydroxylating);...
Two HLA-linked loci controlling the fourth component of human complement.
O'Neill, G J, Yang, S Y, Dupont, B
An electrophoretic polymorphism of the fourth component of human complement (C4) is described. Three patterns of bands of C4 were observed in EDTA plasma from a panel of unrelated blood donors and...
White, P C, New, M I, Dupont, B
We isolated a cDNA clone encoding a bovine adrenal cytochrome P-450 specific for steroid 21-hydroxylation (P-450C21). Serum from rabbits immunized with purified P-450C21 precipitated a single protein...
Evidence for tryosine peptide homologies in the HLA antigens system.
Cunningham-Rundles, C, Jersild, C, Svejgaard, A, Dupont, B, Good, R A
The tetrameric HLA antigens are composed of two heavier chains which carry the alloantigenic determinants and two lighter chains identified as beta2-microglobulin. Although at least 40 different...
Rosenkrantz, K, Dupont, B, Flomenberg, N
Using limiting dilution analysis, we have detected both the generation and suppression of autocytotoxic cells following autologous or allogeneic stimulation in vitro. Assay conditions were...
White, P C, New, M I, Dupont, B
We have determined the molecular genetic basis of congenital adrenal hyperplasia due to 21-hydroxylase (21-OHase) deficiency. This common disorder of cortisol biosynthesis is HLA-linked. The...
White, P C, Grossberger, D, Onufer, B J, Chaplin, D D, New, M I, Dupont, B, ...
Two genes encoding steroid 21-hydroxylase [21-OHase; steroid 21-monooxygenase; steroid, hydrogen-donor: oxygen oxidoreductase (21-hydroxylating); EC 1.14.99.10], a cytochrome P-450 enzyme, have been...
Broxmeyer, H E, Juliano, L, Lu, L, Platzer, E, Dupont, B
Acidic isoferritins, which under normal conditions are released from monocytes and macrophages, have a suppressive effect in vitro on granulocyte-macrophage, erythroid, and multipotential...
Górski, A J, Dupont, B, Hansen, J A, Good, R A
A standardized microculture system has been developed to assess the ability of lymphocytes to secrete leukocyte migration inhibitory factor (LMIF) in response to the nonspecific mitogen...
Chouaib, S, Robb, R J, Welte, K, Dupont, B
We have investigated the inhibitory potential of prostaglandin E2 (PGE2) with respect to intracellular messengers implicated in the signaling system of T-lymphocyte activation pathway. Using the...
Young, J W, Koulova, L, Soergel, S A, Clark, E A, Steinman, R M, Dupont, B
T cells respond to peptide antigen in association with MHC products on antigen-presenting cells (APCs). A number of accessory or costimulatory molecules have been identified that also contribute to T...
Mixed lymphocyte culture determinants, measles infection and multiple sclerosis.
Platz, P, Dupont, B, Fog, T, Ryder, L, Thomsen, M, Svejgaard, A, ...
Frequent deletion and duplication of the steroid 21-hydroxylase genes.
Werkmeister, J W, New, M I, Dupont, B, White, P C
Congenital adrenal hyperplasia due to 21-hydroxylase (21-OHase) deficiency is an HLA-linked disorder resulting from a mutation in the 21-OHase B gene encoding the adrenal cytochrome P450 specific for...
High frequency of nonclassical steroid 21-hydroxylase deficiency.
Speiser, P W, Dupont, B, Rubinstein, P, Piazza, A, Kastelan, A, New, M I
Nonclassical steroid 21-hydroxylase deficiency is an autosomal recessive disorder that is defined by clinical and hormonal criteria that distinguishes it from the classical 21-hydroxylase deficiency....
Pollack, M S, Levine, L S, O'Neill, G J, Pang, S, Lorenzen, F, Kohn, B, ...
Classical congenital adrenal hyperplasia due to 21-hydroxylase deficiency (21-OH-def) has been established to be an HLA-linked, recessive monogenetic disease. However, two nonclassical forms of...
August, A, Gibson, S, Kawakami, Y, Kawakami, T, Mills, G B, Dupont, B
T lymphocytes require two signals to be activated. The antigen-specific T-cell receptor can deliver the first signal, while ligation of the T-cell surface molecule CD28 by antibodies or its cognate...
Hämmerling, G J, Chamberlain, J W, Dill, O, Yang, S Y, Dupont, B, Khan, R, ...
HLA class I-transgenic mice express HLA antigen on their tissues and establish self-tolerance to the expressed monomorphic and polymorphic determinants. When challenged with skin grafts and lymphoid...
Garcia-Hermoso, D, Dromer, F, Improvisi, L, Provost, F, Dupont, B
Fluconazole (FCZ) has been extensively used as a primary therapy for oropharyngeal candidosis in AIDS patients. Clinical resistance to FCZ is now encountered, often related to decreased...
Antifungal prophylaxis during neutropenia and immunodeficiency.
Fungal infections represent a major source of morbidity and mortality in patients with almost all types of immunodeficiencies. These infections may be nosocomial (aspergillosis) or community acquired...
Entry of ketoconazole into Candida albicans.
Boiron, P, Drouhet, E, Dupont, B, Improvisi, L
To define characteristics that determine the entry of ketoconazole (KTZ) into Candida albicans cells, we studied the uptake of [3H]KTZ. The cells rapidly and markedly concentrated the drug: 30% of...
Standardized susceptibility testing of fluconazole: an international collaborative study.
Pfaller, M A, Dupont, B, Kobayashi, G S, Müller, J, Rinaldi, M G, Espinel-Ingroff, A, ...
An international collaborative study of broth dilution (MIC) and disk diffusion susceptibility testing of fluconazole was conducted by using a chemically defined medium (High-Resolution Antifungal...
DNA typing suggests pigeon droppings as a source of pathogenic Cryptococcus neoformans serotype D.
Garcia-Hermoso, D, Mathoulin-Pélissier, S, Couprie, B, Ronin, O, Dupont, B, Dromer, F
The unusual proportion of serotype D strains of Cryptococcus neoformans infecting patients diagnosed with cryptococcosis in some parts of France prompted the analysis of DNA fingerprints obtained...
Dromer, F, Gueho, E, Ronin, O, Dupont, B
The importance of epidemiological studies of cryptococcosis has increased since the beginning of the AIDS epidemic. Cryptococcus neoformans exists in two varieties defining four serotypes,...
Molecular typing of Cryptococcus neoformans serotype D clinical isolates.
Dromer, F, Varma, A, Ronin, O, Mathoulin, S, Dupont, B
Cryptococcus neoformans serotype A is responsible for the majority of cryptococcal infections in AIDS patients. In France, approximately 17% of the patients are infected with serotype D, regardless...
Candida albicans genotyping in studies with patients with AIDS developing resistance to fluconazole.
Bart-Delabesse, E, Boiron, P, Carlotti, A, Dupont, B
We characterized Candida albicans strains responsible for recurrent oropharyngeal candidosis (OPC) in four patients with AIDS who developed clinical and mycological resistance to fluconazole (FCZ)....
Characterization of frequent deletions causing steroid 21-hydroxylase deficiency.
White, P C, Vitek, A, Dupont, B, New, M I
Steroid 21-hydroxylase deficiency is caused by mutations in the CYP21B gene. This gene and a highly homologous pseudogene, CYP21A, alternate with the C4A and C4B genes encoding the fourth component...
Molecular cloning of an inducible serine esterase gene from human cytotoxic lymphocytes.
Trapani, J A, Klein, J L, White, P C, Dupont, B
A cDNA clone encoding a human serine esterase gene was isolated from a library constructed from poly(A)+ RNA of allogeneically stimulated, interleukin 2-expanded peripheral blood mononuclear cells....
Structure of human steroid 21-hydroxylase genes.
White, P C, New, M I, Dupont, B
We have determined the structure of cDNA and two genomic genes encoding steroid 21-hydroxylase [21-OHase; steroid 21-monooxygenase; steroid, hydrogen-donor:oxygen oxidoreductase (21-hydroxylating);...
Two HLA-linked loci controlling the fourth component of human complement.
O'Neill, G J, Yang, S Y, Dupont, B
An electrophoretic polymorphism of the fourth component of human complement (C4) is described. Three patterns of bands of C4 were observed in EDTA plasma from a panel of unrelated blood donors and...
White, P C, New, M I, Dupont, B
We isolated a cDNA clone encoding a bovine adrenal cytochrome P-450 specific for steroid 21-hydroxylation (P-450C21). Serum from rabbits immunized with purified P-450C21 precipitated a single protein...
Evidence for tryosine peptide homologies in the HLA antigens system.
Cunningham-Rundles, C, Jersild, C, Svejgaard, A, Dupont, B, Good, R A
The tetrameric HLA antigens are composed of two heavier chains which carry the alloantigenic determinants and two lighter chains identified as beta2-microglobulin. Although at least 40 different...
Rosenkrantz, K, Dupont, B, Flomenberg, N
Using limiting dilution analysis, we have detected both the generation and suppression of autocytotoxic cells following autologous or allogeneic stimulation in vitro. Assay conditions were...
White, P C, New, M I, Dupont, B
We have determined the molecular genetic basis of congenital adrenal hyperplasia due to 21-hydroxylase (21-OHase) deficiency. This common disorder of cortisol biosynthesis is HLA-linked. The...
White, P C, Grossberger, D, Onufer, B J, Chaplin, D D, New, M I, Dupont, B, ...
Two genes encoding steroid 21-hydroxylase [21-OHase; steroid 21-monooxygenase; steroid, hydrogen-donor: oxygen oxidoreductase (21-hydroxylating); EC 1.14.99.10], a cytochrome P-450 enzyme, have been...
Broxmeyer, H E, Juliano, L, Lu, L, Platzer, E, Dupont, B
Acidic isoferritins, which under normal conditions are released from monocytes and macrophages, have a suppressive effect in vitro on granulocyte-macrophage, erythroid, and multipotential...
Górski, A J, Dupont, B, Hansen, J A, Good, R A
A standardized microculture system has been developed to assess the ability of lymphocytes to secrete leukocyte migration inhibitory factor (LMIF) in response to the nonspecific mitogen...
Chouaib, S, Robb, R J, Welte, K, Dupont, B
We have investigated the inhibitory potential of prostaglandin E2 (PGE2) with respect to intracellular messengers implicated in the signaling system of T-lymphocyte activation pathway. Using the...
Young, J W, Koulova, L, Soergel, S A, Clark, E A, Steinman, R M, Dupont, B
T cells respond to peptide antigen in association with MHC products on antigen-presenting cells (APCs). A number of accessory or costimulatory molecules have been identified that also contribute to T...
Mixed lymphocyte culture determinants, measles infection and multiple sclerosis.
Platz, P, Dupont, B, Fog, T, Ryder, L, Thomsen, M, Svejgaard, A, ...
Frequent deletion and duplication of the steroid 21-hydroxylase genes.
Werkmeister, J W, New, M I, Dupont, B, White, P C
Congenital adrenal hyperplasia due to 21-hydroxylase (21-OHase) deficiency is an HLA-linked disorder resulting from a mutation in the 21-OHase B gene encoding the adrenal cytochrome P450 specific for...
High frequency of nonclassical steroid 21-hydroxylase deficiency.
Speiser, P W, Dupont, B, Rubinstein, P, Piazza, A, Kastelan, A, New, M I
Nonclassical steroid 21-hydroxylase deficiency is an autosomal recessive disorder that is defined by clinical and hormonal criteria that distinguishes it from the classical 21-hydroxylase deficiency....
Pollack, M S, Levine, L S, O'Neill, G J, Pang, S, Lorenzen, F, Kohn, B, ...
Classical congenital adrenal hyperplasia due to 21-hydroxylase deficiency (21-OH-def) has been established to be an HLA-linked, recessive monogenetic disease. However, two nonclassical forms of...
Enhanced clonability of human T lymphocytes caused by their culturing in vitro.
Górski, A, Gaciong, Z, Dupont, B
Human lymphocytes precultured for 24--48 hr form more T-lymphoid colonies (LT-CFU) in agar than do fresh cells. It appears that during the preculture period lymphocytes proceed from G0 to the next S...
Ecotaxis: the principle and its application to the study of Hodgkin's disease.
Sousa, M D, Yang, M, Lopes-Corrales, E, Tan, C, Hansen, J A, Dupont, B, ...
A study of the function, characterization and distribution of T and B lymphocytes in five children with Hodgkin's disease is presented. The results, indicating that lymphocyte depletion in the...
Górski, A J, Dupont, B, Hansen, J A, O'Reilly, R, Smithwick, E, Górska, R, ...
Lymphocytes from patients with primary and secondary immunodeficiency disease were tested for capacity to produce LMIF after mitogen and antigen stimulation as well as for ability to stimulate and...
Jewett, M A, Gupta, S, Hansen, J A, Cunningham-Rundles, S, Siegal, F P, Good, R A, ...
The responses of fresh and frozen lymphocytes to mitogens and antigens have been compared using samples collected on five separate occasions from one normal donor. The day-to-day variation seen with...
SUZUKI, T, TAI, H, YOSHIE, H, JEANNEL, D, FOURNIER, S, DUPONT, B, ...
In an attempt to clarify the immunobiological events featuring periodontitis lesions of AIDS patients in the late stage of the disease, peripheral blood (PB) and gingival crevicular fluid (GCF)...
Vervoort, V, Viljoen, D, Smart, R, Suthers, G, DuPont, B, Abbott, A, ...
A patient with microcephaly, microphthalmia, ectrodactyly, and prognathism (MMEP) and mental retardation was previously reported to carry a de novo reciprocal t(6;13)(q21;q12) translocation. In an...
In vitro synergy and antagonism of antifungal agents against yeast-like fungi.
Some antifungal agents have been tested qualitatively in various associations against species of Candida, Cryptococcus and Torulopsis. The method used was the channel test and the results are...