ADHD and DAT1: further evidence of paternal over-transmission of risk alleles and haplotype (2009)
Hawi, Z., Kent, L., Hill, M., Anney, R.J.L., Brookes, K.J., Barry, E., ...
We [Hawi et al. (2005); Am J Hum Genet 77:958-965] reported paternal over-transmission of risk alleles in some ADHD-associated genes. This was particularly clear in the case of the DAT1 3-UTR VNTR....
Sonuga-Barke, E., Oades, R.D., Psychogiou, L., Chen, W., Franke, B., Buitelaar, J., ...
Background: Mothers' positive emotions expressed about their children with attention deficit/hyperactivity disorder (ADHD) are associated with a reduced likelihood of comorbid conduct problems (CP)....
Genetic heterogeneity in ADHD: DAT1 gene only affects probands without CD (2008)
Zhou, K., Chen, W., Buitelaar, J., Banaschewski, T., Oades, R.D., Franke, B., ...
Previous studies have found heterogeneous association between DAT1-3-UTR-VNTR and attention deficit hyperactivity disorder (ADHD). Various proportions of conduct disorder (CD) comorbidity in their...
Replication of a rare protective allele in the noradrenaline transporter gene and ADHD (2008)
Xu, X., Hawi, Z., Brookes, K.J., Anney, R., Bellgrove, M., Franke, B., ...
Replication is a key to resolving whether a reported genetic association represents a false positive finding or an actual genetic risk factor. In a previous study screening 51 candidate genes for...
Brookes, K.J., Xu, X., Anney, R., Franke, B., Zhou, K., Chen, Wai, ...
Multiple studies have reported an association between attention deficit hyperactivity disorder (ADHD) and the 10-repeat allele of a variable number tandem repeat (VNTR) polymorphism in the...
Zhou, K., Asherson, P., Sham, P., Franke, B., Anney, R.J., Buitelaar, J., ...
Background Limited success has been achieved through previous attention-deficit/hyperactivity disorder (ADHD) linkage scans, which were all designed to map genes underlying the dichotomous phenotype....
Christiansen, H., Chen, W., Oades, R.D., Asherson, P., Taylor, E.A., Lasky-Su, J., ...
Common disorders of childhood and adolescence are attention-deficit/hyperactivity disorder (ADHD), oppositional defiant disorder (ODD) and conduct disorder (CD). For one to two cases in three...
Asherson, P., Zhou, K., Anney, R.J.L., Franke, B., Buitelaar, J., Ebstein, R., ...
As part of the International Multi-centre ADHD Genetics project we completed an affected sibling pair study of 142 narrowly defined Diagnostic and Statistical Manual of Mental Disorders, fourth...
Brookes, K.J., Neale, B., Xu, X., Thapar, A., Gill, M., Langley, K., ...
Season of birth (SOB) has been associated with attention deficit hyperactivity disorder (ADHD) in two existing studies. One further study reported an interaction between SOB and genotypes of the...
Kooij, J.S., Boonstra, A.M., Vermeulen, S.H., Heister, A.G., Burger, H., Buitelaar, J.K., ...
In this pharmacogenetic study in adults with ADHD (n = 42), a stratified analysis was performed of the association between response to methylphenidate (MPH), assessed under double-blind conditions,...
Kooij, J.S., Boonstra, A.M., Vermeulen, S.H., Heister, A.G., Burger, H., Buitelaar, J.K., ...
In this pharmacogenetic study in adults with ADHD (n = 42), a stratified analysis was performed of the association between response to methylphenidate (MPH), assessed under double-blind conditions,...
Population differences in the international multi-centre ADHD gene project (2008)
Neale, B.M., Sham, P.C., Purcell, S., Banaschewski, T., Buitelaar, J., Franke, B., ...
The International Multi-Centre ADHD Gene sample consists of 674 families from eight countries (Belgium, England, Germany, Holland, Ireland, Israel, Spain, and Switzerland) ascertained from clinics...
Chen, W., Zhou, K., Sham, P., Franke, B., Kuntsi, J., Campbell, D., ...
Attention deficit hyperactivity disorder (ADHD) is a discrete clinical syndrome characterized by the triad of inattention, hyperactivity, and impulsivity in the context of marked impairments....
Xu, X., Aysimi, E., Anney, R., Brookes, K., Franke, B., Zhou, K., ...
Several independent studies have reported association between serotonin transporter gene (SLC6A4) polymorphisms and attention deficit hyperactivity disorder (ADHD). Five studies found evidence for...
Population differences in the International Multi-Centre ADHD Gene project (2008)
NEALE, BM, SHAM, PC, PURCELL, S, BANASCHEWSKI, T, BUITELAAR, J, FRANKE, B, ...
ASHERSON, P, ZHOU, K, ANNEY, RJL, FRANKE, B, BUITELAAR, J, EBSTEIN, R, ...
Genome-Wide Association Scan of Attention Deficit Hyperactivity Disorder (2008)
NEALE, BM, LASKY-SU, J, ANNEY, R, FRANKE, B, ZHOU, KX, MALLER, JB, ...
LASKY-SU, J, NEALE, BM, FRANKE, B, ANNEY, RJL, ZHOU, KX, MALLER, JB, ...
Genome-Wide Association Scan of the Time to Onset of Attention Deficit Hyperactivity Disorder (2008)
LASKY-SU, J, ANNEY, RJL, NEALE, BM, FRANKE, B, ZHOU, K, MALLER, JB, ...
ANNEY, RJL, HAWI, Z, SHEEHAN, K, MULLIGAN, A, PINTO, C, BROOKES, KJ, ...
Replication of a Rare Protective Allele in the Noradrenaline Transporter Gene and ADHD (2008)
XU, X, HAWI, Z, BROOKES, KJ, ANNEY, R, BELLGROVE, M, FRANKE, B, ...
ZHOU, KX, ASHERSON, P, SHAM, P, FRANKE, B, ANNEY, RJL, BUITELAAR, J, ...
Meta-Analysis of Genome-Wide Linkage Scans of Attention Deficit Hyperactivity Disorder (2008)
ZHOU, KX, DEMPFLE, A, ARCOS-BURGOS, M, BAKKER, SC, BANASCHEWSKI, T, BIEDERMAN, J, ...
Genetic Heterogeneity in ADHD: DAT1 Gene Only Affects Probands Without CD (2008)
ZHOU, KX, CHEN, W, BUITELAAR, J, BANASCHEWSKI, T, OADES, RD, FRANKE, B, ...
Brookes, K.J., Neale, B., Xu, X., Thapar, A., Gill, M., Langley, K., ...
Season of birth (SOB) has been associated with attention deficit hyperactivity disorder (ADHD) in two existing studies. One further study reported an interaction between SOB and genotypes of the...
Lasky-Su, J., Neale, B.M., Franke, B., Anney, R.J.L., Zhou, K., Maller, J.B., ...
Attention deficit hyperactivity disorder (ADHD) is a complex condition with environmental and genetic etiologies. Up to this point, research has identified genetic associations with candidate genes...
Fliers, E., Rommelse, N., Altink, M., Buschgens, C.J.M., Faraone, S.V., ...
Summary. Objective. ADHD is frequently accompanied by motor coordination problems. However, the co-occurrence of poor motor performance has received less attention in research than other coexisting...
Lasky-Su, J., Banaschewski, T., Buitelaar, J., Franke, B., Brookes, K., Sonuga-Barke, E., ...
Background: Lisdexamfetamine dimesylate is a therapeutically inactive prodrug in which d-amphetamine is covalently bound to l-lysine, a naturally occurring amino acid. Pharmacologically active...
Lasky-Su, J., Banaschewski, T., Buitelaar, J., Franke, B., Brookes, K., Sonuga-Barke, E., ...
Background Previous research found an association between single nucleotide polymorphisms (SNPs) in the promoter region of DRD4 and statistically derived phenotypes generated from...
A superfluid helium converter for accumulation and extraction of ultracold neutrons (2007)
Zimmer, O., Baumann, K., Fertl, M., Franke, B., Mironov, S., Plonka, C., ...
We report the first successful extraction of accumulated ultracold neutrons (UCN) from a converter of superfluid helium, in which they were produced by downscattering neutrons of a cold beam from the...
Mulder, Johannes, Franke, B., Arends, J., Wilmink, F.W., Scheffer, H, ...
The use of antipsychotics is associated with metabolic side effects, which put patients with schizophrenia or related disorders at risk for cardiovascular morbidity. The high interindividual...
ASHERSON, P, BROOKES, K, FRANKE, B, CHEN, W, GILL, M, EBSTEIN, RP, ...
Brookes, K, Xu, X, Chen, W, Zhou, K, Neale, B, Lowe, N, ...
Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder, starting in early childhood and persisting into adulthood in the majority of cases. Family and twin studies...
Mochtar, C.A., Laan, W., Houwelingen, K.P. Van, Franke, B., Schalken, J.A., ...
To determine whether a common single nucleotide polymorphism (SNP) in the ADRA1A gene encoding the alpha(1A)-adrenoceptor modifies the short- and long-term efficacy of alpha(1)-adrenoceptor...
Brookes, K., Xu, X., Chen, W., Zhou, K., Neale, B., Lowe, N., ...
Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder, starting in early childhood and persisting into adulthood in the majority of cases. Family and twin studies...
Using machine learning to focus iterative optimization (2006)
F. Agakov, E. Bonilla, J. Cavazos, B. Franke, G. Fursin, ...
Using Machine Learning to Focus Iterative Optimization (2006)
Agakov Bonilla Cavazos, F. Agakov, E. Bonilla, J. Cavazos, B. Franke, G. Fursin, ...
Iterative compiler optimization has been shown to outperform static approaches. This, however, is at the cost of large numbers of evaluations of the program. This paper develops a new methodology to...
Using machine learning to focus iterative optimization (2006)
F. Agakov, E. Bonilla, J. Cavazos, B. Franke, G. Fursin, ...
Iterative compiler optimization has been shown to outperform static approaches. This, however, is at the cost of large numbers of evaluations of the program. This paper develops a new methodology to...
Radstake, TRDJ, Franke, B, Hanssen, S, Welsing, P, Joosten, LAB, Van Riel, PLCM, ...
No abstract available.
Kaimer, M., Schade, D., [Hrsg.], Ballschmiter, K., Barniske, L., Berghoff, R., ...
Berlin : Erich Schmidt, 1999
Chlorine monoxide radiometer intercomparison in Ny-Alesund, 1997 (1998)
Klein, U., Franke, B., Langer, J., Raffalski, U., Sinnhuber, B.M., Künzi, K.F., ...
Harris, N.R.P. [Hrsg.]
Rapid Ca2+-mediated activation of Rap1 in human platelets.
Franke, B, Akkerman, J W, Bos, J L
Rap1 is a small, Ras-like GTPase whose function and regulation are still largely unknown. We have developed a novel assay to monitor the active, GTP-bound form of Rap1 based on the differential...
Extracellular signal-regulated activation of Rap1 fails to interfere in Ras effector signalling.
Zwartkruis, F J, Wolthuis, R M, Nabben, N M, Franke, B, Bos, J L
The small GTPase Rap1 has been implicated in both negative and positive control of Ras-mediated signalling events. We have investigated which extracellular signals can activate Rap1 and whether this...
Low-density lipoprotein activates the small GTPases Rap1 and Ral in human platelets.
Hackeng, C M, Franke, B, Relou, I A, Gorter, G, Bos, J L, Van Rijn , H J, ...
Physiological concentrations of low-density lipoprotein (LDL) sensitize blood platelets to alpha-thrombin- and collagen-induced secretion, and after prolonged contact trigger secretion independent of...
Rapid Ca2+-mediated activation of Rap1 in human platelets.
Franke, B, Akkerman, J W, Bos, J L
Rap1 is a small, Ras-like GTPase whose function and regulation are still largely unknown. We have developed a novel assay to monitor the active, GTP-bound form of Rap1 based on the differential...
Extracellular signal-regulated activation of Rap1 fails to interfere in Ras effector signalling.
Zwartkruis, F J, Wolthuis, R M, Nabben, N M, Franke, B, Bos, J L
The small GTPase Rap1 has been implicated in both negative and positive control of Ras-mediated signalling events. We have investigated which extracellular signals can activate Rap1 and whether this...
Low-density lipoprotein activates the small GTPases Rap1 and Ral in human platelets.
Hackeng, C M, Franke, B, Relou, I A, Gorter, G, Bos, J L, Van Rijn , H J, ...
Physiological concentrations of low-density lipoprotein (LDL) sensitize blood platelets to alpha-thrombin- and collagen-induced secretion, and after prolonged contact trigger secretion independent of...
Riksen, N P, Franke, B, Oyen, W J G, Boerman, O C, Smits, P, ...
Genetic variation analysis of MLP, TFAP2A, and CSK in patients with neural tube defects
Klootwijk, R, Hol, F, Wu, M, Willemen, J, Groenen, P, Hamel, B, ...
Genomewide scan identifies susceptibility locus for dyslexia on Xq27 in an extended Dutch family
Hol, F, Heister, J, Willemen, J, Sandkuijl, L, Franke, B, ...
Context: Dyslexia is a common disorder with a strong genetic component, but despite significant research effort, the aetiology is still largely unknown.