B. Hang

Hepatoprotective Activity Evaluation Of Cichorium glandulosum (2008)

Abulimiti, Y, Hankui, W U, Akber Aisa, H, Kasimu, R, Hang, B

The EtOAc and n-BuOH extracts of Cichorium glandulosum were tested for hepatoprotective activity against paracetamol-induced hepatotoxicities in mice. C. gladulosum exhibited significant...

An unusual mechanism for the major human apurinic/apyrimidinic (AP) endonuclease involving 5′ cleavage of DNA containing a benzene-derived exocyclic adduct in the absence of an AP site

Hang, B., Chenna, A., Fraenkel-Conrat, H., Singer, B.

The major human apurinic/apyrimidinic (AP) endonuclease (class II) is known to cleave DNA 5′ adjacent to an AP site, which is probably the most common DNA damage produced hydrolytically or by...

Targeted deletion of alkylpurine-DNA-N-glycosylase in mice eliminates repair of 1,N6-ethenoadenine and hypoxanthine but not of 3,N4-ethenocytosine or 8-oxoguanine

Hang, B., Singer, B., Margison, G. P., Elder, R. H.

It has previously been reported that 1,N6-ethenoadenine (ɛA), deaminated adenine (hypoxanthine, Hx), and 7,8-dihydro-8-oxoguanine (8-oxoG), but not 3,N4-ethenocytosine (ɛC), are released from DNA...

A 55-kDa protein isolated from human cells shows DNA glycosylase activity toward 3,N4-ethenocytosine and the G/T mismatch

Hang, B., Medina, M., Fraenkel-Conrat, H., Singer, B.

Etheno adducts in DNA arise from multiple endogenous and exogenous sources. Of these adducts we have reported that, 1,N6-ethenoadenine (ɛA) and 3,N4-ethenocytosine (ɛC) are removed from DNA by two...

The benzene metabolite p-benzoquinone forms adducts with DNA bases that are excised by a repair activity from human cells that differs from an ethenoadenine glycosylase.

Chenna, A, Hang, B, Rydberg, B, Kim, E, Pongracz, K, Bodell, W J, ...

Benzene is a ubitiquous human environment mental carcinogen. One of the major metabolites is hydroquinone, which is oxidized in vivo to give p-benzoquinone (p-BQ). Both metabolites are toxic to human...

Substitution of Asp-210 in HAP1 (APE/Ref-1) eliminates endonuclease activity but stabilises substrate binding

Rothwell, D. G., Hang, B., Gorman, M. A., Freemont, P. S., Singer, B., Hickson, I. D.

HAP1, also known as APE/Ref-1, is the major apurinic/apyrimidinic (AP) endonuclease in human cells. Previous structural studies have suggested a possible role for the Asp-210 residue of HAP1 in the...

A damage-recognition protein which binds to DNA containing interstrand cross-links is absent or defective in Fanconi anemia, complementation group A, cells.

Hang, B, Yeung, A T, Lambert, M W

A DNA binding protein with specificity for DNA containing interstrand cross-links induced by 4,5',8-trimethylpsoralen (TMP) plus long wavelength ultraviolet (UVA) light has been identified in normal...

An unusual mechanism for the major human apurinic/apyrimidinic (AP) endonuclease involving 5′ cleavage of DNA containing a benzene-derived exocyclic adduct in the absence of an AP site

Hang, B., Chenna, A., Fraenkel-Conrat, H., Singer, B.

The major human apurinic/apyrimidinic (AP) endonuclease (class II) is known to cleave DNA 5′ adjacent to an AP site, which is probably the most common DNA damage produced hydrolytically or by...

Targeted deletion of alkylpurine-DNA-N-glycosylase in mice eliminates repair of 1,N6-ethenoadenine and hypoxanthine but not of 3,N4-ethenocytosine or 8-oxoguanine

Hang, B., Singer, B., Margison, G. P., Elder, R. H.

It has previously been reported that 1,N6-ethenoadenine (ɛA), deaminated adenine (hypoxanthine, Hx), and 7,8-dihydro-8-oxoguanine (8-oxoG), but not 3,N4-ethenocytosine (ɛC), are released from DNA...

A 55-kDa protein isolated from human cells shows DNA glycosylase activity toward 3,N4-ethenocytosine and the G/T mismatch

Hang, B., Medina, M., Fraenkel-Conrat, H., Singer, B.

Etheno adducts in DNA arise from multiple endogenous and exogenous sources. Of these adducts we have reported that, 1,N6-ethenoadenine (ɛA) and 3,N4-ethenocytosine (ɛC) are removed from DNA by two...

The benzene metabolite p-benzoquinone forms adducts with DNA bases that are excised by a repair activity from human cells that differs from an ethenoadenine glycosylase.

Chenna, A, Hang, B, Rydberg, B, Kim, E, Pongracz, K, Bodell, W J, ...

Benzene is a ubitiquous human environment mental carcinogen. One of the major metabolites is hydroquinone, which is oxidized in vivo to give p-benzoquinone (p-BQ). Both metabolites are toxic to human...

Substitution of Asp-210 in HAP1 (APE/Ref-1) eliminates endonuclease activity but stabilises substrate binding

Rothwell, D. G., Hang, B., Gorman, M. A., Freemont, P. S., Singer, B., Hickson, I. D.

HAP1, also known as APE/Ref-1, is the major apurinic/apyrimidinic (AP) endonuclease in human cells. Previous structural studies have suggested a possible role for the Asp-210 residue of HAP1 in the...

A damage-recognition protein which binds to DNA containing interstrand cross-links is absent or defective in Fanconi anemia, complementation group A, cells.

Hang, B, Yeung, A T, Lambert, M W

A DNA binding protein with specificity for DNA containing interstrand cross-links induced by 4,5',8-trimethylpsoralen (TMP) plus long wavelength ultraviolet (UVA) light has been identified in normal...