Networks: A New Summation Law (2007)
M. A. Peletier, H. V. Westerhoff, B. N. Kholodenko, Mark A. Peletier, Hans V. Westerhoff, Boris N. Kholodenko
Control of spatially heterogeneous and time-varying cellular reaction networks: a new summation law
Saez-Rodriguez,J., Conzelmann,H., Sauter,T., Kholodenko,B. N., Gilles,E. D.
A rigorous, detailed description of signaling networks gives rise to huge models, while an a priori simplified model relies on assumptions difficult to prove. Therefore, models which are manageable,...
Saez-Rodriguez, J., Conzelmann, H., Sauter, T., Kholodenko, B. N., Gilles, E. D.
A rigorous, detailed description of signaling networks gives rise to huge models, while an a priori simplified model relies on assumptions difficult to prove. Therefore, models which are manageable,...
Cellular information transfer regarded from a stoichiometry and control analysis perspective. (2000)
Metabolic control from the back benches: Biochemistry towards biocomplexity (2000)
Westerhoff, H.V., Teusink, B., Mensonides, F.I.C., Reijenga, K.A., Esgalhado, E., Kholodenko, B.N., ...
Control analysis of metabolic systems involving quasi-equilibrium reactions. (1999)
Kholodenko, B.N., Garcia, J., Westerhoff, H.V., Cascante, M.
Thermodynamics of complexity. The live cell (1998)
Westerhoff, H.V., Jensen, P.R., Snoep, J.L., Kholodenko, B.N.
Inplications of macromolecular crowding for signal transduction and metabolite channeling (1998)
Rohwer, J.M., Postma, P.W., Kholodenko, B.N., Westerhoff, H.V.
Hierarchical control of electron-transfer (1998)
Westerhoff, H.V., Jensen, P.R., Egger, L., Heeswijk, W.C. Van, Kholodenko, B.N., ...
BTK traditions and perspectives: Complex biothermokinetics and control analysis (1998)
Westerhoff, H.V., Rotterdam, B.J. Van, Heeswijk, W.C. Van, Kholodenko, B.N.
Thermodynamics of complexity. The live cell (1997)
Westerhoff, H.V., Jensen, P.R., Snoep, J.L., Kholodenko, B.N.
Direct transfer of control and multidrug resistance (1996)
Westerhoff, H.V., Rohwer, J.M., Heijn, M., Mulder, S., Ghauharali, R.I., Wielinga, P., ...
Control of dynamics and steady state: applications to multidrug resistance (1996)
Westerhoff, H.V., Bier, M., Molenaar, D., Spoelstra, E.C., Lankelma, J., Jongsma, A.P.M., ...
Nonlinear control and self-organization (1996)
Westerhoff, H.V., Jensen, P.R., Kahn, D., Kholodenko, B.N., Richard, P.
Protein-protein interactions, metabolite channelling, and the control flux (1996)
Rohwer, J.M., Westerhoff, H.V., Kholodenko, B.N., Postma, P.W.
Control and regulation of channelled versus ideal pathways (1996)
Kholodenko, B.N., Cascante, M., Westerhoff, H.V., Kushmerick, M.J.
Strong control on the transit time in metabolic channelling (1996)
Kholodenko, B.N., Sakamoto, N., Puigjaner, J., Westerhoff, H.V., Cascante, M.
Molecular biology for flux control (1995)
Jensen, P.R., Snoep, J.L., Molenaar, D., Heeswijk, W.C. Van, Kholodenko, B.N., ...
Dynamic aspects of cascade-type metabolic regulation (1995)
Molenaar, D., Kholodenko, B.N., Heeswijk, W.C. Van, Westerhoff, H.V.
Control in channelled pathways. A matrix method calculating the enzyme control coefficients (1995)
Kholodenko, B.N., Westerhoff, H.V., Puigjaner, J., Cascante, M.
Energy, control and DNA structure in the living cell. (1995)
Wijker, J.E., Jensen, P.R., Vaz Gomes, A., Waal, A. De, Workum, M. Van, Heeswijk, W.C. Van, ...
Control theory of cell metabolism: towards more realistic "non-ideal" systems. (1995)
Kholodenko, B.N., Cascante, M., Molenaar, D., Demin, O.V., Westerhoff, H.V.
Defining control coefficients in non-ideal metabolic pathways (1995)
Kholodenko, B.N., Molenaar, D., Schuster, S., Heinrich, R., Westerhoff, H.V.
Multiplicity of control. (1994)
Westerhoff, H.V., Jensen, P.R., Kahn, D., Kholodenko, B.N., Schuster, S., ...
Domain-oriented and modular approaches to the reduction of mathematical models of signaling networks
Saez-Rodriguez,J., Conzelmann,H., Sauter,T., Kholodenko,B. N., Gilles,E. D.
A rigorous, detailed description of signaling networks gives rise to huge models, while an a priori simplified model relies on assumptions difficult to prove. Therefore, models which are manageable,...
Kholodenko, B N, Westerhoff, H V, Cascante, M
This paper shows that metabolic channelling can provide a mechanism for decreasing the concentration of metabolites in the cytoplasm when cytosolic proteins become more concentrated. A dynamic...
It is widely assumed that within a metabolic pathway inhibition of an enzyme causes the control exerted by that enzyme over the flux through its own reaction to increase, whereas activation causes...
Diffusion control of protein phosphorylation in signal transduction pathways.
Kholodenko, B N, Brown, G C, Hoek, J B
Multiple signalling proteins are phosphorylated and dephosphorylated at separate cellular locations, which potentially causes spatial gradients of phospho-proteins within the cell. We have derived...
De Atauri, P, Acerenza, L, Kholodenko, B N, Guinovart, J J, Agius, L, ...
It is widely assumed that the control coefficient of an enzyme on pathway flux decreases as the concentration of enzyme increases. However, it has been shown [Kholodenko and Brown (1996) Biochem. J....
Kholodenko, B N, Westerhoff, H V, Cascante, M
This paper shows that metabolic channelling can provide a mechanism for decreasing the concentration of metabolites in the cytoplasm when cytosolic proteins become more concentrated. A dynamic...
It is widely assumed that within a metabolic pathway inhibition of an enzyme causes the control exerted by that enzyme over the flux through its own reaction to increase, whereas activation causes...
Diffusion control of protein phosphorylation in signal transduction pathways.
Kholodenko, B N, Brown, G C, Hoek, J B
Multiple signalling proteins are phosphorylated and dephosphorylated at separate cellular locations, which potentially causes spatial gradients of phospho-proteins within the cell. We have derived...
De Atauri, P, Acerenza, L, Kholodenko, B N, Guinovart, J J, Agius, L, ...
It is widely assumed that the control coefficient of an enzyme on pathway flux decreases as the concentration of enzyme increases. However, it has been shown [Kholodenko and Brown (1996) Biochem. J....
Domain-oriented and modular approaches to the reduction of mathematical models of signaling networks
Saez-Rodriguez, J., Conzelmann, H., Sauter, T., Kholodenko, B. N., Gilles, E. D.
A rigorous, detailed description of signaling networks gives rise to huge models, while an a priori simplified model relies on assumptions difficult to prove. Therefore, models which are manageable,...