Histopathology of portal hypertension: a practical guideline (2003)
Baptista, A, Bianchi, L, Burt, A, Callea, F, Denk, H, ...
Department of Pathology, K.U. Leuven, Leuven, Belgium. tania.rocksams@uz.kuleuven.ac.be
Guidelines for the diagnosis and interpretation of hepatic granulomas (1994)
Denk, H, Scheuer, PJ, Baptista, A, Bianchi, L, Callea, F, De Groote, Jan; U0005908, ...
BIRD, G. L. A., SMITH, HEATHER, PORTMANN, B., ALEXANDER, G. J. M., WILLIAMS, ROGER
Five chronic carriers of hepatitis B virus developed a fulminant hepatitis-like picture when immunosuppression or cytotoxic treatment, given for unrelated disorders, was withdrawn. Viral replication...
PROGRESSIVE NEURONAL DEGENERATION OF CHILDHOOD WITH LIVER DISEASE: A PATHOLOGICAL STUDY (1986)
HARDING, B. N., EGGER, J., PORTMANN, B., ERDOHAZI, M.
A clinicopathological study of 10 cases of progressive neuronal degeneration of childhood is reported. In the typical clinical course early developmental delay is followed by intractable epilepsy...
The Value of Liver Biopsy in Alcoholic Liver Disease (1982)
Liver biopsy is a value technique for providing reliable information with which to accurately classify patients with alcoholic liver disease. It is also the most accurate discriminator for...
Budd-Chiari Syndrome: Clinical Patterns and Therapy (1982)
POWELL-JACKSON, P. R., MELIA, W., CANALESE, J., PICKFORD, R. B., PORTMANN, B., WILLIAMS, ROGER
Retrospective analysis of 36 patients (25 women, 11 men) with the Budd-Chiari syndrome diagnosed between 1971 and 1980 showed a wide range in ages at presentation (12 to 68 years) with the peak...
Liver Disease as Presenting Manifestation of Hodgkin's Disease (1979)
TREWBY, P. N., PORTMANN, B., BRINKLEY, D. M., WILLIAMS, ROGER
Six patients who were referred to the liver unit on account of jaundice are described. A different initial diagnosis has been made in each case, these being fulminant hepatic failure, severe...
Clinical Course of Chronic Lobular Hepatitis: REPORT OF FIVE CASES (1978)
WILKINSON, S. P., PORTMANN, B., COCHRANE, A. M. G., TEE, D. E. H., WILLIAMS, ROGER
The clinical course, and biochemical, immunological, and liver histological changes in five patients with chronic lobular hepatitis are described. All were male (ages 17 to 44 years) and presented...
GAZZARD, B. G., PORTMANN, B., MUREAY-LYON, IAIN M., WILLIAMS, ROGER
The clinical course and causes of death in 132 consecutive patients with fulminant hepatic failure and grade III or IV encephalopathy have been reviewed. 105 patients died and in 96 of these an...
Nouri Aria, K T, Sallie, R, Sangar, D, Alexander, G J, Smith, H, Byrne, J, ...
Nonisotopic in situ hybridization using a digoxigenin-labeled cDNA probe to the 3' nonstructural region (NS5) of hepatitis C virus (HCV) was performed on liver tissue from 33 patients. The results...
Hadzic, N, Alberti, A, Portmann, B, Vergani, D
The presence of pre-S polypeptides in paraffin wax embedded liver sections from the biopsy specimens of 15 hepatitis B surface antigen (HBsAg) seropositive patients (five with chronic persistent...
Matsui, A, Psacharopoulos, H T, Mowat, A P, Portmann, B, Murphy, G M
Serum glycocholic acid (SGC) was measured by radioimmunoassay in 277 samples from 122 children with hepatobiliary disorders and from 23 healthy age-matched controls. In patients with hepatobiliary...
Value of copper-associated protein in diagnostic assessment of liver biopsy.
Guarascio, P, Yentis, F, Cevikbas, U, Portmann, B, Williams, R
Of 1361 consecutive liver biopsy specimens, 24% contained orcein-positive granules. The highest incidence of positivity was found in biliary disease (90.9%), long before cirrhosis had developed,...
Guarascio, P, Portmann, B, Visco, G, Williams, R
A patient with sudden onset of ascites and hepatosplenomegaly made a complete recovery after vitamin A was withdrawn. Fluorescence microscopy on embedded tissue provided a simple method of...
Hepatocellular carcinoma complicating chronic granulomatous hepatitis.
Melia, W M, Calvey, H, Portmann, B, Williams, R
The development of hepatocellular carcinoma, is reported in a patient with chronic granulomatous hepatitis after a seven year interval in which clinical and biochemical improvement had occurred on...
Wash off liver cytology: a complementary diagnostic tool to liver biopsy.
Vogel, W, Fagan, E A, Bomford, A, Portmann, B, Williams, R
Parenchymal and non-parenchymal cells were harvested by washing the liver tissue core and needle after percutaneous biopsy. The cytological material obtained was suitable for morphological analysis,...
Observations on Preservation, Bile Drainage and Rejection in 64 Human Orthotopic Liver Allografts
Calne, R. Y., McMaster, P., Portmann, B., Wall, W. J., Williams, Roger
The combined Cambridge/King's College Hospital series of 64 orthotopic liver grafts' experience dates back to 1968. Many patients were referred for liver grafting late in the course of their diseases...
Paradinas, F J, Melia, W M, Wilkinson, M L, Portmann, B, Johnson, P J, Murray-Lyon, I M, ...
Ten (9.3%) of 107 patients with hepatocellular carcinoma had considerably increased serum unsaturated vitamin B12 binding capacity. All 10 were young (mean 12 years), had no serum alpha-fetoprotein,...
Importance of markers of hepatitis B virus in alcoholic liver disease.
Saunders, J B, Wodak, A D, Morgan-Capner, P, White, Y S, Portmann, B, Davis, M, ...
To determine the importance of the presence of serological markers of hepatitis B virus infection in patients with alcohol related liver disease we compared cumulative alcohol intake and clinical and...
De novo acute infection and reactivation of hepatitis B virus in established cirrhosis.
Theodossi, A, Wilkinson, S P, Portmann, B, White, Y, Eddleston, A L, Williams, R, ...
Five patients with cirrhosis proved by biopsy had clinical, biochemical, and serological evidence of an acute hepatitis B infection. In two the illness was fulminant and led to death. Only one...
Renal failure in otherwise uncomplicated acute viral hepatitis.
Wilkinson, S P, Davies, M H, Portmann, B, Williams, R
Twelve patients with otherwise uncomplicated acute viral hepatitis (two were HBsAg-positive) developed renal failure. Apart from dehydration due to repeated vomiting in one patient, no factor...
Krasner, N, Davis, M, Portmann, B, Williams, R
A survey of 293 patients with alcoholic liver disease showed that women, particularly those aged under 45, had a significantly higher incidence of alcoholic hepatitis, with or without superimposed...
Johnson, P J, Portmann, B, Williams, R
Serum alpha-fetoprotein (AFP) concentrations were estimated by sensitive radioimmunoassay in 30 patients with cirrhosis complicated by hepatocellular carcinoma and in 100 patients with cirrhosis in...
Tsantoulas, D. C., McFarlane, I. G., Portmann, B., Williams, Roger
Cell-mediated immune responses to Tamm-Horsfall glycoprotein isolated from human urine were investigated using the leucocyte migration test. Abnormal responses were found in 91% of patients with...
Galbraith, R M, El Sheikh, N, Portmann, B, Eddleston, A L, Williams, R, Parsons, V, ...
Evidence of chronic hepatitis was found on histological examination in nine out of 15 patients positive for hepatitis-B surface antigen (HBsAg) who had either chronic renal failure or a functioning...
Histological evidence of carcinoma in a hepatic tumour associated with oral contraceptives.
Davis, M, Portmann, B, Searle, M, Wright, R, Williams, R
A primary hepatic tumour occurred in a 21-year-old woman who had been taking oral contraceptives for two years; she was treated by partial hepatectomy. Part of the neoplasm showed features suggestive...
Nouri Aria, K T, Sallie, R, Sangar, D, Alexander, G J, Smith, H, Byrne, J, ...
Nonisotopic in situ hybridization using a digoxigenin-labeled cDNA probe to the 3' nonstructural region (NS5) of hepatitis C virus (HCV) was performed on liver tissue from 33 patients. The results...
Hadzic, N, Alberti, A, Portmann, B, Vergani, D
The presence of pre-S polypeptides in paraffin wax embedded liver sections from the biopsy specimens of 15 hepatitis B surface antigen (HBsAg) seropositive patients (five with chronic persistent...
Matsui, A, Psacharopoulos, H T, Mowat, A P, Portmann, B, Murphy, G M
Serum glycocholic acid (SGC) was measured by radioimmunoassay in 277 samples from 122 children with hepatobiliary disorders and from 23 healthy age-matched controls. In patients with hepatobiliary...
Value of copper-associated protein in diagnostic assessment of liver biopsy.
Guarascio, P, Yentis, F, Cevikbas, U, Portmann, B, Williams, R
Of 1361 consecutive liver biopsy specimens, 24% contained orcein-positive granules. The highest incidence of positivity was found in biliary disease (90.9%), long before cirrhosis had developed,...
Guarascio, P, Portmann, B, Visco, G, Williams, R
A patient with sudden onset of ascites and hepatosplenomegaly made a complete recovery after vitamin A was withdrawn. Fluorescence microscopy on embedded tissue provided a simple method of...
Hepatocellular carcinoma complicating chronic granulomatous hepatitis.
Melia, W M, Calvey, H, Portmann, B, Williams, R
The development of hepatocellular carcinoma, is reported in a patient with chronic granulomatous hepatitis after a seven year interval in which clinical and biochemical improvement had occurred on...
Wash off liver cytology: a complementary diagnostic tool to liver biopsy.
Vogel, W, Fagan, E A, Bomford, A, Portmann, B, Williams, R
Parenchymal and non-parenchymal cells were harvested by washing the liver tissue core and needle after percutaneous biopsy. The cytological material obtained was suitable for morphological analysis,...
Observations on Preservation, Bile Drainage and Rejection in 64 Human Orthotopic Liver Allografts
Calne, R. Y., McMaster, P., Portmann, B., Wall, W. J., Williams, Roger
The combined Cambridge/King's College Hospital series of 64 orthotopic liver grafts' experience dates back to 1968. Many patients were referred for liver grafting late in the course of their diseases...
Paradinas, F J, Melia, W M, Wilkinson, M L, Portmann, B, Johnson, P J, Murray-Lyon, I M, ...
Ten (9.3%) of 107 patients with hepatocellular carcinoma had considerably increased serum unsaturated vitamin B12 binding capacity. All 10 were young (mean 12 years), had no serum alpha-fetoprotein,...
Importance of markers of hepatitis B virus in alcoholic liver disease.
Saunders, J B, Wodak, A D, Morgan-Capner, P, White, Y S, Portmann, B, Davis, M, ...
To determine the importance of the presence of serological markers of hepatitis B virus infection in patients with alcohol related liver disease we compared cumulative alcohol intake and clinical and...
De novo acute infection and reactivation of hepatitis B virus in established cirrhosis.
Theodossi, A, Wilkinson, S P, Portmann, B, White, Y, Eddleston, A L, Williams, R, ...
Five patients with cirrhosis proved by biopsy had clinical, biochemical, and serological evidence of an acute hepatitis B infection. In two the illness was fulminant and led to death. Only one...
Renal failure in otherwise uncomplicated acute viral hepatitis.
Wilkinson, S P, Davies, M H, Portmann, B, Williams, R
Twelve patients with otherwise uncomplicated acute viral hepatitis (two were HBsAg-positive) developed renal failure. Apart from dehydration due to repeated vomiting in one patient, no factor...
Krasner, N, Davis, M, Portmann, B, Williams, R
A survey of 293 patients with alcoholic liver disease showed that women, particularly those aged under 45, had a significantly higher incidence of alcoholic hepatitis, with or without superimposed...
Johnson, P J, Portmann, B, Williams, R
Serum alpha-fetoprotein (AFP) concentrations were estimated by sensitive radioimmunoassay in 30 patients with cirrhosis complicated by hepatocellular carcinoma and in 100 patients with cirrhosis in...
Tsantoulas, D. C., McFarlane, I. G., Portmann, B., Williams, Roger
Cell-mediated immune responses to Tamm-Horsfall glycoprotein isolated from human urine were investigated using the leucocyte migration test. Abnormal responses were found in 91% of patients with...
Galbraith, R M, El Sheikh, N, Portmann, B, Eddleston, A L, Williams, R, Parsons, V, ...
Evidence of chronic hepatitis was found on histological examination in nine out of 15 patients positive for hepatitis-B surface antigen (HBsAg) who had either chronic renal failure or a functioning...
Histological evidence of carcinoma in a hepatic tumour associated with oral contraceptives.
Davis, M, Portmann, B, Searle, M, Wright, R, Williams, R
A primary hepatic tumour occurred in a 21-year-old woman who had been taking oral contraceptives for two years; she was treated by partial hepatectomy. Part of the neoplasm showed features suggestive...
Fulminant hepatic failure resulting from coexistent Wilson's disease and hepatitis E.
Sallie, R, Chiyende, J, Tan, K C, Bradley, D, Portmann, B, Williams, R, ...
Fulminant hepatic failure resulting from hepatitis E and coexistent Wilson's disease was diagnosed in a six year old girl six weeks after returning from a holiday in India. Wilson's disease was...
Primary amyloidosis and severe intrahepatic cholestatic jaundice.
Peters, R A, Koukoulis, G, Gimson, A, Portmann, B, Westaby, D, Williams, R
Liver involvement in systemic amyloidosis is frequent but is rarely of clinical importance. Five patients with severe cholestatic jaundice are described and an additional 20 from published reports...
Uddin, W, Ramage, J K, Portmann, B, Wilson, P, Benjamin, I, Tan, K C, ...
Polycystic liver disease is commonly asymptomatic but may present with hepatomegaly, abdominal distension, and dull abdominal pain. Transudative ascites is a rare manifestation in these patients but...
p53 Protein overexpression in cholangiocarcinoma arising in primary sclerosing cholangitis.
Rizzi, P M, Ryder, S D, Portmann, B, Ramage, J K, Naoumov, N V, Williams, R
The protein encoded by the p53 tumour suppressor gene plays an important part in the regulation of cell growth. Abnormalities of this gene represent one of the most common genetic changes in the...
Acute liver damage and ecstasy ingestion.
Ellis, A J, Wendon, J A, Portmann, B, Williams, R
Eight cases of ecstasy related acute liver damage referred to a specialised liver unit are described. Two patients presented after collapse within six hours of ecstasy ingestion with hyperthermia,...
Portmann, B, Galbraith, R M, Eddleston, A L, Zuckerman, A J, Williams, R
A modified immunofluorescent technique was used for the detection of HBSAg in formalin-fixed liver tissue, thereby allowing retrospective examination of paraffin sections and avoiding the need to...
Focal nodular hyperplasia of the liver: a rational approach to treatment.
Mowat, A P, Gutjahr, P, Portmann, B, Dawson, J L, Williams, R
Focal nodular hyperplasia of the liver in a 3 year old child has been successfully treated by ligation of the hepatic artery branches supplying the lesion. The prominence of the abnormal vasculature...
Cochrane, A M, Moussouros, A, Smith, A, Portmann, B, Eddleston, A L, Williams, R
A study of lymphocyte cytotoxicity for rabbit hepatocyte cultures in 15 patients with untreated chronic active hepatitis showed positive results in all cases, both HBsAg positive and negative. After...
Johnson, P J, Krasner, N, Portmann, B, Eddleston, A L, Williams, R
An analysis of 294 patients who died with cirrhosis showed that 24% had developed hepatocellular carcinoma. Haemochromatosis and HBsAg positive chronic active hepatitis were high risk groups (36% and...
Hepatocellular carcinoma in primary biliary cirrhosis: report of four cases.
Krasner, N, Johnson, P J, Portmann, B, Watkinson, G, Macsween, R N, Williams, R
Of 98 patients dying with primary biliary cirrhosis only four developed hepatocellular carcinoma. It is suggested that the development of hepatocellular carcinoma is uncommon in this type of chronic...
Hepatitis from dantrolene sodium.
Wilkinson, S P, Portmann, B, Williams, R
The clinical course and histological changes in the liver during a presumed adverse reaction to the drug dantrolene sodium are described in four patients. After a typical prodrome one developed a...
Hepatocellular carcinoma in HBsAg-negative chronic active hepatitis.
Jenkins, P J, Melia, W M, Portmann, B, Longworth Krafft, J M, Williams, R
The occurrence of hepatocellular carcinoma in HBsAg-negative chronic active hepatitis is described in two patients. signs of the tumour appeared 18 years and nine years after the first clinical signs...
Autoimmunity to a liver membrane lipoprotein and liver damage in alcoholic liver disease.
Perperas, A, Tsantoulas, D, Portmann, B, Eddleston, A L, Williams, R
Antibodies reacting with a liver membrane lipoprotein (LSP) have been detected by radioimmunoassay in the sera of 15 (27%) of 55 patients with alcohol-related liver lesions. There was a close...
Lymphocyte cytotoxicity to autologous hepatocytes in HBsAg positive chronic liver disease.
Mieli-Vergani, G, Vergani, D, Portmann, B, White, Y, Murray-Lyon, I, Marigold, J H, ...
Lymphocytes from 39 patients with HBsAg positive chronic liver disease were incubated with their own hepatocytes to investigate mechanisms of lymphocyte-mediated liver damage. Cytotoxicity was...
Antibodies to a human liver membrane lipoprotein (LSP) in primary biliary cirrhosis.
Tsantoulas, D, Perperas, A, Portmann, B, Eddleston, A L, Williams, R
Antibodies reacting with a human liver-specific membrane lipoprotein (LSP) have been detected using a sensitive and specific radioimmunoassay in 19 (51%) of 37 patients with primary biliary...
Wilson's disease and hepatocellular carcinoma: possible protective role of copper.
Wilkinson, M L, Portmann, B, Williams, R
A male patient with Wilson's disease developed a hepatocellular carcinoma after treatment for nine years with D-penicillamine. Examination at necropsy showed that excess liver copper had been...
Antibodies to alcohol altered liver cell determinants in patients with alcoholic liver disease.
Neuberger, J, Crossley, I R, Saunders, J B, Davis, M, Portmann, B, Eddleston, A L, ...
Circulating antibodies reacting specifically with hepatocytes isolated from ethanol pretreated rabbits have been demonstrated by two techniques - induced cytotoxicity and immunofluorescence. In the...
Double blind controlled trial of d-penicillamine in patients with primary biliary cirrhosis.
Neuberger, J, Christensen, E, Portmann, B, Caballeria, J, Rodes, J, Ranek, L, ...
One hundred and eighty nine patients with primary biliary cirrhosis were entered into a double blind, placebo controlled randomised trial starting in January 1978 to assess the therapeutic value of...
Hepatic sarcomas in adults: a review of 25 cases.
Forbes, A, Portmann, B, Johnson, P, Williams, R
Twenty-five patients with an apparently primary sarcoma of the liver are reviewed. Presenting complaints were non-specific, but hepatomegaly and abnormal liver function tests were usual. Use of the...
Mohsen, A H, Easterbrook, P J, Taylor, C, Portmann, B, Kulasegaram, R, Murad, S, ...
Objectives: To compare the rate of hepatic fibrosis progression in hepatitis C virus (HCV) infected and human immunodeficiency virus (HIV)-HCV coinfected patients, and to identify factors that may...
Lymphocyte cytotoxicity to autologous hepatocytes in HBsAg-negative chronic active hepatitis.
Vergani, G M, Vergani, D, Jenkins, P J, Portmann, B, Mowat, A P, Eddleston, A L, ...
In a micrototoxicity assay, lymphocytes from ten out of sixteen patients with HBsAg-negative chronic active hepatitis have been shown to be cytotoxic to autologous hepatocytes isolated from...
Cellular immune responses to salivary antigens in autoimmune liver disease with sicca syndrome.
McFarlane, I G, Wojcicka, B M, Tsantoulas, D C, Funk, C, Portmann, B, Eddleston, A L, ...
Twenty-six patients with primary biliary cirrhosis (PBC) and twenty-two with active chronic hepatitis (ACH) were examined for evidence of the sicca syndrome (keratoconjunctivitis sicca, xerostomia)....
Nouri-Aria, K T, Alexander, G J, Portmann, B, Vergani, D, Eddleston, A L, Williams, R
To investigate the relationship between liver damage and immune regulation in hepatitis B virus (HBV) infection, 68 patients with HBsAg in serum and a spectrum of liver damage have been studied and...
Preferential activation of helper/inducer T lymphocytes in autoimmune chronic active hepatitis.
Lobo-Yeo, A, Alviggi, L, Mieli-Vergani, G, Portmann, B, Mowat, A P, Vergani, D
We found a significant increase of activated circulating T lymphocytes expressing interleukin 2 receptor (IL-2r) (mean +/- s.e.m. 11.0 +/- 1.1%) or DR antigen (5.0 +/- 0.49%) in patients with...
Emergency liver transplantation after Kasai portoenterostomy.
Corbally, M T, Heaton, N, Rela, M, Mieli-Vergani, G, Portmann, B, Mowat, A, ...
Three patients with stable liver function after Kasai portoenterostomy developed acute liver failure secondary to liver necrosis. Doppler ultrasound at presentation revealed reversed diastolic...
Glycogenosis type IV: liver transplant at 12 years.
Dhawan, A, Tan, K C, Portmann, B, Mowat, A P
Hepatomegaly, the presenting feature of type IV glycogen storage disease at 20 months of age, regressed during childhood. The patient remained asymptomatic until 12 years of age when, after an...
Fulminant hepatic failure in childhood: An analysis of 31 cases
Psacharopoulos, H T, Mowat, Alex P, Davies, M, Portmann, B, Silk, D B A, Williams, Roger
To document the clinical features and complications of fulminant hepatic failure in childhood, 31 consecutive cases (of whom only 9 survived) were reviewed. Of 26 children with acute hepatitis...
Extrahepatic biliary atresia: preoperative assessment and surgical results in 47 consecutive cases.
Psacharopoulos, H T, Howard, E R, Portmann, B, Mowat, A P
Of 47 consecutive infants with extrahepatic biliary atresia, effective bile drainage with the return of the serum bilirubin concentration to normal, was achieved in 17 (38%). Direct bile duct-to-bowl...
The prelaparotomy diagnosis of extrahepatic biliary atresia.
Manolaki, A G, Larcher, V F, Mowat, A P, Barrett, J J, Portmann, B, Howard, E R
The diagnostic accuracy of laboratory investigations in the prelaparotomy differentiation between extrahepatic biliary atresia (EHBA) and intrahepatic disease (IHD) was assessed in 86 consecutive...
Psacharopoulos, H T, Mowat, A P, Cook, P J, Carlile, P A, Portmann, B, Rodeck, C H
We reviewed the hepatic features in 136 children with alpha 1 antitrypsin deficiency (PiZ). Eighty two were studied prospectively, 74 of whom had chronic liver disease. Sixty seven children with...
Duration of chronic active hepatitis and the development of cirrhosis.
Vegnente, A, Larcher, V F, Mowat, A P, Portmann, B, Williams, R
Chronic hepatitis implies that clinical and biochemical features of hepatitis have been present for at least 6 months; but irreversible liver damage may occur with subclinical disease suggesting that...
Liver transplant for giant cell hepatitis with autoimmune haemolytic anaemia
Melendez, H. V., Rela, M., Baker, A., Ball, C., Portmann, B., Mieli-Vergani, G., ...
Acute liver failure induced by carbamazepine.
Hadzić, N, Portmann, B, Davies, E T, Mowat, A P, Mieli-Vergani, G
Two children developed acute liver failure while taking carbamazepine. Clinical and laboratory findings suggested an immunoallergic reaction, but only one child improved on steroids. Determination of...
Endoscopic retrograde cholangiopancreatography in infantile cholestasis.
Wilkinson, M L, Mieli-Vergani, G, Ball, C, Portmann, B, Mowat, A P
The difficulty of distinguishing surgically correctable causes of conjugated hyperbilirubinaemia in infants from other causes means that some infants may undergo laparotomy and intraoperative...
Senaldi, G, Portmann, B, Mowat, A P, Mieli-Vergani, G, Vergani, D
The portal tract mononuclear cell infiltrate has been characterised in 28 liver biopsy samples showing features of chronic aggressive hepatitis from 12 patients with autoimmune chronic active...
Rela, M., Heaton, N. D., Vougas, V., Rolando, N., Wade, J., Portmann, B., ...
Fungal infections following liver transplantation are not uncommon and may be life-threatening. Superficial candidal infections of the bronchus, oesophagus and urinary tract are the most common mode...
Myocarditis and fulminant hepatic failure from coxsackievirus B infection.
Read, R. B., Ede, R. J., Morgan-Capner, P., Moscoso, G., Portmann, B., Williams, R.
A case of fulminant hepatic failure in association with myocarditis is reported. Presentation suggested an acute hepatitis which was complicated by cardiac failure. Evidence of severe myocarditis was...
A fatal case of Epstein-Barr virus infection with jaundice and renal failure.
Davies, M. H., Morgan-Capner, P., Portmann, B., Wilkinson, S. P., Williams, R.
A fatal case of Epstein-Barr virus infection in a 17-year-old male is described. The patient presented with an illness clinically typical of infectious mononucleosis but death followed development of...
Fulminant hepatic failure in non-Hodgkin's lymphoma
Braude, S., Portmann, B., Gimson, A. E. S., Williams, Roger
Two patients with fulminant hepatic failure presenting during the course of non-Hodgkin's lymphoma are described. One patient had no previous history of lymphoma whereas in the other a small bowel...
Pathogenesis of renal failure in cirrhosis and fulminant hepatic failure
Wilkinson, S. P., Hurst, D., Portmann, B., Williams, Roger
Acute renal failure in cirrhosis and fulminant hepatic failure represents a spectrum with ‘functional renal failure’ at one end and acute tubular necrosis at the other. In fulminant hepatic...
Relationship between serum alpha-foetoprotein, cirrhosis and survival in hepatocellular carcinoma.
Johnson, P. J., Melia, W. M., Palmer, M. K., Portmann, B., Williams, R.
An analysis of survival time of 57 West European patients with hepatocellular carcinoma was carried out to define which of several possible factors (age, sex, cirrhosis and raised serum...