B. Wojciak-Stothard

The ADMA/DDAH pathway is a critical regulator of endothelial cell motility (2007)

Wojciak-Stothard, B., Torondel, B., Tsang, L.Y.F., Fleming, I., Fisslthaler, B., Leiper, J.M., ...

Asymmetric dimethylarginine (ADMA) is an inhibitor of nitric oxide production associated with abnormal blood vessel growth and repair, however, the mechanism of action of ADMA is not well understood....

Disruption of methylarginine metabolism impairs vascular homeostasis (2007)

Leiper, J., Nandi, M., Torondel, B., Murray-Rust, J., Malaki, M., O'Hara, B., ...

Asymmetric dimethylarginine (ADMA) and monomethyl arginine (L-NMMA) are endogenously produced amino acids that inhibit all three isoforms of nitric oxide synthase (NOS)1. ADMA accumulates in various...

Disruption of methylarginine metabolism impairs vascular homeostasis. (2007)

Leiper, J., Nandi, M., Torondel, B., Murray-Rust, J., Malaki, M., O'Hara, B., ...

Asymmetric dimethylarginine (ADMA) and monomethyl arginine (L-NMMA) are endogenously produced amino acids that inhibit all three isoforms of nitric oxide synthase (NOS). ADMA accumulates in various...

Regulation of endothelial barrier function during flow-induced conversion to an arterial phenotype (2007)

Seebach, J., Donnert, G., Kronstein, R., Werth, S., Wojciak-Stothard, B., Falzarano, D., ...

Rac1 and RhoA as regulators of endothelial phenotype and barrier function in hypoxia-induced neonatal pulmonary hypertension (2006)

Wojciak-Stothard, B., Tsang, L.Y.F., Paleolog, E., Hall, S.M., Haworth, S.G.

Hypoxia is a common cause of persistant pulmonary hypertension in the newborn (PPHN), a condition associated with endothelial dysfunction and abnormal pulmonary vascular remodeling. The GTPase RhoA...

Shear stress-induced endothelial cell polarization is mediated by Rho and Rac but not Cdc42 or PI 3-kinases (2003)

Wojciak-Stothard, B., Ridley, A.J.

Shear stress induces endothelial polarization and migration in the direction of flow accompanied by extensive remodeling of the actin cytoskeleton. The GTPases RhoA, Rac1, and Cdc42 are known to...

9Rgr; and Rac but not Cdc42 regulate endothelial cell permeability (2001)

Wojciak-Stothard, B., Potempa, S., Eichholtz, T., Ridley, A.J.

Endothelial permeability induced by thrombin and histamine is accompanied by actin stress fibre assembly and intercellular gap formation. Here, we investigate the roles of the &Rgr; family GTPases...