B. Zbar

Publication List Details

Period

1989 - 1997

Number

207

Co-Authors

Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas (1997)

Schmidt, L, Duh, FM, Chen, F, Kishida, T, Glenn, G, Choke, P, ...

Hereditary papillary renal carcinoma (HPRC) is a recently recognized form of inherited kidney cancer characterized by a predisposition to develop multiple, bilateral papillary renal tumours. The...

Gene structure of the human MET proto-oncogene (1997)

Duh, F-M, Scherer, SW, Tsui, L-C, Lerman, M, Zbar, B, Schmidt, L

By direct sequencing of cosmids using primers designed from the known cDNA sequence, we identified 19 exons in the human MET proto-oncogene, and sequenced the corresponding 5' and 3' exon-intron...

Genetic linkage between Von Hippel--Lindau disease and three microsatellite polymorphisms refines the localisation of the VHL locus (1993)

Crossey, P.A., Maher, E.R., Jones, M.H., Richards, F.M., Latif, F., Phipps, M.E., ...

Von Hippel—Lindau (VHL) disease is a dominantly inherited familial cancer syndrome characterised by the development of retinal and central nervous system haemangioblastomas, renal cell carcinoma...

Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma.

Herman, J G, Latif, F, Weng, Y, Lerman, M I, Zbar, B, Liu, S, ...

Mutational inactivation and allelic loss of the von Hippel-Lindau (VHL) gene appear to be causal events for the majority of spontaneous clear-cell renal carcinomas. We now show that hypermethylation...

Distinct hypermethylation patterns occur at altered chromosome loci in human lung and colon cancer.

Makos, M, Nelkin, B D, Lerman, M I, Latif, F, Zbar, B, Baylin, S B

Regional increases in DNA methylation occur in normally unmethylated cytosine-rich areas in neoplastic cells. These changes could potentially alter chromatin structure to inactivate gene...

Mosaicism in von Hippel–Lindau Disease: Lessons from Kindreds with Germline Mutations Identified in Offspring with Mosaic Parents

Sgambati, M. T., Stolle, C., Choyke, P. L., Walther, M. M., Zbar, B., Linehan, W. M., ...

von Hippel-Lindau disease (VHL [MIM 193300]) is a heritable autosomal dominant multiple-neoplastic disorder with high penetrance. It is characterized by brain and spinal-cord hemangioblastomas,...

Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma.

Herman, J G, Latif, F, Weng, Y, Lerman, M I, Zbar, B, Liu, S, ...

Mutational inactivation and allelic loss of the von Hippel-Lindau (VHL) gene appear to be causal events for the majority of spontaneous clear-cell renal carcinomas. We now show that hypermethylation...

Distinct hypermethylation patterns occur at altered chromosome loci in human lung and colon cancer.

Makos, M, Nelkin, B D, Lerman, M I, Latif, F, Zbar, B, Baylin, S B

Regional increases in DNA methylation occur in normally unmethylated cytosine-rich areas in neoplastic cells. These changes could potentially alter chromatin structure to inactivate gene...

Mosaicism in von Hippel–Lindau Disease: Lessons from Kindreds with Germline Mutations Identified in Offspring with Mosaic Parents

Sgambati, M. T., Stolle, C., Choyke, P. L., Walther, M. M., Zbar, B., Linehan, W. M., ...

von Hippel-Lindau disease (VHL [MIM 193300]) is a heritable autosomal dominant multiple-neoplastic disorder with high penetrance. It is characterized by brain and spinal-cord hemangioblastomas,...

Expression of the Von Hippel-Lindau tumor suppressor gene, VHL, in human fetal kidney and during mouse embryogenesis.

Kessler, P. M., Vasavada, S. P., Rackley, R. R., Stackhouse, T., Duh, F. M., Latif, F., ...

BACKGROUND: Von Hippel-Lindau (VHL) disease is a familial cancer syndrome that has a dominant inherited pattern which predisposes affected individuals to a variety of tumours. The most frequent...

Genotype-phenotype correlation in von Hippel-Lindau disease: identification of a mutation associated with VHL type 2A.

Chen, F, Slife, L, Kishida, T, Mulvihill, J, Tisherman, S E, Zbar, B

A family with von Hippel-Lindau disease (VHL) type 2A has been shown to have a T to C missense mutation at nucleotide 547 of the VHL gene. This gives further support for the proposal to associate the...

Detection of germline mutations in the von Hippel-Lindau disease gene by the primer specified restriction map modification method.

Kishida, T, Chen, F, Lerman, M I, Zbar, B

Von Hippel-Lindau disease (VHL) is an inherited disorder characterised by a predisposition to develop tumours in the eyes, central nervous system, kidneys, and adrenal glands. Recently the VHL gene...