Connective tissue mast cells exhibit time-dependent degranulation heterogeneity.
Kaminer, M S, Murphy, G F, Zweiman, B, Lavker, R M
Previous studies have identified two ultrastructurally distinct forms of mast cell (MC) degranulation following activation. Immunoglobulin E (IgE)-mediated reactions are characterized by a very rapid...
Tanus, T, Atkins, P C, Zweiman, B
We found increased serum histamine-releasing activity (HRA) in 27% of patients with chronic idiopathic urticaria. Patterns of clinical manifestations were similar in those with and without serum HRA,...
An unusual presentation of Sjögren's syndrome.
A 44-year-old woman presented with a long history of nausea and vomiting and was found to have hypokalemic metabolic acidosis with elevation of the urine bicarbonate level consistent with the new...
We report an interesting association of inflammatory myopathy, characterized pathologically as dermatomyositis, with bronchiolitis obliterans/organizing pneumonia and anti-histidyl-tRNA synthetase...
Schwartz, L B, Sakai, K, Bradford, T R, Ren, S, Zweiman, B, Worobec, A S, ...
Tryptase, a protease produced by all mast cells, was evaluated as a clinical marker of systemic mastocytosis. Two sandwich immunoassays were evaluated, one which used the mAb G5 for capture, the...
Levinson, A I, Dziarski, A, Zweiman, B, Dziarski, R
Staphylococcal cell wall products have been widely examined as probes for dissection of in vitro human immune responses. Mitogenic and polyclonal B-cell-activating properties have been attributed to...
Decline in delayed-type hypersensitivity response in obese women following weight reduction.
Stallone, D D, Stunkard, A J, Zweiman, B, Wadden, T A, Foster, G D
The effect of weight loss on immuno function was evaluated in 14 middle-aged obese women. Cutaneous delayed-type hypersensitivity to five recall antigens was measured before a weight loss of 21 kg...
Accumulation of leukotriene C4 and histamine in human allergic skin reactions.
Talbot, S F, Atkins, P C, Goetzl, E J, Zweiman, B
To determine whether lipoxygenase products of arachidonic acid metabolism are released in vivo during human allergic cutaneous reactions, we serially assayed chamber fluid placed over denuded skin...
Connective tissue mast cells exhibit time-dependent degranulation heterogeneity.
Kaminer, M S, Murphy, G F, Zweiman, B, Lavker, R M
Previous studies have identified two ultrastructurally distinct forms of mast cell (MC) degranulation following activation. Immunoglobulin E (IgE)-mediated reactions are characterized by a very rapid...
Tanus, T, Atkins, P C, Zweiman, B
We found increased serum histamine-releasing activity (HRA) in 27% of patients with chronic idiopathic urticaria. Patterns of clinical manifestations were similar in those with and without serum HRA,...
An unusual presentation of Sjögren's syndrome.
A 44-year-old woman presented with a long history of nausea and vomiting and was found to have hypokalemic metabolic acidosis with elevation of the urine bicarbonate level consistent with the new...
We report an interesting association of inflammatory myopathy, characterized pathologically as dermatomyositis, with bronchiolitis obliterans/organizing pneumonia and anti-histidyl-tRNA synthetase...
Schwartz, L B, Sakai, K, Bradford, T R, Ren, S, Zweiman, B, Worobec, A S, ...
Tryptase, a protease produced by all mast cells, was evaluated as a clinical marker of systemic mastocytosis. Two sandwich immunoassays were evaluated, one which used the mAb G5 for capture, the...
Levinson, A I, Dziarski, A, Zweiman, B, Dziarski, R
Staphylococcal cell wall products have been widely examined as probes for dissection of in vitro human immune responses. Mitogenic and polyclonal B-cell-activating properties have been attributed to...
Decline in delayed-type hypersensitivity response in obese women following weight reduction.
Stallone, D D, Stunkard, A J, Zweiman, B, Wadden, T A, Foster, G D
The effect of weight loss on immuno function was evaluated in 14 middle-aged obese women. Cutaneous delayed-type hypersensitivity to five recall antigens was measured before a weight loss of 21 kg...
Accumulation of leukotriene C4 and histamine in human allergic skin reactions.
Talbot, S F, Atkins, P C, Goetzl, E J, Zweiman, B
To determine whether lipoxygenase products of arachidonic acid metabolism are released in vivo during human allergic cutaneous reactions, we serially assayed chamber fluid placed over denuded skin...
Reactive and non-reactive lymphocytes in experimental allergic encephalomyelitis.
Levinson, A I, Lisak, R P, Zweiman, B, Wilkerson, L D
Myelin basic protein (BP),induces an increased in vitro proliferative response of peritoneal exudate cells (PEC), compared with that given by pheripheral blood lymphocytes (PBL), in guinea-pigs with...
The immunohistology of the thymus in myasthenia gravis.
Kornstein, M. J., Brooks, J. J., Anderson, A. O., Levinson, A. I., Lisak, R. P., Zweiman, B.
We have investigated cell subpopulations in frozen sections of thymus tissue obtained from myasthenic (MG) and control subjects. With the use of an avidin-biotin immunoperoxidase system with...
Cerebrospinal fluid lymphocytes in experimental allergic encephalomyelitis.
Wilkerson, L D, Lisak, R P, Zweiman, B
We report characteristics of the cerebrospinal fluid (CSF) pleocytosis (616+/-148 cells/microliter) that occurred in guinea-pigs with definite clinical experimental allergic encephalomyelitis...
T and B lymphocytes in multiple sclerosis.
Lisak, R P, Levinson, A I, Zweiman, B, Abdou, N I
The percentage and total number of E and EAC rosettes, as indicators of T and B lymphocytes respectively, were studied in the blood of subjects with multiple sclerosis (MS) and normals. MS patients...
A new approach to the autoradiographic study of proliferating lymphocytes.
An adaptation of a cell filtration method for the autoradiographic study of cultured lymphocytes has been developed. The percentages of labelled cells are very similar in the filtered cell population...
Effects of azathioprine therapy on bone marrow-dependent and thymus-dependent cells in man
Abdou, N. I., Zweiman, B., Casella, S. R.
The in vitro immunologic parameters of both bone marrow-dependent (B) and thymus-dependent (T) cells of patients with no demonstrable immunologic abnormality and to whom only azathioprine (az) was...
Cold reactive antilymphocyte antibodies in neurological diseases.
Lisak, R P, Mercado, F, Zweiman, B
Cold reactive (15 degrees C) antilymphocyte antibodies were detected in the sera of 33% of patients with multiple sclerosis, 50% with Guillain-Barré syndrome, 42% with myasthenia gravis, and 38%...
We have compared the lymphocyte in vitro proliferative response induced by muscle extract, phytohaemagglutinin, and pokeweed mitogen in peripheral blood lymphocytes of patients with myasthenia...
Serum immunogloblin levels in myasthenia gravis, polymyositis, and dermatomyositis.
Analyses of serum immunoglobulin (Ig) levels were performed in patients with myasthenia gravis, polymyositis and dermatomyositis, and in normal subjects. The mean IgG levels were elevated in the...
Antimyelin antibody in multiple sclerosis: no change during immunosuppression
Wilkerson, L. D., Lisak, R. P., Zweiman, B., Silberberg, D. H.
We studied retrospectively levels of antimyelin antibody in a group of 13 multiple sclerosis patients who underwent a clinical trial of long-term, high dose (2.0-4.5 mg/kg/day) azathiaprine therapy....