Babatunde A. Ogunnaike

A hybrid multiscale Monte Carlo algorithm (HyMSMC) to cope with disparity in time scales and species populations in intracellular networks (2007)

Samant, Asawari, Ogunnaike, Babatunde A, Vlachos, Dionisios G

Abstract Background The fundamental role that intrinsic stochasticity plays in cellular functions has been shown via numerous computational and experimental studies. In the face of such evidence, it...

Quantifying gene network connectivity in silico: Scalability and accuracy of a modular approach (2006)

Yalamanchili, Nirupama, Zak, Daniel E., Ogunnaike, Babatunde A., Schwaber, James S., Kriete, Andres, Kholodenko, Boris N.

Large, complex data sets that are generated from microarray experiments, create a need for systematic analysis techniques to unravel the underlying connectivity of gene regulatory networks. A modular...

Systems analysis of circadian time-dependent neuronal epidermal growth factor receptor signaling (2006)

Zak, Daniel E, Hao, Haiping, Vadigepalli, Rajanikanth, Miller, Gregory M, Ogunnaike, Babatunde A, Schwaber, James S

Abstract Background Identifying the gene regulatory networks governing physiological signal integration remains an important challenge in circadian biology. Epidermal growth factor receptor (EGFR)...

Systems analysis of circadian time-dependent neuronal epidermal growth factor receptor signaling (2006)

Zak, Daniel E., Hao, Haiping, Vadigepalli, Rajanikanth, Miller, Gregory M., Ogunnaike, Babatunde A., Schwaber, James S.

Background Identifying the gene regulatory networks governing physiological signal integration remains an important challenge in circadian biology. Epidermal growth factor receptor (EGFR) has been...

Systems analysis of circadian time-dependent neuronal epidermal growth factor receptor signaling (2006)

Zak, Daniel E., Hao, Haiping, Vadigepalli, Rajanikanth, Miller, Gregory M., Ogunnaike, Babatunde A., Schwaber, James S.

Background Identifying the gene regulatory networks governing physiological signal integration remains an important challenge in circadian biology. Epidermal growth factor receptor (EGFR) has been...

Designing experiments that aid in the identification of regulatory networks (2006)

Kauffman, Kenneth J., Ogunnaike, Babatunde A., Edwards, Jeremy S.

Predictive mathematical models of the interactions of a genetic network can provide insight into the mechanisms of gene regulation, the role of various genes within a network and how multiple genes...

Designing experiments that aid in the identification of regulatory networks (2006)

Kauffman, Kenneth J., Ogunnaike, Babatunde A., Edwards, Jeremy S.

Predictive mathematical models of the interactions of a genetic network can provide insight into the mechanisms of gene regulation, the role of various genes within a network and how multiple genes...

Process Dynamics, Modeling, and Control (1994)

Ogunnaike, Babatunde A. (Babatunde Ayodeji)

Contenido: Introducción a los conceptos del control de procesos y a la implementación de sistemas de control; Procesos dinámicos; Modelado de procesos e identificación; Control simple de un...

Systems analysis of circadian time-dependent neuronal epidermal growth factor receptor signaling

Zak, Daniel E, Hao, Haiping, Vadigepalli, Rajanikanth, Miller, Gregory M, Ogunnaike, Babatunde A, Schwaber, James S

A systems level analysis of circadian time-dependent signaling via the epidermal growth factor receptor in the suprachiasmatic nucleus suggests several transcription factors that mediate the...

Modeling the VPAC2-Activated cAMP/PKA Signaling Pathway: From Receptor to Circadian Clock Gene Induction

Hao, Haiping, Zak, Daniel E., Sauter, Thomas, Schwaber, James, Ogunnaike, Babatunde A.

Increasing evidence suggests an important role for VPAC2-activated signal transduction pathways in maintaining a synchronized biological clock in the suprachiasmatic nucleus (SCN). Activation of the...

Ligand-dependent responses of the ErbB signaling network: experimental and modeling analyses

Birtwistle, Marc R, Hatakeyama, Mariko, Yumoto, Noriko, Ogunnaike, Babatunde A, Hoek, Jan B, Kholodenko, Boris N

Deregulation of ErbB signaling plays a key role in the progression of multiple human cancers. To help understand ErbB signaling quantitatively, in this work we combine traditional experiments with...

Elucidating the digital control mechanism for DNA damage repair with the p53–Mdm2 system: single cell data analysis and ensemble modelling

Ogunnaike, Babatunde A

Recent experimental evidence about DNA damage response using the p53–Mdm2 system has raised some fundamental questions about the control mechanism employed. In response to DNA damage, an ensemble...