Urbani, Simona, Amadei, Barbara, Tola, Daniela, Massari, Marco, Schivazappa, Simona, Missale, Gabriele, ...
Hepatitis C virus (HCV)-specific CD8 cell exhaustion may represent a mechanism of HCV persistence. The inhibitory receptor PD-1 has been reported to be up-regulated in exhausted CD8 cells. Therefore,...
Characterization of Hepatitis B Virus (HBV)-Specific T-Cell Dysfunction in Chronic HBV Infection▿
Boni, Carolina, Fisicaro, Paola, Valdatta, Caterina, Amadei, Barbara, Di Vincenzo, Paola, Giuberti, Tiziana, ...
Dysfunctional CD8+ T cells present in chronic virus infections can express programmed death 1 (PD-1) molecules, and the inhibition of the engagement of PD-1 with its ligand (PD-L1) has been reported...
Heterologous T cell immunity in severe hepatitis C virus infection
Urbani, Simona, Amadei, Barbara, Fisicaro, Paola, Pilli, Massimo, Missale, Gabriele, Bertoletti, Antonio, ...
Hepatitis C virus (HCV) can cause liver disease of variable severity. Expansion of preexisting memory CD8 T cells by cross-reactivity with a new heterologous virus infection has been shown in mice to...