Nitric Oxide deficiency promotes vascular side effects of cyclooxygenase inhibitors. (2006)
Anning, Peter Brian, Coles, Barbara, Morton, Jonathan, Wang, Haibin, Uddin, Jashim, Morrow, Jason D., ...
The cardiovascular safety of COX-2 selective and nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) has recently been called into question. The factors that predispose to adverse events by...
In vivo aspirin supplementation inhibits nitric oxide consumption by human platelets (2005)
Williams, Paula Claire, Coffey, Marcus Jonathan, Coles, Barbara, Sanchez, Stephanie, Morrow, Jason D., Cockcroft, John Ronald, ...
In vivo aspirin supplementation inhibits nitric oxide consumption by human platelets (2005)
Williams, Paula Claire, Coffey, Marcus Jonathan, Coles, Barbara, Sanchez, Stephanie, Morrow, Jason D., Cockcroft, John Ronald, ...
Antiplatelet therapies improve endothelial function in atherosclerosis, suggesting that platelets regulate vascular nitric oxide (NO) bioactivity in vivo. Herein, washed platelets consumed NO on...
Coffey, Marcus Jonathan, Coles, Barbara, Locke, Matthew, Bermudez-Fajardo, Alexandra, Williams, Paula Claire, Jarvis, Gavin E., ...
Recent studies implicate the collagen receptor, glycoprotein VI (GPVI) in activation of platelet 12-lipoxygenase (p12-LOX). Herein, we show that GPVI-stimulated 12-hydro(peroxy)eicosatetraenoic acid...
Coffey, Marcus Jonathan, Jarvis, Gavin E, Gibbins, Jonathan M., Coles, Barbara, Barrett, Natasha E., Wylie, Oliver R.E., ...
Lipoxygenases (LOX) contribute to vascular disease and inflammation through generation of bioactive lipids, including 12-hydro(pero)xyeicosatetraenoic acid (12-H(P)ETE). The physiological mechanisms...
Coffey, Marcus Jonathan, Jarvis, Gavin E, Gibbins, Jonathan M., Coles, Barbara, Barrett, Natasha E., Wylie, Oliver R.E., ...
Lipoxygenases (LOX) contribute to vascular disease and inflammation through generation of bioactive lipids, including 12-hydro(pero)xyeicosatetraenoic acid (12-H(P)ETE). The physiological mechanisms...
Coles, Barbara, Bloodsworth, Allison, Clark, Stephen Robert, Lewis, Malcolm John, Cross, Andrew R., Freeman, Bruce A., ...
Nitration of unsaturated fatty acids such as linoleate by NO-derived reactive species forms novel derivatives (including nitrolinoleate [LNO2]) that can stimulate smooth muscle relaxation and block...
Coles, Barbara, Bloodsworth, Allison, Clark, Stephen Robert, Lewis, Malcolm John, Cross, Andrew R., Freeman, Bruce A., ...
Nitration of unsaturated fatty acids such as linoleate by NO-derived reactive species forms novel derivatives (including nitrolinoleate [LNO2]) that can stimulate smooth muscle relaxation and block...
Coles, Barbara, Bloodsworth, Allison, Clark, Stephen Robert, Lewis, Malcolm John, Cross, Andrew R., Freeman, Bruce A., ...
Nitration of unsaturated fatty acids such as linoleate by NO-derived reactive species forms novel derivatives (including nitrolinoleate [LNO2]) that can stimulate smooth muscle relaxation and block...
Coles, Barbara, Bloodsworth, Allison, Clark, Stephen Robert, Lewis, Malcolm John, Cross, Andrew R., Freeman, Bruce A., ...
Nitration of unsaturated fatty acids such as linoleate by NO-derived reactive species forms novel derivatives (including nitrolinoleate [LNO2]) that can stimulate smooth muscle relaxation and block...
Coffey, Marcus Jonathan, Natarajan, Rama, Chumley, Philip H., Coles, Barbara, Thimmalapura, Pushpa-Rekha, Nowell, Mari Ann, ...
Coffey, Marcus Jonathan, Natarajan, Rama, Chumley, Philip H., Coles, Barbara, Thimmalapura, Pushpa-Rekha, Nowell, Mari Ann, ...
12/15-Lipoxygenase (LOX) activity is elevated in vascular diseases associated with impaired nitric oxide (( small middle dot)NO) bioactivity, such as hypertension and atherosclerosis. In this study,...
The KATP and Kv channels are distinct entities: a reply to Edwards and Weston (1994)
Ashcroft, Frances M, Coles, Barbara, Kenna, Susan, Proks, Peter, Röper, Jochen, Reid, John, ...
Coffey, Marcus J., Natarajan, Rama, Chumley, Phillip H., Coles, Barbara, Thimmalapura, Pushpa-Rekha, Nowell, Mari, ...
12/15-Lipoxygenase (LOX) activity is elevated in vascular diseases associated with impaired nitric oxide (⋅NO) bioactivity, such as hypertension and atherosclerosis. In this study, primary porcine...
Coffey, Marcus J., Natarajan, Rama, Chumley, Phillip H., Coles, Barbara, Thimmalapura, Pushpa-Rekha, Nowell, Mari, ...
12/15-Lipoxygenase (LOX) activity is elevated in vascular diseases associated with impaired nitric oxide (⋅NO) bioactivity, such as hypertension and atherosclerosis. In this study, primary porcine...
Anning, Peter B., Coles, Barbara, Bermudez-Fajardo, Alexandra, Martin, Patricia E.M., Levison, Bruce S., Hazen, Stanley L., ...
12/15-Lipoxygenase (12/15-LOX) plays a pathogenic role in atherosclerosis. To characterize whether 12/15-LOX also contributes to endothelial dysfunction and hypertension, regulation of vessel tone...
Nitric oxide deficiency promotes vascular side effects of cyclooxygenase inhibitors
Anning, Peter B., Coles, Barbara, Morton, Jonathan, Wang, Haibin, Uddin, Jashim, Morrow, Jason D., ...
The cardiovascular safety of COX-2 selective and nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) has recently been called into question. The factors that predispose to adverse events by...
Coles, Barbara, Fielding, Ceri A., Rose-John, Stefan, Scheller, Jürgen, Jones, Simon A., O’Donnell, Valerie B.
Interleukin (IL)-6 acts via a receptor complex consisting of the cognate IL-6 receptor (IL-6R) or the soluble IL-6 receptor (sIL-6R) and glycoprotein 130 (gp130). Here, we investigated the role of...
CD59 or C3 are not requred for angiotensin II-dependent hypertension or hypertrophy in mice
Coles, Barbara, Lewis, Ruth, Anning, Peter B, Morton, Jonathan, Baalasubramanian, Sivasankar, Morgan, B Paul, ...
Complement is a major pro-inflammatory innate immune system whose serum activity correlates with systolic blood pressure in humans. To date, no studies using in vivo models have directly examined the...
Morton, Jonathan, Coles, Barbara, Wright, Kate, Gallimore, Awen, Morrow, Jason D., Terry, Erin S., ...
Whether leukocytes exert an influence on vascular function in vivo is not known. Here, genetic and pharmacologic approaches show that the absence of neutrophils leads to acute blood pressure...