Integrated analysis of breast cancer cell lines reveals unique signaling pathways (2009)
Heiser, Laura M, Wang, Nicholas J, Talcott, Carolyn L, Laderoute, Keith R, Knapp, Merrill, Guan, Yinghui, ...
Abstract Background Cancer is a heterogeneous disease resulting from the accumulation of genetic defects that negatively impact control of cell division, motility, adhesion and apoptosis....
Göran Jönsson, Tara L. Naylor, Johan Vallon-christersson, Johan Staaf, Jia Huang, M. Renee Ward, ...
Mutations in BRCA1 and BRCA2 account for a significant proportion of hereditary breast cancers. Earlier studies have shown that inherited and sporadic tumors progress along different somatic genetic...
Patterns of somatic mutation in human cancer genomes (2007)
Greenman, Christopher, Stephens, Philip, Smith, Raffaella, Dalgliesh, Gillian L., Hunter, Christopher, Bignell, Graham, ...
Cancers arise owing to mutations in a subset of genes that confer growth advantage. The availability of the human genome sequence led us to propose that systematic resequencing of cancer genomes for...
A Genome wide linkage search for breast cancer susceptibility genes (2006)
Smith, Paula, McGuffog, Lesley, Easton, Douglas F., Mann, Graham J., Pupo, Gulietta M., Newman, Beth M., ...
Mutations in known breast cancer susceptibility genes account for a minority of the familial aggregation of the disease. To search for further breast cancer susceptibility genes, we performed a...
A Genome wide linkage search for breast cancer susceptibility genes (2006)
Smith, Paula, McGuffog, Lesley, Easton, Douglas F., Mann, Graham J., Pupo, Gulietta M., Newman, Beth M., ...
Mutations in known breast cancer susceptibility genes account for a minority of the familial aggregation of the disease. To search for further breast cancer susceptibility genes, we performed a...
A Genome wide linkage search for breast cancer susceptibility genes (2006)
Smith, Paula, McGuffog, Lesley, Easton, Douglas F., Mann, Graham J., Pupo, Gulietta M., Newman, Beth M., ...
Mutations in known breast cancer susceptibility genes account for a minority of the familial aggregation of the disease. To search for further breast cancer susceptibility genes, we performed a...
A Genome wide linkage search for breast cancer susceptibility genes (2006)
Smith, Paula, McGuffog, Lesley, Easton, Douglas F., Mann, Graham J., Pupo, Gulietta M., Newman, Beth M., ...
Mutations in known breast cancer susceptibility genes account for a minority of the familial aggregation of the disease. To search for further breast cancer susceptibility genes, we performed a...
Diskin, Sharon J., Eck, Thomas, Greshock, Joel, Mosse, Yael P., Naylor, Tara, Stoeckert, Christian J., ...
Regions of gain and loss of genomic DNA occur in many cancers and can drive the genesis and progression of disease. These copy number aberrations (CNAs) can be detected at high resolution by using...
The joint effect of smoking and AIB1 on breast cancer risk in BRCA1 mutation carriers (2006)
Colilla, Susan, Kantoff, Philip W., Neuhausen, Susan L., Godwin, Andrew K., Daly, Mary B., Narod, Steven A., ...
Women with BRCA1 mutations are at an elevated risk for breast cancer. AIB1 (NCOA3/SRC3) genotype and smoking may alter this risk. We examined the differences in breast cancer risk by AIB1...
Genome-wide linkage screen for testicular germ cell tumour susceptibility loci (2006)
Crockford, Gillian P., Linger, Rachel, Hockley, Sarah, Dudakia, Darshna, Johnson, Lola, Huddart, Robert, ...
A family history of disease is a strong risk factor for testicular germ cell tumour (TGCT). In order to identify the location of putative TGCT susceptibility gene(s) we conducted a linkage search in...
Diskin, Sharon J., Eck, Thomas, Greshock, Joel, Mosse, Yael P., Naylor, Tara, Stoeckert, Christian J., ...
Regions of gain and loss of genomic DNA occur in many cancers and can drive the genesis and progression of disease. These copy number aberrations (CNAs) can be detected at high resolution by using...
Genome-wide linkage screen for testicular germ cell tumour susceptibility loci (2006)
Crockford, Gillian P., Linger, Rachel, Hockley, Sarah, Dudakia, Darshna, Johnson, Lola, Huddart, Robert, ...
A family history of disease is a strong risk factor for testicular germ cell tumour (TGCT). In order to identify the location of putative TGCT susceptibility gene(s) we conducted a linkage search in...
A Genome wide linkage search for breast cancer susceptibility genes (2006)
Smith, Paula, McGuffog, Lesley, Easton, Douglas F., Mann, Graham J., Pupo, Gulietta M., Newman, Beth M., ...
Mutations in known breast cancer susceptibility genes account for a minority of the familial aggregation of the disease. To search for further breast cancer susceptibility genes, we performed a...
Margolin, Adam A., Greshock, Joel, Naylor, Tara L., Mosse, Yael, Maris, John M., Bignell, Graham, ...
Summary: This synopsis provides an overview of array-based comparative genomic hybridization data display, abstraction and analysis using CGHAnalyzer, a software suite, designed specifically for this...
The joint effect of smoking and AIB1 on breast cancer risk in BRCA1 mutation carriers (2005)
Colilla, Susan, Kantoff, Philip W., Neuhausen, Susan L., Godwin, Andrew K., Daly, Mary B., Narod, Steven A., ...
Women with BRCA1 mutations are at an elevated risk for breast cancer. AIB1 (NCOA3/SRC3) genotype and smoking may alter this risk. We examined the differences in breast cancer risk by AIB1...
Margolin, Adam A., Greshock, Joel, Naylor, Tara L., Mosse, Yael, Maris, John M., Bignell, Graham, ...
Summary: This synopsis provides an overview of array-based comparative genomic hybridization (aCGH) data display, abstraction and analysis using CGHAnalyzer, a software suite, designed specifically...
Greshock, Joel, Naylor, Tara L., Margolin, Adam, Diskin, Sharon, Cleaver, Stephen H., Futreal, P. Andrew, ...
Array-based comparative genomic hybridization (aCGH) is a recently developed tool for genome-wide determination of DNA copy number alterations. This technology has tremendous potential for...
Greshock, Joel, Naylor, Tara L., Margolin, Adam, Diskin, Sharon, Cleaver, Stephen H., Futreal, P. Andrew, ...
Array-based comparative genomic hybridization (aCGH) is a recently developed tool for genome-wide determination of DNA copy number alterations. This technology has tremendous potential for...
CGH-targeted linkage analysis reveals a possible BRCA1 modifier locus on chromosome 5q (2002)
Nathanson, Katherine L., Shugart, Yin Y., Omaruddin, Romaica, Szabo, Csilla, Goldgar, David, Rebbeck, Timothy R., ...
Women with germline mutations in BRCA1 have a greatly elevated risk of breast and ovarian cancer. However, considerable variation in the degree of breast cancer risk associated with a BRCA1 mutation...
Cancer Risk Estimates for BRCA1 Mutation Carriers Identified in a Risk Evaluation Program (2002)
Brose, Marcia S., Rebbeck, Timothy R., Calzone, Kathleen A., Stopfer, Jill E., Nathanson, Katherine L., Weber, Barbara L.
Background: Increasing numbers of BRCA1 mutation carriers are being identified in cancer risk evaluation programs. However, no estimates of cancer risk specific to a clinic-based population of...
'Other' breast cancer susceptibility genes: searching for more holy grail (2001)
Nathanson, Katherine L., Weber, Barbara L.
While germline mutations in BRCA1 and BRCA2 account for most, if not all families with autosomal dominant transmission of susceptibility to both breast and ovarian cancer, it has become clear that...
Genetic and Hormonal Risk Factors in Breast Cancer (2000)
Martin, Anne-Marie, Weber, Barbara L.
Breast cancer poses a serious public health problem, and it is hoped that identification of genetic and environmental factors that contribute to the development of breast cancer will enhance...
Breast Cancer Risk After Bilateral Prophylactic Oophorectomy in BRCA1 Mutation Carriers (1999)
Rebbeck, Timothy R., Levin, Albert M., Eisen, Andrea, Snyder, Carrie, Watson, Patrice, Cannon-Albright, Lisa, ...
BACKGROUND: The availability of genetic testing for inherited mutations in the BRCA1 gene provides potentially valuable information to women at high risk of breast or ovarian cancer; however,...
Chen, Junjie, Silver, Daniel P., Walpita, Deepika, Cantor, Sharon B., Gazdar, Adi F., Tomlinson, Gail, ...
BRCA1 and BRCA2 account for most cases of familial, early onset breast and/or ovarian cancer and encode products that each interact with hRAD51. Results presented here show that BRCA1 and BRCA2...
Chromosomal mapping of the rat Slc4a family of anion exchanger genes, Ae1, Ae2, and Ae3 (1996)
Tissil, F., Couch, Fergus J., Szpirer, Josiane, Szpirer, C., Van Vooren, P., Simon, J.S., ...
Peer Reviewed
Microdissection and microcloning of chromosomal alterations in human breast cancer (1995)
Collins, Francis S., Diamond, Austin, Guan, X. Y., Trent, Jeffrey M., Weber, Barbara L., Zhang, Ji, ...
The recognition of recurring sites of chromosome changes in malignancies has greatly facilitated the identification of genes implicated in the pathogenesis of human cancers. Based especially upon...
Transcript identification in the BRCA1 candidate region (1995)
Abel, Kenneth J., Couch, Fergus J., Merajver, Sofia D., Castilla, Lucio H., Brody, Lawrence C., Collins, Francis S., ...
Chromosome 17q12-21 is known to contain a gene (or genes) which confers susceptibility to early-onset breast cancer and ovarian cancer (BRCA1). Identification and isolation of BRCA1 will likely...
Abel, Kenneth J., Xu, Junzhe, Yin, Gui-Ying, Lyons, Robert H., Meisler, Miriam H., Weber, Barbara L.
The human gene BRCA1, conferring susceptibility to early-onset breast and ovarian cancer, has recently been isolated. Here we describe isolation of cDNAs, sequence analysis, and genomic localization...
Couch, Fergus J., Kiousis, Sam, Castilla, Lucio H., Xu, Junzhe, Chandrasekharappa, Settara C., Chamberlain, Jeffrey S., ...
A familial early onset breast cancer gene (BRCA1) has been localized to chromosome 17q21. To aid in the identification of this gene a number of new microsatellite markers from the D17S857 to D17S78...
Couch, Fergus J., Abel, Kenneth J., Brody, Lawrence C., Boehnke, Michael, Collins, Francis S., Weber, Barbara L.
The gene encoding ATP-citrate lyase, designated ACLY, was mapped to human chromosome 17q12-q21 by PCR on a panel of human/rodent somatic cell hybrids and localized to 17q21.1 by PCH on a panel of...
Chandrasekharappa, Settara C., Friedman, Lori, King, Stephanie E., Lee, Yoon-Hee, Welsch, Piri, Bowcock, Anne M., ...
Peer Reviewed
Flejter, Wendy L., Barcroft, Christine L., Guo, Sun-Wei, Lynch, Eric D., Boehnke, Michael, Chandrasekharappa, Settara C., ...
A gene designated BRCA1, implicated in the susceptibility to early-onset familial breast cancer, has recently been localized to chromosome 17q12-q21. To date, the order of DNA markers mapped within...
A Radiation Hybrid Map of the BRCA1 Region of Chromosome 17q12-q21 (1993)
Abel, Kenneth J., Boehnke, Michael, Prahalad, Murali, Ho, Peggy P., Flejter, Wendy L., Watkins, Melanie, ...
The chromosomal region 17q12-q21 contains a gene (BRCA1) conferring susceptibility to early-onset familial breast and ovarian cancer. An 8000-rad radiation-reduced hybrid (RH) panel was constructed...
Selection criteria for breast cancer chemoprevention subjects (1993)
Ruffin, Mack T., August, David A., Kelloff, Gary J., Boone, Charles W., Weber, Barbara L., Brenner, Dean E.
Early phase chemoprevention trials differ from standard therapeutic clinical trials because asymptomatic, healthy people are treated with a potentially toxic intervention for a prolonged period of...
Integrated analysis of breast cancer cell lines reveals unique signaling pathways
Heiser, Laura M, Wang, Nicholas J, Talcott, Carolyn L, Laderoute, Keith R, Knapp, Merrill, Guan, Yinghui, ...
Mapping of sub-networks in the EGFR-MAPK pathway in different breast cancer cell lines reveals that PAK1 may be a marker for sensitivity to MEK inhibitors.