Immunpathogenese der Hepatitis B und C / (1998)
Hannover, Med. Hochsch., Habil.-Schr., 1998.
He, Xiao-Song, Rehermann, Barbara, López-Labrador, F. Xavier, Boisvert, Judie, Cheung, Ramsey, Mumm, John, ...
It is believed that the hepatitis C virus (HCV)-specific CD8+ cytotoxic T lymphocytes (CTLs) play a role in the development of liver cell injury and in the clearance of the virus. To develop a direct...
Wedemeyer, Heiner, Mizukoshi, Eishiro, Davis, Anthony R., Bennink, Jack R., Rehermann, Barbara
The cellular immune response contributes to viral clearance as well as to liver injury in acute and chronic hepatitis C virus (HCV) infection. An immunodominant determinant frequently recognized by...
Satoi, Jujin, Murata, Kazumoto, Lechmann, Martin, Manickan, Elanchezhiyan, Zhang, Zhensheng, Wedemeyer, Heiner, ...
To study the effect of genetic immunization on transgenic expression of hepatitis C virus (HCV) proteins, we evaluated the immunological response of HCV transgenic mice to HCV expression plasmids....
Mizukoshi, Eishiro, Nascimbeni, Michelina, Blaustein, Joshua B., Mihalik, Kathleen, Rice, Charles M., Liang, T. Jake, ...
The chimpanzee is a critical animal model for studying cellular immune responses to infectious pathogens such as hepatitis B and C viruses, human immunodeficiency virus, and malaria. Several...
Major, Marian E., Mihalik, Kathleen, Puig, Montserrat, Rehermann, Barbara, Nascimbeni, Michelina, Rice, Charles M., ...
Responses in three chimpanzees were compared following challenge with a clonal hepatitis C virus (HCV) contained in plasma from an animal that had received infectious RNA transcripts. Two of the...
Thomson, Michael, Nascimbeni, Michelina, Havert, Michael B., Major, Marian, Gonzales, Sophia, Alter, Harvey, ...
Clearance of hepatitis C virus (HCV) infection in humans and chimpanzees is thought to be associated with the induction of strong T-cell responses. We studied four chimpanzees infected with HCV...
Nascimbeni, Michelina, Mizukoshi, Eishiro, Bosmann, Markus, Major, Marian E., Mihalik, Kathleen, Rice, Charles M., ...
The immunological correlates of hepatitis C virus (HCV)-specific immunity are not well understood. Antibodies to HCV structural proteins do not appear to play a key role in clearance of the virus and...
Jeong, Sook-Hyang, Qiao, Ming, Nascimbeni, Michelina, Hu, Zongyi, Rehermann, Barbara, Murthy, Krishna, ...
We have previously reported the production of hepatitis C virus-like particles (HCV-LP) using a recombinant baculovirus containing the cDNA of the HCV structural proteins (core, E1, and E2). These...
Hepatitis C virus mutation affects proteasomal epitope processing
Seifert, Ulrike, Liermann, Heike, Racanelli, Vito, Halenius, Anne, Wiese, Manfred, Wedemeyer, Heiner, ...
The high incidence of hepatitis C virus (HCV) persistence raises the question of how HCV interferes with host immune responses. Studying a single-source HCV outbreak, we identified an HCV mutation...
Liver-Directed Gamma Interferon Gene Delivery in Chronic Hepatitis C
Shin, Eui-Cheol, Protzer, Ulrike, Untergasser, Andreas, Feinstone, Stephen M., Rice, Charles M., Hasselschwert, Dana, ...
Gamma interferon (IFN-γ) has been shown to inhibit replication of subgenomic and genomic hepatitis C virus (HCV) RNAs in vitro and to noncytolytically suppress hepatitis B virus (HBV) replication in...
Virus-induced type I IFN stimulates generation of immunoproteasomes at the site of infection
Shin, Eui-Cheol, Seifert, Ulrike, Kato, Takanobu, Rice, Charles M., Feinstone, Stephen M., Kloetzel, Peter-M., ...
IFN-γ is known as the initial and primary inducer of immunoproteasomes during viral infections. We now report that type I IFN induced the transcription and translation of immunoproteasome subunits,...
He, Xiao-Song, Rehermann, Barbara, López-Labrador, F. Xavier, Boisvert, Judie, Cheung, Ramsey, Mumm, John, ...
It is believed that the hepatitis C virus (HCV)-specific CD8+ cytotoxic T lymphocytes (CTLs) play a role in the development of liver cell injury and in the clearance of the virus. To develop a direct...
Wedemeyer, Heiner, Mizukoshi, Eishiro, Davis, Anthony R., Bennink, Jack R., Rehermann, Barbara
The cellular immune response contributes to viral clearance as well as to liver injury in acute and chronic hepatitis C virus (HCV) infection. An immunodominant determinant frequently recognized by...
Satoi, Jujin, Murata, Kazumoto, Lechmann, Martin, Manickan, Elanchezhiyan, Zhang, Zhensheng, Wedemeyer, Heiner, ...
To study the effect of genetic immunization on transgenic expression of hepatitis C virus (HCV) proteins, we evaluated the immunological response of HCV transgenic mice to HCV expression plasmids....
Mizukoshi, Eishiro, Nascimbeni, Michelina, Blaustein, Joshua B., Mihalik, Kathleen, Rice, Charles M., Liang, T. Jake, ...
The chimpanzee is a critical animal model for studying cellular immune responses to infectious pathogens such as hepatitis B and C viruses, human immunodeficiency virus, and malaria. Several...
Major, Marian E., Mihalik, Kathleen, Puig, Montserrat, Rehermann, Barbara, Nascimbeni, Michelina, Rice, Charles M., ...
Responses in three chimpanzees were compared following challenge with a clonal hepatitis C virus (HCV) contained in plasma from an animal that had received infectious RNA transcripts. Two of the...
Thomson, Michael, Nascimbeni, Michelina, Havert, Michael B., Major, Marian, Gonzales, Sophia, Alter, Harvey, ...
Clearance of hepatitis C virus (HCV) infection in humans and chimpanzees is thought to be associated with the induction of strong T-cell responses. We studied four chimpanzees infected with HCV...
Nascimbeni, Michelina, Mizukoshi, Eishiro, Bosmann, Markus, Major, Marian E., Mihalik, Kathleen, Rice, Charles M., ...
The immunological correlates of hepatitis C virus (HCV)-specific immunity are not well understood. Antibodies to HCV structural proteins do not appear to play a key role in clearance of the virus and...
Jeong, Sook-Hyang, Qiao, Ming, Nascimbeni, Michelina, Hu, Zongyi, Rehermann, Barbara, Murthy, Krishna, ...
We have previously reported the production of hepatitis C virus-like particles (HCV-LP) using a recombinant baculovirus containing the cDNA of the HCV structural proteins (core, E1, and E2). These...
Hepatitis C virus mutation affects proteasomal epitope processing
Seifert, Ulrike, Liermann, Heike, Racanelli, Vito, Halenius, Anne, Wiese, Manfred, Wedemeyer, Heiner, ...
The high incidence of hepatitis C virus (HCV) persistence raises the question of how HCV interferes with host immune responses. Studying a single-source HCV outbreak, we identified an HCV mutation...
Liver-Directed Gamma Interferon Gene Delivery in Chronic Hepatitis C
Shin, Eui-Cheol, Protzer, Ulrike, Untergasser, Andreas, Feinstone, Stephen M., Rice, Charles M., Hasselschwert, Dana, ...
Gamma interferon (IFN-γ) has been shown to inhibit replication of subgenomic and genomic hepatitis C virus (HCV) RNAs in vitro and to noncytolytically suppress hepatitis B virus (HBV) replication in...
Virus-induced type I IFN stimulates generation of immunoproteasomes at the site of infection
Shin, Eui-Cheol, Seifert, Ulrike, Kato, Takanobu, Rice, Charles M., Feinstone, Stephen M., Kloetzel, Peter-M., ...
IFN-γ is known as the initial and primary inducer of immunoproteasomes during viral infections. We now report that type I IFN induced the transcription and translation of immunoproteasome subunits,...
Manigold, Tobias, Shin, Eui-Cheol, Mizukoshi, Eishiro, Mihalik, Kathleen, Murthy, Krishna K., Rice, Charles M., ...
Hepatitis C virus (HCV) poses a global health problem because it readily establishes persistent infection and a vaccine is not available. CD4+CD25+ T cells have been implicated in HCV persistence...
Ahlenstiel, Golo, Martin, Maureen P., Gao, Xiaojiang, Carrington, Mary, Rehermann, Barbara
Genetic studies suggest a role for killer cell immunoglobulin-like receptor/HLA (KIR/HLA) compound genotypes in the outcome of viral infections, but functional data to explain these epidemiological...
Private aspects of heterologous immunity
Rehermann, Barbara, Shin, Eui-Cheol
Clinical manifestations of viral infections are highly variable, both in type and severity, among individual patients. Differences in host genetics and in dose and route of infection contribute to...
Ruppert, Thomas, Rehermann, Barbara, Schmidt, Marion, Koszinowski, Ulrich, Kloetzel, Peter-M.
Interferon (IFN)-γ–induced cells express the proteasome subunits low molecular weight protein (LMP)2, LMP7, and MECL-1 (multicatalytic endopeptidase complex–like 1), leading to the formation of...
Shin, Eui-Cheol, Capone, Stefania, Cortese, Riccardo, Colloca, Stefano, Nicosia, Alfredo, Folgori, Antonella, ...
Peripheral blood T-cell responses are used as biomarkers in hepatitis C virus (HCV) vaccine trials. However, it is not clear how T-cell responses in the blood correlate with those in the liver, the...