Substituent effects on the genotoxicity of 4-nitrostilbene derivatives (1994)
Hooberman, Barry H., Brezzell, M. D., Das, S. K., You, Zhengqing, Sinsheimer, Joseph E.
4-Nitrostilbene and twelve of its derivatives (eleven E-stilbenes and two Z-stilbenes) were examined for possible quantitative structure-activity relationships of their in vitro and in vivo...
You, Zhengqing, Brezzell, M. D., Das, S. K., Hooberman, Barry H., Sinsheimer, Joseph E.
4-Amino-4'-substituted biphenyls and 4-aminostilbenes substituted in the 3' or 4' position were studied for their in vitro and in vivo genotoxicity. The in vitro mutagenicity of the biphenyls with...
Das, L., Das, S. K., Hooberman, Barry H., Chu, Ernest H. Y., Sinsheimer, Joseph E.
Mouse lymphocytes were exposed in vitro for 2 h or in vivo for 24 h to benzidine and related aromatic amines to test for chromosome aberrations (CA) and mitotic indices. Uninduced mouse S9 was used...
ortho-Substituent effects on the in vitro and in vivo genotoxicity of benzidine derivatives (1993)
You, Zhengqing, Brezzell, M. D., Das, S. K., Espadas-Torre, M. C., Hooberman, Barry H., Sinsheimer, Joseph E.
Benzidine and its 3,3'-diamino, 3,3'-dimethyl, 3,3'-dimethoxy, 3,3'-difluoro, 3,3'-dichloro, 3,3'-dibromo, 3,3'-dicarbomethoxy and 3,3'-dinitro derivatives together with 2-nitrobenzidine and...
Hooberman, Barry H., Chakraborty, Pulak K., Sinsheimer, Joseph E.
A quantitative structure-activity relationship approach was used to investigate the mutagenicity of a series of seventeen-monosubstituted propylene oxides in Salmonella typhimurium strains TA100 and...
The genotoxicity of enantiomeric aliphatic epoxides (1993)
Sinsheimer, Joseph E., Chen, R., Das, S. K., Hooberman, Barry H., Osorio, S., You, Zhengqing
The (R)- and (S)-optical isomers of 9 epoxides, benzyloxymethyloxirane, epichlorohydrin, glycidol, glycidyl 3-nitrobenzenesulfonate, glycidyl 4-nitrobenzoate, glycidyl tosylate, styrene oxide,...
Sinsheimer, Joseph E., Hooberman, Barry H., Das, S. K., Brezzell, M. D., You, Zhengqing
Benzidine and 12 related aromatic amines have been studied for the effects of substituent groups and [pi] orbital conjugation on their genotoxicity as measured by their mutagenicity in vitro with...
DNA strand breaks in liver for four aliphatic epoxides in mice (1990)
Giri, A. K., Messerly, E. A., Chakraborty, Pulak K., Hooberman, Barry H., Sinsheimer, Joseph E.
Four aliphatic epoxides, 1-naphthyl glycidyl ether (NGE), 1-naphthylpropylene oxide (NPO), 4-nitrophenyl glycidyl ether (NPGE), 3,3,3-trichloropropylene oxide (TCPO) and two of their precursors,...
Detoxication of aliphatic epoxides by diol formation and glutathione conjugation (1987)
Sinsheimer, Joseph E., Van Den Eeckhout, E., Hooberman, Barry H., Beylin, Vladimir G.
The Ames procedure with Salmonella typhimurium strain TA100 was used to follow the detoxication by rat liver fractions of two series of aliphatic epoxides. The epoxides employed were 3-chloro-,...
Mutagenicity of para-substituted [alpha]-methylstyrene oxide derivatives with Salmonella (1986)
Rosman, L. B., Beylin, Vladimir G., Gaddamidi, V., Hooberman, Barry H., Sinsheimer, Joseph E.
A series of 5 para-substituted [alpha]-methylstyrene oxide derivatives have been synthesized and together with [alpha]-methylstyrene oxide as well as styrene oxide have been studied as to their...
Substituent effects on the mutagenicity of phenyl glycidyl ethers in Salmonella typhimurium (1982)
Neau, Steven H., Hooberman, Barry H., Frantz, Stephen W., Sinsheimer, Joseph E.
Phenyl glycidyl ether and 6 para-substituted derivatives, the methoxy, tert-butyl, methyl, chloro, bromo and nitro compounds, were tested in the Ames' test for mutagenicity. With the exception of the...