Technical note : Flow cytometric identification of bovine milk neutrophils and simultaneous quantification of their viability (2009)
Piepers, Sofie,
De Vliegher, Sarne,
Demeyere, Kristel,
Lambrecht, Bart,
De Kruif, Aart,
Meyer, Evelyne,
...
The aim of the present study was to develop a flow cytometrical procedure for the quantification of the proportion of viable, apoptotic and necrotic polymorphonuclear neutrophilic leukocytes (PMN)...
Sensitization by intratracheally injected dendritic cells is independent of antigen presentation by host antigen-presenting cells (2009)
Kuipers, Harmjan,
Soullie, Thomas,
Hammad, Hamida,
Willart, Monique,
Kool, Mirjam,
Hijdra, Danielle,
...
Adoptive transfer of antigen-pulsed dendritic cells ( DC) in the airways of mice has been used as a model system for eosinophilic airway inflammation, which allows studying the DC-specific...
The danger within: endogenous danger signals, atopy and asthma (2009)
Willart, Monique,
Lambrecht, Bart
Abstract: In allergic asthmatics, airway inflammation is triggered by specific (inhalation of allergen such as house dust mite allergen and pollen spores) or non-specific triggers (such as air...
Immune Suppression Feature of Ursodeoxycholic Acid is DC-mediated as Measured in Eosinophilic Airway Inflammation Model (2009)
Kleinjan, A.,
Willart, Monique,
Hammad, Hamida,
Van Nimwegen, M.,
Moons, L.,
Hoogsteden, H.C.,
...
Chronic airway inflammation promotes de novo sensitization to inhaled allergen by persistent activation of dendritic cells (2009)
Van Rijt, LS,
Vos, N,
Willart, Monique,
Muskens, F,
Hoogsteden, H,
Lambrecht, Bart
Protein tyrosine phosphatases regulate asthma development in a murine asthma model (2009)
Pouliot, Philippe,
Camateros, Pierre,
Radzioch, Danuta,
Lambrecht, Bart,
Olivier, Martin
Allergic asthma is a chronic inflammatory disease characterized by Th2-type inflammation. Although the cellular interactions are now well studied, the intracellular signaling involved in asthma...
The influence of oxygen concentration and inflation pressure during ischemia on lung ischemia reperfusion injury (2009)
Van Der Kaaij, NP,
Kluin, J,
Lachmann, RA,
Den Bakker, MA,
Haitsma, JJ,
Lambrecht, Bart,
...
Surfactant pretreatment decreases long-term damage after ischemia-reperfusion injury of the lung (2009)
Van Der Kaaij, Niels,
Kluin, Jolanda,
Haitsma, Jack,
Den Bakker, Michael,
Lambrecht, Bart,
Lachmann, Burkhard,
...
Objective: Lung ischemia-reperfusion injury (LIRI) is a risk factor for primary acute graft failure following lung transplantation. LIRI hereby contributes to morbidity and mortality after lung...
Mechanism of action of clinically approved adjuvants (2009)
Lambrecht, Bart,
Kool, Mirjam,
Willart, Monique,
Hammad, Hamida
Aluminum-containing adjuvants continue to be the most widely used adjuvants for human use. In the last year a major breakthrough has been the realization that alum adjuvant triggers an ancient...
Cyclooxygenase-2 mucosal Dc mediates induction of regulatory T cells in the intestine through suppression of IL-4 (2009)
Broere, F.,
Du Pré, M.F.,
Van Berkel, L.A.,
Garssen, J.,
Schmid-Weber, C.B.,
Lambrecht, Bart,
...
Oral intake of protein leads to tolerance through the induction of regulatory T cells (Tr cells) in mesenteric lymph nodes (MLNs). Here we show that the inhibition of cyclooxygenase-2 (COX-2) in vivo...
House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells (2009)
Hammad, Hamida,
Chieppa, Marcello,
Perros, Frédèric,
Willart, Monique,
Germain, Ronald,
Lambrecht, Bart
Barrier epithelial cells and airway dendritic cells (DCs) make up the first line of defense against inhaled substances such as house dust mite (HDM) allergen and endotoxin (lipopolysaccharide, LPS)....
Blockade of CCR4 in a humanized model of asthma reveals a critical role for DC-derived CCL17 and CCL22 in attracting Th2 cells and inducing airway inflammation (2009)
Perros, Frédèric,
Hoogsteden, H.C.,
Coyle, A.J.,
Lambrecht, Bart,
Hammad, Hamida
As Th2 type lymphocytes orchestrate the cardinal features of allergic asthma, inhibiting their recruitment to the lungs could be of therapeutic benefit. Although human Th2 cells express the CCR4...
Altered expression of epithelial junctional proteins in atopic asthma: possible role in inflammation (2008)
DE BOER, WI,
SHARMA, HS,
BAELEMANS, SMI,
HOOGSTEDEN, HC,
Lambrecht, Bart,
BRAUNSTAHL, GJ
Ischemia of the lung causes extensive long-term pulmonary injury: an experimental study (2008)
VAN DER KAAIJ, NP,
KLUIN, J,
HAITSMA, JJ,
DEN BAKKER, MA,
Lambrecht, Bart,
LACHMANN, B,
...
Lung dendritic cells are stimulated by ultrafine particles and play a key role in particle adjuvant activity (2008)
DE HAAR, C,
KOOL, M,
HASSING, I,
BOL, M,
Lambrecht, Bart,
PIETERS, R
Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells (2008)
KOOL, M,
SOULLIE, T,
VAN NIMWEGEN, M,
Willart, Monique,
MUSKENS, F,
JUNG, S,
...
Clearance of influenza virus from the lung depends on migratory langerin(+)CD11b(-) but not plasmacytoid dendritic cells (2008)
GEURTSVANKESSEL, CH,
Willart, Monique,
VAN RIJT, LS,
MUSKENS, F,
KOOL, M,
BAAS, C,
...
Alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome (2008)
KOOL, M,
PETRILLI, V,
DE SMEDT, T,
ROLAZ, A,
Hammad, Hamida,
VAN NIMWEGEN, M,
...
Sustained desensitization to bacterial Toll-like receptor ligands after resolution of respiratory influenza infection (2008)
DIDIERLAURENT, A,
GOULDING, J,
PATEL, S,
SNELGROVE, R,
LOW, L,
BEBIEN, M,
...
Inducible costimulator blockade prolongs airway lumnal patency in a mouse model of obliterative bronchiolitis (2008)
KleinJan, Alex,
Willart, Monique,
Kuipers, Harmjan,
Coyle, Anthony J.,
Hoogsteden, Henk C.,
Lambrecht, Bart
Background. In human lung transplantation, chronic rejection is accompanied by obliterative bronchiolitis (013), a fibrosing inflammatory condition that leads to occlusion of the bronchial lumen and...
Important research questions in allergy and related diseases: nonallergic rhinitis: a GA(2)LEN paper (2008)
Bousquet, J,
Fokkens, W,
Burney, P,
Durham, SR,
Bachert, Claus,
Akdis, CA,
...
Nonallergic rhinitis (NAR) can be defined as a chronic nasal inflammation which is not caused by systemic IgE-dependent mechanisms. It is common and probably affects far more than 200 million people...
Keratinocyte growth factor induces expansion of murine peripheral CD4(+)Foxp3(+) regulatory T CON and increases their thymic output (2007)
BRUINSMA, M,
VAN SOEST, PL,
LEENEN, PJM,
Lambrecht, Bart,
CUPEDO, T,
LOWENBERG, B,
...
Protective effect of Schistosoma mansoni infection on allergic airway inflammation depends on the intensity and chronicity of infection (2007)
SMITS, HH,
Hammad, Hamida,
VAN NIMWEGEN, M,
SOULLIE, T,
Willart, Monique,
LIEVERS, E,
...
Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells (2007)
IDZKO, M,
Hammad, Hamida,
VAN NIMWEGEN, M,
KOOL, M,
Willart, Monique,
MUSKENS, F,
...
Respiratory syncytial virus differentially activates murine myeloid and plasmacytoid dendritic cells (2007)
BOOGAARD, I,
VAN OOSTEN, M,
VAN RIJT, LS,
MUSKENS, F,
KIMMAN, TG,
Lambrecht, Bart,
...
Osteopontin has a crucial role in allergic airway disease through regulation of dendritic cell subsets (2007)
XANTHOU, G,
ALISSAFI, T,
SEMITEKOLOU, M,
SIMOES, DCM,
ECONOMIDOU, E,
GAGA, M,
...
Activation of the D prostanoid 1 receptor suppresses asthma by modulation of lung dendritic cell function and induction of regulatory T cells (2007)
Hammad, Hamida,
KOOL, M,
SOULLIE, T,
NARUMIYA, S,
TROTTEIN, F,
HOOGSTEDEN, HC,
...
Inhaled iloprost suppresses the cardinal features of asthma via inhibition of airway dendritic cell function (2007)
IDZKO, M,
Hammad, Hamida,
VAN NIMWEGEN, M,
KOOL, M,
VOS, N,
HOOGSTEDEN, HC,
...
Cells meeting our immunophenotypic criteria of endothelial cells are large platelets (2007)
STRIJBOS, MH,
KRAAN, J,
DEN BAKKER, MA,
Lambrecht, Bart,
SLEIJFER, S,
GRATAMA, JW
GATA3-driven Th2 responses inhibit TGF-beta 1-induced FOXP3 expression and the formation of regulatory T cells (2007)
MANTEL, PY,
KUIPERS, H,
BOYMAN, O,
RHYNER, C,
OUAKED, N,
RUCKERT, B,
...
Gene expression profiling and gene copy-number changes in malignant mesothelioma cell lines (2007)
ZANAZZI, C,
HERSMUS, R,
VELTMAN, IM,
GILLIS, AJM,
VAN DRUNEN, E,
BEVERLOO, HB,
...
Gatal regulates dendritic-cell development and survival. (2007)
GUTIERREZ, L,
NIKOLIC, T,
VAN DIJK, TB,
Hammad, Hamida,
VOS, N,
WILLART, M,
...
An essential role for dendritic cells in human and experimental allergic rhinitis (2006)
KLEINJAN, A,
Willart, Monique,
VAN RIJT, LS,
BRAUNSTAHL, GJ,
LEMAN, K,
JUNG, S,
...
Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function (2006)
IDZKO, M,
Hammad, Hamida,
VAN NIMWEGEN, M,
KOOL, M,
MULLER, T,
SOULLIE, T,
...
Contribution of the PD-1 ligands/PD-1 signaling pathway to dendritic cell-mediated CD4(+) T cell activation (2006)
KUIPERS, H,
MUSKENS, F,
Willart, Monique,
HIJDRA, D,
VAN ASSEMA, FBJ,
COYLE, AJ,
...
Mesothelioma environment comprises cytokines and T-regulatory cells that suppress immune responses (2006)
HEGMANS, JPJJ,
HEMMES, A,
Hammad, Hamida,
BOON, L,
HOOGSTEDEN, HC,
Lambrecht, Bart
Surfactant pretreatment ameliorates ischemia-reperfusion injury of the lung (2005)
VAN DER KAAIJ, NP,
HAITSMA, JJ,
KLUIN, J,
Lambrecht, Bart,
LACHMANN, B,
DE BRUIN, RWF,
...
In vivo depletion of lung CD11c(+) dendritic cells during allergen challenge abrogates the characteristic features of asthma (2005)
VAN RIJT, LS,
JUNG, S,
KLEINJAN, A,
VOS, N,
Willart, Monique,
DUEZ, C,
...
Proinflammatory bacterial peptidoglycan as a cofactor for the development of central nervous system autoimmune disease (2005)
VISSER, L,
DE HEER, HJ,
BOVEN, LA,
VAN RIEL, D,
VAN MEURS, M,
MELIEF, MJ,
...
Proteomic analysis of exosomes isolated from human malignant pleural effusions (2004)
BARD, MP,
HEGMANS, JP,
HEMMES, A,
LUIDER, TM,
WILLEMSEN, R,
SEVERIJNEN, LAA,
...
Differential capacity of CD8 alpha(+) or CD8 alpha(-) dendritic cell subsets to prime for eosinophilic airway inflammation in the T-helper type 2-prone milieu of the lung (2004)
Hammad, Hamida,
DE VRIES, VC,
MALDONADO-LOPEZ, R,
MOSER, M,
MALISZEWSKI, C,
HOOGSTEDEN, HC,
...
Dendritic cells retrovirally overexpressing IL-12 induce strong Th1 responses to inhaled antigen in the lung but fail to revert established Th2 sensitization (2004)
KUIPERS, H,
HEIRMAN, C,
HIJDRA, D,
MUSKENS, F,
Willart, Monique,
VAN MEIRVENNE, S,
...
Airways infection with virulent Mycobacterium tuberculosis delays the influx of dendritic cells and the expression of costimulatory molecules in mediastinal lymph nodes (2004)
GARCIA-ROMO, GS,
PEDROZA-GONZALEZ, A,
AGUILAR-LEON, D,
OROZCO-ESTEVEZ, H,
Lambrecht, Bart,
ESTRADA-GARCIA, I,
...
In situ analysis of lung antigen-presenting cells during murine pulmonary infection with virulent Mycobacterium tuberculosis (2004)
PEDROZA-GONZALEZ, A,
GARCIA-ROMO, GS,
AGUILAR-LEON, D,
CALDERON-AMADOR, J,
HURTADO-ORTIZ, R,
OROZCO-ESTEVEZ, H,
...
Essential role of dendritic cell CD80/86 costimulation in the induction, but not reactivation, of T(H)2 effector responses in a mouse model of asthma (2004)
VAN RIFT, LS,
VOS, N,
Willart, Monique,
KLEINJAN, A,
COYLE, AJ,
HOOGSTEDEN, HC,
...
Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen (2004)
DE HEER, HJ,
Hammad, Hamida,
SOULLIE, T,
HIJDRA, D,
VOS, N,
Willart, Monique,
...
A rapid flow cytometric method for determining the cellular composition of bronchoalveolar lavage fluid cells in mouse models of asthma (2004)
VAN RIJT, LS,
KUIPERS, H,
VOS, N,
HIJDRA, D,
HOOGSTEDEN, HC,
Lambrecht, Bart
Proteomic analysis of exosomes secreted by human mesothelioma cells (2004)
HEGMANS, JPJJ,
BARD, MPL,
HEMMES, A,
LUIDER, TM,
KLEIJMEER, MJ,
PRINS, JB,
...
Activation of the D prostanoid receptor 1 regulates immune and skin allergic responses (2004)
ANGELI, W,
STAUMONT, D,
CHARBONNIER, AS,
Hammad, Hamida,
GOSSET, P,
PICHAVANT, M,
...
Activation of peroxisome proliferator-activated receptor-gamma in dendritic cells inhibits the development of eosinophilic airway inflammation in a mouse model of asthma (2004)
Hammad, Hamida,
DE HEER, HJ,
SOULLIE, T,
ANGELI, V,
TROTTEIN, F,
HOOGSTEDEN, HC,
...
Activated protein C inhibits bronchial hyperresponsiveness and Th2 cytokine expression in mice (2004)
YUDA, H,
ADACHI, Y,
TAGUCHI, O,
GABAZZA, EC,
HATAJI, O,
FUJIMOTO, H,
...
Prostaglandin D-2 inhibits airway dentritic cell migration and function in steady state conditions by selective activation of the D prostanoid receptor 1 (2003)
Hammad, Hamida,
DE HEER, HJ,
SOULLIE, T,
HOOGSTEDEN, HC,
TROTTEIN, F,
Lambrecht, Bart
Lipopolysaccharide-induced suppression of airway Th2 responses does not require IL-12 production by dendritic cells (2003)
KUIPERS, H,
HIJDRA, D,
DE VRIES, VC,
Hammad, Hamida,
PRINS, JB,
COYLE, AJ,
...
Airway eosinophils accumulate in the mediastinal lymph nodes but lack antigen-presenting potential for naive T cells (2003)
VAN RIJT, LS,
VOS, N,
HIJDRA, D,
DE VRIES, VC,
HOOGSTEDEN, HC,
Lambrecht, Bart
Peroxisome proliferator-activated receptor gamma inhibits the migration of dendritic cells: Consequences for the immune response (2003)
ANGELI, W,
Hammad, Hamida,
STAELS, B,
CAPRON, M,
Lambrecht, Bart,
TROTTEIN, F
Allergen-induced accumulation of airway dendritic cells is supported by an increase in CD31(hi)Ly6C(neg) bone marrow precursors in a mouse model of asthma (2002)
VAN RIJT, LS,
PRINS, JB,
LEENEN, PJM,
THIELEMANS, K,
DE VRIES, VC,
HOOGSTEDEN, HC,
...
Monocyte-derived dendritic cells induce a house dust mite-specific Th2 allergic inflammation in the lung of humanized SCID mice: Involvement of CCR7 (2002)
Hammad, Hamida,
Lambrecht, Bart,
POCHARD, P,
GOSSET, P,
MARQUILLIES, P,
TONNEL, AB,
...
Enforced expression of GATA-3 in transgenic mice inhibits Th1 differentiation and induces the formation of a T1/ST2-expressing Th2-committed T cell compartment in vivo (2001)
NAWIJN, MC,
DINGJAN, GM,
FERREIRA, R,
Lambrecht, Bart,
KARIS, A,
GROSVELD, F,
...
Myeloid dendritic cells induce Th2 responses to inhaled antigen, leading to eosinophilic airway inflammation. (2000)
Lambrecht, Bart,
DE VEERMAN, M,
COYLE, AJ,
GUTIERREZ-RAMOS, JC,
THEILEMANS, K,
Pauwels, Romain
Presence of substance P and neurokinin 1 receptors in human sputum macrophages and U-937 cells. (1999)
Germonpre, Paul,
Bullock, Gillian,
Lambrecht, Bart,
LUYTEN, W,
Joos, Guy,
...
Antigen presenting dendrititic cells produce neurokinins to stimulate T cell proliferation. (1999)
Lambrecht, Bart,
Everaert, Els,
Germonpre, Paul,
Carro-Muino, Ines,
DE VEERMAN, M,
THIELEMANS, K,
...
Endogenously produced substance P contributes to lymphocyte proliferation induced by dendritic cells and direct TCR ligation (1999)
Lambrecht, Bart,
Germonpre, Paul,
Everaert, Els,
Carro-Muino, Ines,
DE VEERMAN, M,
DE FELIPE, C,
...
Real Options And Preemption Under Incomplete Information (1999)
Bart Lambrecht,
William Perraudin,
Jel Nos D
This paper introduces incomplete information and preemption into an equilibrium model of #rms facing real investment decisions. The optimal investment strategy may lie anywhere between the zero-NPV...
AGE-RELATED DIFFERENCES IN PRESENTATION, TREATMENT AND OUTCOME OF ACUTE MYOCARDIAL-INFARCTION. (1994)
Calle, Paul,
Jordaens, Luc,
De Buyzere, Marc,
RUBBENS, L,
Lambrecht, Bart,
Clement, Denis
Signal averaged electrocardiography and echocardiography in athletes and age matched controls : importance of left ventricular hypertrophy. (1993)
Missault, Luc,
Jordaens, Luc,
Lambrecht, Bart,
DEMEESTER, C,
Duprez, Daniel,
Clement, Denis
A Theory of Takeovers and Disinvestment
Bart Lambrecht,
Stewart C. Myers
We present a real-options model of takeovers and disinvestment in declining industries. As product demand declines, a first-best closure level is reached, where overall value is maximized by shutting...
The Dutch housing market: trends, risks, and outlook
Cunha, Ricardo,
Lambrecht, Bart,
Pawlina, Grzegorz
This paper discusses the housing market in the Netherlands. Our study benefits from access to the DNB household survey (formerly known as CentER Savings Survey) and analyzes a panel dataset of 8867...
Mergers and acquisitions as a response to economic change
Lambrecht, Bart
What causes mergers and acquisitions (M&A)? This is an issue that still remains to some extent a puzzle. While we can, of course, come up with a story or motive for each individual merger or takeover...