Critical role for the p110α phosphoinositide-3-OH kinase in growth and metabolic regulation (2006)
Foukas, Lazaros C., Claret, Marc, Pearce, Wayne, Okkenhaug, Klaus, Meek, Stephen, Peskett, Emma, ...
The eight catalytic subunits of the mammalian phosphoinositide-3-OH kinase (PI(3)K) family form the backbone of an evolutionarily conserved signalling pathway; however, the roles of most PI(3)K...
Critical role for the p110α phosphoinositide-3-OH kinase in growth and metabolic regulation (2006)
Foukas, Lazaros C., Claret, Marc, Pearce, Wayne, Okkenhaug, Klaus, Meek, Stephen, Peskett, Emma, ...
The eight catalytic subunits of the mammalian phosphoinositide-3-OH kinase (PI(3)K) family form the backbone of an evolutionarily conserved signalling pathway; however, the roles of most PI(3)K...
Alison M. Condliffe, Keith Davidson, Karen E. Anderson, Chris D. Ellson, Tom Crabbe, Bart Vanhaesebroeck, ...
doi:10.1182/blood-2005-03-0944 Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils
Beyaert, Rudi, Vanhaesebroeck, Bart, Declercq, Wim, VANLINT, J, Vandenabeele, Peter, AGOSTINIS, P, ...
Both TNF receptors are required for TNF-mediated induction of apoptosis in PC60 cells (1995)
Vandenabeele, Peter, Declercq, Wim, Vanhaesebroeck, Bart, Grooten, Johan, Fiers, Walther
Two pathways of tumor necrosis factor signal transduction: In vitro and in vivo implications (1993)
Fiers, Walther, Beyaert, Rudi, Brouckaert, Peter, Cauwels, Anje, Declercq, Wim, De Valck, Dirk, ...
Vanhaesebroeck, Bart, Decoster, Els, VANOSTADE, X, VANBLADEL, S, Lenaerts, Anne, Van Roy, Frans, ...
p110δ, a novel phosphoinositide 3-kinase in leukocytes
Vanhaesebroeck, Bart, Welham, Melanie J., Kotani, Kei, Stein, Rob, Warne, Patricia H., Zvelebil, Markéta J., ...
Phosphoinositide 3-kinases (PI3Ks) are a family of lipid kinases that have been implicated in signal transduction through tyrosine kinase- and heterotrimeric G-protein-linked receptors. We report...
Two distinct phosphoinositide 3-kinases mediate polypeptide growth factor-stimulated PKB activation
Arcaro, Alexandre, Khanzada, Umme K., Vanhaesebroeck, Bart, Tetley, Teresa D., Waterfield, Michael D., Seckl, Michael J.
Eight human isoforms of phosphoinositide 3-kinases (PI3Ks) exist, but their individual functions remain poorly understood. Here, we show that different human small cell lung carcinoma (SCLC) cell...
Kang, Sohye, Denley, Adam, Vanhaesebroeck, Bart, Vogt, Peter K.
Class I phosphoinositide 3-kinase contains four isoforms of the catalytic subunit, p110α, -β, -γ, and -δ. At physiological levels of expression, the wild-type p110α isoform lacks oncogenic...
Cutillas, Pedro R., Khwaja, Asim, Graupera, Mariona, Pearce, Wayne, Gharbi, Severine, Waterfield, Mike, ...
The phosphoinositide 3-kinase (PI3K)/Akt pathway controls a vast array of normal physiological processes and is frequently aberrantly activated in cancer, thus identifying PI3K/Akt-signaling...
p110δ, a novel phosphoinositide 3-kinase in leukocytes
Vanhaesebroeck, Bart, Welham, Melanie J., Kotani, Kei, Stein, Rob, Warne, Patricia H., Zvelebil, Markéta J., ...
Phosphoinositide 3-kinases (PI3Ks) are a family of lipid kinases that have been implicated in signal transduction through tyrosine kinase- and heterotrimeric G-protein-linked receptors. We report...
Two distinct phosphoinositide 3-kinases mediate polypeptide growth factor-stimulated PKB activation
Arcaro, Alexandre, Khanzada, Umme K., Vanhaesebroeck, Bart, Tetley, Teresa D., Waterfield, Michael D., Seckl, Michael J.
Eight human isoforms of phosphoinositide 3-kinases (PI3Ks) exist, but their individual functions remain poorly understood. Here, we show that different human small cell lung carcinoma (SCLC) cell...
Kang, Sohye, Denley, Adam, Vanhaesebroeck, Bart, Vogt, Peter K.
Class I phosphoinositide 3-kinase contains four isoforms of the catalytic subunit, p110α, -β, -γ, and -δ. At physiological levels of expression, the wild-type p110α isoform lacks oncogenic...
Cutillas, Pedro R., Khwaja, Asim, Graupera, Mariona, Pearce, Wayne, Gharbi, Severine, Waterfield, Mike, ...
The phosphoinositide 3-kinase (PI3K)/Akt pathway controls a vast array of normal physiological processes and is frequently aberrantly activated in cancer, thus identifying PI3K/Akt-signaling...
Control of Axonal Growth and Regeneration of Sensory Neurons by the p110δ PI 3-Kinase
Eickholt, Britta J., Ahmed, Aminul I., Davies, Meirion, Papakonstanti, Evangelia A., Pearce, Wayne, Starkey, Michelle L., ...
The expression and function of the 8 distinct catalytic isoforms of PI 3-kinase (PI3K) in the nervous system are unknown. Whereas most PI3Ks have a broad tissue distribution, the tyrosine...
Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers
Geering, Barbara, Cutillas, Pedro R., Nock, Gemma, Gharbi, Severine I., Vanhaesebroeck, Bart
Class IA phosphoinositide 3-kinases (PI3Ks) signal downstream of tyrosine kinases and Ras and control a wide variety of biological responses. In mammals, these heterodimeric PI3Ks consist of a p110...
Decoster, Els, Cornelis, Sigrid, Vanhaesebroeck, Bart, Fiers, Walter
Tumor necrosis factor (TNF) and lymphotoxin (LT) α are structurally and functionally related cytokines. We expressed the TNF and LT-α genes in murine fibrosarcoma L929r2 cells, which can be...
The p110δ isoform of PI 3-kinase negatively controls RhoA and PTEN
Papakonstanti, Evangelia A, Ridley, Anne J, Vanhaesebroeck, Bart
Inactivation of PI 3-kinase (PI3K) signalling is critical for tumour suppression by PTEN. This is thought to be a unidirectional relationship in which PTEN degrades the lipids produced by PI3K, thus...
Guillermet-Guibert, Julie, Bjorklof, Katja, Salpekar, Ashreena, Gonella, Cristiano, Ramadani, Faruk, Bilancio, Antonio, ...
The p110 isoforms of phosphoinositide 3-kinase (PI3K) are acutely regulated by extracellular stimuli. The class IA PI3K catalytic subunits (p110α, p110β, and p110δ) occur in complex with a Src...
Guo, Hailong, Samarakoon, Asanga, Vanhaesebroeck, Bart, Malarkannan, Subramaniam
Phosphatidylinositol 3-kinases (PI3Ks) play a critical role in regulating B cell receptor– and T cell receptor–mediated signaling. However, their role in natural killer (NK) cell development and...