Sun, Yu, Chen, Jie, Rigas, Basil
Chemopreventive agents generate oxidative stress, which culminates in cell death and may be part of a general mechanism of chemoprevention. The redox-responsive cyclooxygenase (COX)-2, overexpressed...
NO-Donating NSAIDs, PPARδ, and Cancer: Does PPARδ Contribute to Colon Carcinogenesis? (2008)
Gerardo G. Mackenzie, Shaheen Rasheed, William Wertheim, Basil Rigas
The chemopreventive NO-donating NSAIDs (NO-NSAIDs; NSAIDs with an NO-releasing moiety) modulate PPARδ and offer the opportunity to revisit the controversial role of PPARδ in...
NO-Donating NSAIDs, PPARδ, and Cancer: Does PPARδ Contribute to Colon Carcinogenesis? (2008)
Gerardo G. Mackenzie, Shaheen Rasheed, William Wertheim, Basil Rigas
The chemopreventive NO-donating NSAIDs (NO-NSAIDs; NSAIDs with an NO-releasing moiety) modulate PPARδ and offer the opportunity to revisit the controversial role of PPARδ in carcinogenesis (several...
Ouyang, Nengtai, Williams, Jennie L., Rigas, Basil
The inhibitory effect of NO-donating aspirin (NO-ASA) on colon cancer has been demonstrated in vivo and in vitro but its mechanism is still obscure. We investigated the effect of NO-ASA on...
Williams, Jennie L., Ji, Ping, Ouyang, Nengtai, Liu, Xiaoping, Rigas, Basil
Nitric oxide-donating aspirin (NO-ASA) is a promising agent for the control of cancer, whose mechanism of action remains unclear. NF-κB is an important signaling molecule in the pathogenesis of...
NO-donating aspirin induces phase II enzymes in vitro and in vivo (2006)
Gao, Jianjun, Kashfi, Khosrow, Liu, Xiaoping, Rigas, Basil
Modulation of drug metabolizing enzymes, leading to facilitated elimination of carcinogens represents a successful strategy for cancer chemoprevention. Nitric oxide-donating aspirin (NO-ASA) is a...
Ouyang, Nengtai, Williams, Jennie L., Rigas, Basil
Nitric oxide donating aspirin (NO-ASA), consisting of a traditional ASA to which a NO-releasing moiety is covalently attached, is a promising chemoprevention agent against colon cancer. Its mechanism...
NO-donating aspirin induces phase II enzymes in vitro and in vivo (2005)
Gao, Jianjun, Kashfi, Khosrow, Liu, Xiaoping, Rigas, Basil
Modulation of drug metabolizing enzymes, leading to facilitated elimination of carcinogens represents a successful strategy for cancer chemoprevention. Nitric oxide-donating aspirin (NO-ASA) is a...
Yang, Kan, Fan, Kunhua, Kurihara, Naoto, Shinozaki, Hiroharu, Rigas, Basil, Augenlicht, Leonard, ...
Sulindac and other NSAIDs have been widely studied as potential chemopreventive agents for colon cancer. Short-term studies have shown adenomatous polyps to regress in patients with familial...
Kozoni, Vassiliki, Tsioulias, George, Shiff, Steven, Rigas, Basil
Lithocholic acid (LCA) is implicated in human and experimental animal carcinogenesis. Its effect on apoptosis and proliferation of the colonic epithelium was studied in a 1,2-dimethylhydrazine...
Gastroenterología clínica : manual / Basil Rigas, Howard M. Spiro (1995)
Traducción de:Clinical gastroenterology
Nath, Niharika, Kashfi, Khosrow, Chen, Jie, Rigas, Basil
Dysregulation of the Wnt pathway and altered β-catenin expression are central early events in colorectal carcinogenesis. We studied the ortho, meta, and para (o-, m-, and p-) positional isomers of...
Gao, Jianjun, Liu, Xiaoping, Rigas, Basil
Nitric oxide-donating aspirin (NO-ASA) is a promising chemoprevention agent against colon cancer and other cancers. It consists of traditional ASA to which a NO-releasing moiety is bound through a...
Nath, Niharika, Kashfi, Khosrow, Chen, Jie, Rigas, Basil
Dysregulation of the Wnt pathway and altered β-catenin expression are central early events in colorectal carcinogenesis. We studied the ortho, meta, and para (o-, m-, and p-) positional isomers of...
Gao, Jianjun, Liu, Xiaoping, Rigas, Basil
Nitric oxide-donating aspirin (NO-ASA) is a promising chemoprevention agent against colon cancer and other cancers. It consists of traditional ASA to which a NO-releasing moiety is bound through a...
NO-Donating NSAIDs, PPARδ, and Cancer: Does PPARδ Contribute to Colon Carcinogenesis?
Mackenzie, Gerardo G., Rasheed, Shaheen, Wertheim, William, Rigas, Basil
The chemopreventive NO-donating NSAIDs (NO-NSAIDs; NSAIDs with an NO-releasing moiety) modulate PPARδ and offer the opportunity to revisit the controversial role of PPARδ in carcinogenesis (several...
Ouyang, Nengtai, Williams, Jennie L., Rigas, Basil
The inhibitory effect of NO-donating aspirin (NO-ASA) on colon cancer has been demonstrated in vivo and in vitro but its mechanism is still obscure. We investigated the effect of NO-ASA on...