Brooks, Brian P, Meck, Jeanne M, Haddad, Bassem R, Bendavid, Claude, Blain, Delphine, Toretsky, Jeffrey A
Abstract Background Unbalanced chromosomal translocations may present with a variety of clinical and laboratory findings and provide insight into the functions of genes on the involved chromosomal...
Characterization of Early Genomic Changes in Mammary Glands in High Risk Women (2003)
Because many of the familial breast cancer patients carry a mutation in BRCAl on chromosome l7 or BRCA2 on chromosome 13, the first genetic event that may occur in their mammary glands to begin the...
Detection of Mitochondrial DNA Mutations in Mammary Epithelial Cells in Nipple Aspirate Fluid (1998)
Because optimal methods have not been established for screening and early detection of breast cancer in premenopausal women, there is an urgent need for a variety of new approaches that can augment...
Characterization of Early Genomic Changes in Mammary Glande of High Risk Women (1998)
The purpose of this project was to address the critical question of identifying early genomic changes that occur in the mammary glands of patients with increased predisposition to breast cancer due...
Detection of Mitochondrial DNA Mutations in Mammary Epithelial Cells in Nipple Aspirate Fluid (1998)
Because optimal methods have not been established for screening and early detection of breast cancer in premenopausal women, there is an urgent need for a variety of new approaches that can augment...
Detection of Mitochondrial DNA Mutations in Mammary Epithelial Cells in Nipple Aspirate Fluid (1998)
We have successfully developed a method to isolate free DNA from ductal lavage (DL) and nipple aspirate fluid (NAF), and to use the isolated DNA for mitochondrial DNA (mtDNA) mutation analysis and...
Simbulan-Rosenthal, Cynthia M., Haddad, Bassem R., Rosenthal, Dean S., Weaver, Zoë, Coleman, Allen, Luo, RuiBai, ...
Depletion of poly(ADP-ribose) polymerase (PARP) increases the frequency of recombination, gene amplification, sister chromatid exchanges, and micronuclei formation in cells exposed to genotoxic...
BRCA1 Inhibition of Telomerase Activity in Cultured Cells
Xiong, Jingbo, Fan, Saijun, Meng, Qinghui, Schramm, Laura, Wang, Chenguang, Bouzahza, Boumedienne, ...
Telomerase, an enzyme that maintains telomere length, plays major roles in cellular immortalization and cancer progression. We found that an exogenous BRCA1 gene strongly inhibited telomerase...
Brooks, Brian P, Meck, Jeanne M, Haddad, Bassem R, Bendavid, Claude, Blain, Delphine, Toretsky, Jeffrey A
Simbulan-Rosenthal, Cynthia M., Haddad, Bassem R., Rosenthal, Dean S., Weaver, Zoë, Coleman, Allen, Luo, RuiBai, ...
Depletion of poly(ADP-ribose) polymerase (PARP) increases the frequency of recombination, gene amplification, sister chromatid exchanges, and micronuclei formation in cells exposed to genotoxic...
BRCA1 Inhibition of Telomerase Activity in Cultured Cells
Xiong, Jingbo, Fan, Saijun, Meng, Qinghui, Schramm, Laura, Wang, Chenguang, Bouzahza, Boumedienne, ...
Telomerase, an enzyme that maintains telomere length, plays major roles in cellular immortalization and cancer progression. We found that an exogenous BRCA1 gene strongly inhibited telomerase...