Kiss, Arnold M., Jády, Beáta E., Darzacq, Xavier, Verheggen, Céline, Bertrand, Edouard, Kiss, Tamás
Site‐specific post‐transcriptional conversion of uridines to pseudouridine in ribosomal RNAs and small nuclear RNAs (snRNAs) is directed by guide RNAs which possess the conserved box H and...
In eukaryotic cells, the site-specific 2′-O-ribose methy-lation of ribosomal RNAs (rRNAs) and the U6 spliceosomal small nuclear RNA (snRNA) is directed by small nucleolar RNAs (snoRNAs). The C and...
Nucleolar Factors Direct the 2′-O-Ribose Methylation and Pseudouridylation of U6 Spliceosomal RNA
Ganot, Philippe, Jády, Beáta E., Bortolin, Marie-Line, Darzacq, Xavier, Kiss, Tamás
The nucleolus has long been known as a functionally highly specialized subnuclear compartment where synthesis, posttranscriptional modification, and processing of cytoplasmic rRNAs take place. In...
Cell Cycle-dependent Recruitment of Telomerase RNA and Cajal Bodies to Human Telomeres
Jády, Beáta E., Richard, Patricia, Bertrand, Edouard, Kiss, Tamás
Telomerase is a ribonucleoprotein enzyme that counteracts replicative telomere erosion by adding telomeric sequence repeats onto chromosome ends. Despite its well-established role in telomere...
In eukaryotic cells, the site-specific 2′-O-ribose methy-lation of ribosomal RNAs (rRNAs) and the U6 spliceosomal small nuclear RNA (snRNA) is directed by small nucleolar RNAs (snoRNAs). The C and...
Darzacq, Xavier, Jády, Beáta E., Verheggen, Céline, Kiss, Arnold M., Bertrand, Edouard, Kiss, Tamás
Cajal (coiled) bodies are conserved subnuclear organelles that are present in the nucleoplasm of both animal and plant cells. Although Cajal bodies were first described nearly 100 years ago, their...
In eukaryotes, two distinct classes of small nucleolar RNAs (snoRNAs), namely the fibrillarin-associated box C/D snoRNAs and the Gar1p-associated box H/ACA snoRNAs, direct the site-specific...
A Cajal body-specific pseudouridylation guide RNA is composed of two box H/ACA snoRNA-like domains
Kiss, Arnold M., Jády, Beáta E., Darzacq, Xavier, Verheggen, Céline, Bertrand, Edouard, Kiss, Tamás
Site-specific post-transcriptional conversion of uridines to pseudouridine in ribosomal RNAs and small nuclear RNAs (snRNAs) is directed by guide RNAs which possess the conserved box H and ACA...
Jády, Beáta E., Darzacq, Xavier, Tucker, Karen E., Matera, A.Gregory, Bertrand, Edouard, Kiss, Tamás
Biogenesis of functional spliceosomal small nuclear RNAs (snRNAs) includes the post-transcriptional covalent modification of numerous internal nucleotides. We have recently demonstrated that...
A common sequence motif determines the Cajal body-specific localization of box H/ACA scaRNAs
Richard, Patricia, Darzacq, Xavier, Bertrand, Edouard, Jády, Beáta E., Verheggen, Céline, Kiss, Tamás
Post-transcriptional synthesis of 2′-O-methylated nucleotides and pseudouridines in Sm spliceosomal small nuclear RNAs takes place in the nucleoplasmic Cajal bodies and it is directed by guide RNAs...
Human Box H/ACA Pseudouridylation Guide RNA Machinery†
Kiss, Arnold M., Jády, Beáta E., Bertrand, Edouard, Kiss, Tamás
Pseudouridine, the most abundant modified nucleoside in RNA, is synthesized by posttranscriptional isomerization of uridines. In eukaryotic RNAs, site-specific synthesis of pseudouridines is directed...
Nucleolar Factors Direct the 2′-O-Ribose Methylation and Pseudouridylation of U6 Spliceosomal RNA
Ganot, Philippe, Jády, Beáta E., Bortolin, Marie-Line, Darzacq, Xavier, Kiss, Tamás
The nucleolus has long been known as a functionally highly specialized subnuclear compartment where synthesis, posttranscriptional modification, and processing of cytoplasmic rRNAs take place. In...
In eukaryotic cells, the site-specific 2′-O-ribose methy-lation of ribosomal RNAs (rRNAs) and the U6 spliceosomal small nuclear RNA (snRNA) is directed by small nucleolar RNAs (snoRNAs). The C and...
Darzacq, Xavier, Jády, Beáta E., Verheggen, Céline, Kiss, Arnold M., Bertrand, Edouard, Kiss, Tamás
Cajal (coiled) bodies are conserved subnuclear organelles that are present in the nucleoplasm of both animal and plant cells. Although Cajal bodies were first described nearly 100 years ago, their...
In eukaryotes, two distinct classes of small nucleolar RNAs (snoRNAs), namely the fibrillarin-associated box C/D snoRNAs and the Gar1p-associated box H/ACA snoRNAs, direct the site-specific...
A Cajal body-specific pseudouridylation guide RNA is composed of two box H/ACA snoRNA-like domains
Kiss, Arnold M., Jády, Beáta E., Darzacq, Xavier, Verheggen, Céline, Bertrand, Edouard, Kiss, Tamás
Site-specific post-transcriptional conversion of uridines to pseudouridine in ribosomal RNAs and small nuclear RNAs (snRNAs) is directed by guide RNAs which possess the conserved box H and ACA...
Jády, Beáta E., Darzacq, Xavier, Tucker, Karen E., Matera, A.Gregory, Bertrand, Edouard, Kiss, Tamás
Biogenesis of functional spliceosomal small nuclear RNAs (snRNAs) includes the post-transcriptional covalent modification of numerous internal nucleotides. We have recently demonstrated that...
A common sequence motif determines the Cajal body-specific localization of box H/ACA scaRNAs
Richard, Patricia, Darzacq, Xavier, Bertrand, Edouard, Jády, Beáta E., Verheggen, Céline, Kiss, Tamás
Post-transcriptional synthesis of 2′-O-methylated nucleotides and pseudouridines in Sm spliceosomal small nuclear RNAs takes place in the nucleoplasmic Cajal bodies and it is directed by guide RNAs...
Human Box H/ACA Pseudouridylation Guide RNA Machinery†
Kiss, Arnold M., Jády, Beáta E., Bertrand, Edouard, Kiss, Tamás
Pseudouridine, the most abundant modified nucleoside in RNA, is synthesized by posttranscriptional isomerization of uridines. In eukaryotic RNAs, site-specific synthesis of pseudouridines is directed...
Cell Cycle-dependent Recruitment of Telomerase RNA and Cajal Bodies to Human Telomeres
Jády, Beáta E., Richard, Patricia, Bertrand, Edouard, Kiss, Tamás
Telomerase is a ribonucleoprotein enzyme that counteracts replicative telomere erosion by adding telomeric sequence repeats onto chromosome ends. Despite its well-established role in telomere...
Human telomerase RNA and box H/ACA scaRNAs share a common Cajal body–specific localization signal
Jády, Beáta E., Bertrand, Edouard, Kiss, Tamás
Telomerase is a ribonucleoprotein reverse transcriptase that uses its RNA component as a template for synthesis of telomeric DNA repeats at the ends of linear eukaryotic chromosomes. Here,...
Dynamic remodelling of human 7SK snRNP controls the nuclear level of active P-TEFb
Van Herreweghe, Elodie, Egloff, Sylvain, Goiffon, Isabelle, Jády, Beáta E, Froment, Carine, Monsarrat, Bernard, ...
The 7SK small nuclear RNA (snRNA) regulates RNA polymerase II transcription elongation by controlling the protein kinase activity of the positive transcription elongation factor b (P-TEFb). In...
The Hsp90 chaperone controls the biogenesis of L7Ae RNPs through conserved machinery
Boulon, Séverine, Marmier-Gourrier, Nathalie, Pradet-Balade, Bérengère, Wurth, Laurence, Verheggen, Céline, Jády, Beáta E., ...
RNA-binding proteins of the L7Ae family are at the heart of many essential ribonucleoproteins (RNPs), including box C/D and H/ACA small nucleolar RNPs, U4 small nuclear RNP, telomerase, and messenger...
Human U1 snRNA forms a new chromatin-associated snRNP with TAF15
Jobert, Laure, Pinzón, Natalia, Van Herreweghe, Elodie, Jády, Beáta E, Guialis, Apostolia, Kiss, Tamás, ...
The U1 small nuclear RNA (snRNA)—in the form of the U1 spliceosomal Sm small nuclear ribonucleoprotein particle (snRNP) that contains seven Sm and three U1-specific RNP proteins—has a crucial...