Ben Woodman

Hsp27 overexpression in the R6/2 mouse model of Huntington's disease: chronic neurodegeneration does not induce Hsp27 activation (2007)

Zourlidou, Alexandra, Gidalevitz, Tali, Kristiansen, Mark, Landles, Christian, Woodman, Ben, Wells, Dominic J., ...

Huntington's disease (HD) is caused by an expanded polyglutamine tract in the huntingtin protein. Mitochondrial dysfunction and free radical damage occur in both R6/2 mice and HD patient brains and...

Increased metabolism in the R6/2 mouse model of Huntington's disease. (2007)

Bacos, Karl, Wood, Nigel I, Lindqvist, Andreas, Wierup, Nils, Woodman, Ben, ...

Abstract is not available

Hsp27 overexpression in the R6/2 mouse model of Huntington's Disease: Chronic Neurodegeneration does not Induce Hsp27 Activation (2007)

Zourlidou, Alexandra, Gidalevitz, Tali, Kristiansen, Mark, Landles, Christian, Woodman, Ben, Wells, Dominic J., ...

Huntington's disease (HD) is caused by an expanded polyglutamine tract in the huntingtin protein. Mitochondrial dysfunction and free radical damage occur in both R6/2 mice and HD patient brains and...

Proteasome impairment does not contribute to pathogenesis in R6/2 Huntington's disease mice: exclusion of proteasome activator REG{gamma} as a therapeutic target (2006)

Bett, John S., Goellner, Geoffrey M., Woodman, Ben, Pratt, Gregory, Rechsteiner, Martin, Bates, Gillian P.

Huntington's disease (HD) is one of a group of neurodegenerative disorders caused by the pathological expansion of a glutamine tract. A hallmark of these so-called polyglutamine diseases is the...

Proteasome impairment does not contribute to pathogenesis in R6/2 Huntington's disease mice: exclusion of proteasome activator REG{gamma} as a therapeutic target (2006)

Bett, John S., Goellner, Geoffrey M., Woodman, Ben, Pratt, Gregory, Rechsteiner, Martin, Bates, Gillian P.

Reduction of GnRH and infertility in the R6/2 mouse model of Huntington's disease. (2005)

Papalexi, Eugenia, Persson, Anna, Bjorkqvist, Maria, Petersén, Asa, Woodman, Ben, Bates, Gillian P, ...

Abstract is not available

Contribution of nuclear and extranuclear polyQ to neurological phenotypes in mouse models of Huntington's disease (2005)

Benn, Caroline L., Landles, Christian, Li, He, Strand, Andrew D., Woodman, Ben, Sathasivam, Kirupa, ...

In postmortem Huntington's disease brains, mutant htt is present in both nuclear and cytoplasmic compartments. To dissect the impact of nuclear and extranuclear mutant htt on the initiation and...

Progressive decrease in chaperone protein levels in a mouse model of huntington's disease and induction of stress proteins as a therapeutic approach (2004)

Hay, David G., Sathasivam, Kirupa, Tobaben, Sönke, Stahl, Bernd, Marber, Michael, Mestril, Ruben, ...

The manipulation of chaperone levels has been shown to inhibit aggregation and/or rescue cell death in cell culture, S. cerevisiae, C. elegans and D. melanogaster models of Huntington's disease (HD)...

Progressive decrease in chaperone protein levels in a mouse model of Huntington's disease and induction of stress proteins as a therapeutic approach (2004)

Hay, David G., Sathasivam, Kirupa, Tobaben, Sönke, Stahl, Bernd, Marber, Michael, Mestril, Ruben, ...

The manipulation of chaperone levels has been shown to inhibit aggregation and/or rescue cell death in Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster and cell culture...

Progressive decrease in chaperone protein levels in a mouse model of huntington's disease and induction of stress proteins as a therapeutic approach (2004)

Hay, David G., Sathasivam, Kirupa, Tobaben, Sönke, Stahl, Bernd, Marber, Michael, Mestril, Ruben, ...

The manipulation of chaperone levels has been shown to inhibit aggregation and/or rescue cell death in cell culture, S. cerevisiae, C. elegans and D. melanogaster models of Huntington's disease (HD)...

Centrosome disorganization in fibroblast cultures derived from R6/2 Huntington's disease (HD) transgenic mice and HD patients (2001)

Sathasivam, Kirupa, Woodman, Ben, Mahal, Amabirpal, Bertaux, Fabien, Wanker, Erich E., Shima, Dave T., ...

Huntington’s disease (HD) is a progressive neurological disorder caused by a CAG/polyglutamine repeat expansion. We have previously generated the R6/2 mouse model that expresses exon 1 of...

DNA instability in postmitotic neurons

Gonitel, Roman, Moffitt, Hilary, Sathasivam, Kirupa, Woodman, Ben, Detloff, Peter J., Faull, Richard L. M., ...

Huntington's disease (HD) is caused by a CAG repeat expansion that is unstable upon germ-line transmission and exhibits mosaicism in somatic tissues. We show that region-specific CAG repeat mosaicism...

A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease

Björkqvist, Maria, Wild, Edward J., Thiele, Jenny, Silvestroni, Aurelio, Andre, Ralph, Lahiri, Nayana, ...

Huntington's disease (HD) is an inherited neurodegenerative disorder characterized by both neurological and systemic abnormalities. We examined the peripheral immune system and found widespread...

Genetic Knock-Down of HDAC7 Does Not Ameliorate Disease Pathogenesis in the R6/2 Mouse Model of Huntington's Disease

Benn, Caroline L., Butler, Rachel, Mariner, Lydia, Nixon, Jude, Moffitt, Hilary, Mielcarek, Michal, ...

Huntington's disease (HD) is an inherited, progressive neurological disorder caused by a CAG/polyglutamine repeat expansion, for which there is no effective disease modifying therapy. In recent...