Pandey, Priyanka, Brors, Benedikt, Srivastava, Prashant K, Bott, Andrea, Boehn, Susanne NE, Groene, Herrmann-Josef, ...
Abstract Background MicroRNAs (miRNAs) play key roles in mammalian gene expression and several cellular processes, including differentiation, development, apoptosis and cancer pathomechanisms....
Westermann, Frank, Muth, Daniel, Benner, Axel, Bauer, Tobias, Henrich, Kai-Oliver, Oberthuer, André, ...
Abstract Background Amplified MYCN oncogene resulting in deregulated MYCN transcriptional activity is observed in 20% of neuroblastomas and identifies a highly aggressive subtype. In MYCN single-copy...
BIOINFORMATICS ORIGINAL PAPER (2008)
Gene Expression, Theodora Manoli, Norbert Gretz, Hermann-josef Gröne, Marc Kenzelmann, Benedikt Brors
doi:10.1093/bioinformatics/btl424 Group testing for pathway analysis improves comparability of different microarray datasets
Er Schramm, Jo V, Johannes H. Schulte, Sabine Dreesmann, Lars Kaderali, Benedikt Brors, ...
Abstract Purpose: To assess the feasibility of predicting neuroblastoma outcome using highly parallel quantitative real-time PCR data. Experimental Design: We generated expression profiles of 63...
Recommendations for experimental design of standard experiments (2008)
Author(s) Christian Lawerenz, Tim Beissbarth, Ulrich Mannsmann, Benedikt Brors
• Define the goal of your experiment in a quantitative way: Make an appropriate structural compromise between the most informative and most robust set-up for your experiment. • For cDNA...
Temporal transcriptomic analysis of the Listeria monocytogenesEGD-e σBregulon (2008)
Hain, Torsten, Hossain, Hamid, Chatterjee, Som S, Machata, Silke, Volk, Ute, Wagner, Sandra, ...
Abstract Background The opportunistic food-borne gram-positive pathogen Listeria monocytogenes can exist as a free-living microorganism in the environment and grow in the cytoplasm of vertebrate and...
Temporal transcriptomic analysis of the Listeria monocytogenes EGD-e sigmaB regulon (2008)
Hain, Torsten, Hossain, Hamid, Chatterjee, Som S, Machata, Silke, Volk, Ute, Wagner, Sandra, ...
Background The opportunistic food-borne gram-positive pathogen Listeria monocytogenes can exist as a free-living microorganism in the environment and grow in the cytoplasm of vertebrate and...
Bmc Genomics, Priyanka P, Benedikt Brors, Prashant K Srivastava, Andrea Bott, Susanne Ne Boehn, ...
Research article Microarray-based approach identifies microRNAs and their target functional patterns in polycystic kidney disease
Warnat, Patrick, Oberthuer, André, Fischer, Matthias, Westermann, Frank, Eils, Roland, Brors, Benedikt
Abstract Background Neuroblastoma patients show heterogeneous clinical courses ranging from life-threatening progression to spontaneous regression. Recently, gene expression profiles of neuroblastoma...
Svetlana Bulashevska, Ezekiel Adebiyi, Benedikt Brors, Roland Eils
The most fatal and prevalent form of malaria is caused by the bloodborne pathogen Plasmodium falciparum (henceforth P.f). Annually, approximately three million people died of malaria. Despite P.f...
Oberthuer, André, Berthold, Frank, Warnat, Patrick, Hero, Barbara, Kahlert, Yvonne, Spitz, Rüdiger, ...
PURPOSE: To develop a gene expression–based classifier for neuroblastoma patients that reliably predicts courses of the disease. PATIENTS AND METHODS: Two hundred fifty-one neuroblastoma specimens...
Group testing for pathway analysis improves comparability of different microarray datasets (2006)
Manoli, Theodora, Gretz, Norbert, Gröne, Hermann-Josef, Kenzelmann, Marc, Eils, Roland, Brors, Benedikt
Motivation: The wide use of DNA microarrays for the investigation of the cell transcriptome triggered the invention of numerous methods for the processing of microarray data and lead to a growing...
Argonaute--a database for gene regulation by mammalian microRNAs (2006)
Shahi, Priyanka, Loukianiouk, Serguei, Bohne-Lang, Andreas, Kenzelmann, Marc, Küffer, Stefan, Maertens, Sabine, ...
MicroRNAs (miRNAs) constitute a recently discovered class of small non-coding RNAs that regulate expression of target genes either by decreasing the stability of the target mRNA or by translational...
Warnat, Patrick, Eils, Roland, Brors, Benedikt
Abstract Background The extensive use of DNA microarray technology in the characterization of the cell transcriptome is leading to an ever increasing amount of microarray data from cancer studies....
Fellenberg,Kurt, Hauser,Nicole C., Brors,Benedikt, Hoheisel,Jörg D., Vingron,Martin
Motivation: Microarray technology provides access to expression levels of thousands of genes at once, producing large amounts of data. These datasets are valuable only if they are annotated by...
Fellenberg, Kurt, Hauser, Nicole C., Brors, Benedikt, Hoheisel, Jörg D., Vingron, Martin
Motivation: Microarray technology provides access to expression levels of thousands of genes at once, producing large amounts of data. These datasets are valuable only if they are annotated by...
Düsseldorf, Universiẗat, Diss., 1999.
Correspondence analysis applied to microarray data
Fellenberg, Kurt, Hauser, Nicole C., Brors, Benedikt, Neutzner, Albert, Hoheisel, Jörg D., Vingron, Martin
Correspondence analysis is an explorative computational method for the study of associations between variables. Much like principal component analysis, it displays a low-dimensional projection of the...
Schoch, Claudia, Kohlmann, Alexander, Schnittger, Susanne, Brors, Benedikt, Dugas, Martin, Mergenthaler, Susanne, ...
Acute myeloid leukemia (AML) is a heterogeneous group of genetically defined diseases. Their classification is important with regard to prognosis and treatment. We performed microarray analyses for...
Argonaute—a database for gene regulation by mammalian microRNAs
Shahi, Priyanka, Loukianiouk, Serguei, Bohne-Lang, Andreas, Kenzelmann, Marc, Küffer, Stefan, Maertens, Sabine, ...
MicroRNAs (miRNAs) constitute a recently discovered class of small non-coding RNAs that regulate expression of target genes either by decreasing the stability of the target mRNA or by translational...
Correspondence analysis applied to microarray data
Fellenberg, Kurt, Hauser, Nicole C., Brors, Benedikt, Neutzner, Albert, Hoheisel, Jörg D., Vingron, Martin
Correspondence analysis is an explorative computational method for the study of associations between variables. Much like principal component analysis, it displays a low-dimensional projection of the...
Schoch, Claudia, Kohlmann, Alexander, Schnittger, Susanne, Brors, Benedikt, Dugas, Martin, Mergenthaler, Susanne, ...
Acute myeloid leukemia (AML) is a heterogeneous group of genetically defined diseases. Their classification is important with regard to prognosis and treatment. We performed microarray analyses for...
Argonaute—a database for gene regulation by mammalian microRNAs
Shahi, Priyanka, Loukianiouk, Serguei, Bohne-Lang, Andreas, Kenzelmann, Marc, Küffer, Stefan, Maertens, Sabine, ...
MicroRNAs (miRNAs) constitute a recently discovered class of small non-coding RNAs that regulate expression of target genes either by decreasing the stability of the target mRNA or by translational...
Warnat, Patrick, Oberthuer, André, Fischer, Matthias, Westermann, Frank, Eils, Roland, Brors, Benedikt
Temporal transcriptomic analysis of the Listeria monocytogenes EGD-e σB regulon
Hain, Torsten, Hossain, Hamid, Chatterjee, Som S, Machata, Silke, Volk, Ute, Wagner, Sandra, ...
Gotter, Jörn, Brors, Benedikt, Hergenhahn, Manfred, Kyewski, Bruno
Promiscuous expression of tissue-specific self-antigens in the thymus imposes T cell tolerance and protects from autoimmune diseases, as shown in animal studies. Analysis of promiscuous gene...
Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels
Derbinski, Jens, Gäbler, Jana, Brors, Benedikt, Tierling, Sascha, Jonnakuty, Sunitha, Hergenhahn, Manfred, ...
The role of central tolerance induction has recently been revised after the discovery of promiscuous expression of tissue-restricted self-antigens in the thymus. The extent of tissue representation...
Bar-Joseph, Ziv, Siegfried, Zahava, Brandeis, Michael, Brors, Benedikt, Lu, Yong, Eils, Roland, ...
Characterization of the transcriptional regulatory network of the normal cell cycle is essential for understanding the perturbations that lead to cancer. However, the complete set of cycling genes in...
Pandey, Priyanka, Brors, Benedikt, Srivastava, Prashant K, Bott, Andrea, Boehn, Susanne NE, Groene, Herrmann-Josef, ...
Konrad, Andreas, Wies, Effi, Thurau, Mathias, Marquardt, Gaby, Naschberger, Elisabeth, Hentschel, Sonja, ...
Human herpesvirus 8 (HHV-8) is the etiologic agent of Kaposi's sarcoma and primary effusion lymphoma. Activation of the cellular transcription factor nuclear factor-kappa B (NF-κB) is essential for...
Westermann, Frank, Muth, Daniel, Benner, Axel, Bauer, Tobias, Henrich, Kai-Oliver, Oberthuer, André, ...
Differences in MYCN/c-MYC target gene expression are associated with distinct neuroblastoma subtypes and clinical outcome.
New Insights into the Genetic Regulation of Plasmodium Falciparum Obtained by Bayesian Modeling
Bulashevska, Svetlana, Adebiyi, Ezekiel, Brors, Benedikt, Eils, Roland
The most fatal and prevalent form of malaria is caused by the bloodborne pathogen Plasmodium falciparum (henceforth P.f). Annually, approximately three million people died of malaria. Despite P.f...