Bengt Jeppsson

Use of the probiotic Lactobacillus plantarum299 to reduce pathogenic bacteria in the oropharynx of intubated patients: a randomised controlled open pilot study (2008)

Klarin, Bengt, Molin, Göran, Jeppsson, Bengt, Larsson, Anders

Abstract Introduction Ventilator-associated pneumonia (VAP) is usually caused by aspiration of pathogenic bacteria from the oropharynx. Oral decontamination with antiseptics, such as chlorhexidine...

Local radiotherapy of exposed murine small bowel: Apoptosis and inflammation (2008)

Polistena, Andrea, Johnson, Louis, Ohiami-Masseron, Salomé, Wittgren, Lena, Bäck, Sven, Thornberg, Charlotte, ...

Abstract Background Preoperative radiotherapy of the pelvic abdomen presents with complications mostly affecting the small bowel. The aim of this study was to define the features of early...

Bifidobacterium infantisstrains with and without a combination of Oligofructose and Inulin (OFI) attenuate inflammation in DSS-induced colitis in rats (2006)

Osman, Nadia, Adawi, Diya, Molin, Göran, Ahrne, Siv, Berggren, Anna, Jeppsson, Bengt

Abstract Background Pathogenesis of inflammatory bowel disease is thought to be through different factors and there is a relationship between the gut flora and the risk of its development. Probiotics...

Adhesion of the probiotic bacterium Lactobacillus plantarum299v onto the gut mucosa in critically ill patients: a randomised open trial (2005)

Klarin, Bengt, Johansson, Marie-Louise, Molin, Göran, Larsson, Anders, Jeppsson, Bengt

Abstract Introduction To achieve any possible positive effect on the intestinal mucosa cells it is important that probiotics adhere tightly onto the intestinal mucosa. It has been shown in healthy...

Activation of cPLA2 is required for leukotriene D4-induced proliferation in colon cancer cells (2005)

Parhamifar, Ladan, Jeppsson, Bengt, Sjölander, Anita

It is well documented that prolonged inflammatory conditions, particularly those relating to the colon, have been shown to induce cancer. We have previously demonstrated that the pro-inflammatory...

Activation of cPLA2 is required for leukotriene D4-induced proliferation in colon cancer cells (2005)

Parhamifar, Ladan, Jeppsson, Bengt, Sjölander, Anita

It is well documented that prolonged inflammatory conditions, particularly those relating to the colon, have been shown to induce cancer. We have previously demonstrated that the pro-inflammatory...

Radiation enteropathy and leucocyte-endothelial cell reactions in a refined small bowel model (2004)

Johnson, Louis, Riaz, Amjid, Adawi, Diya, Wittgren, Lena, Bäck, Sven, Thornberg, Charlotte, ...

Abstract Background Leucocyte recruitment and inflammation are key features of high dose radiation-induced tissue injury. The inflammatory response in the gut may be more pronounced following...

Bacterial translocation: Impact of probiotics (2004)

Jeppsson, Bengt, Mangell, Peter, Adawi, Diya, Molin, Göran

There is a considerable amount of data in humans showing that patients who cannot take in nutrients enterally have more organ failure in the intensive care unit, a less favourable prognosis, and a...

Lactobacillus plantarum 299v inhibits Escherichia coli-induced intestinal permeability. (2002)

Mangell, Peter, Nejdfors, Pernilla, Wang, Mei, Ahrné, Siv, Weström, Bjorn, Thorlacius, Henrik, ...

The purpose of this work was to investigate whether a probiotic bacterium, Lactobacillus plantarum 299v, could affect Escherichia coli-induced passage of mannitol across the intestinal wall....

Anastomotic healing in the rat colon: comparison between a radiological method, breaking strength and bursting pressure. (2002)

Månsson, Peter, Zhang, Xiao Wei, Jeppsson, Bengt, Thorlacius, Henrik

Background and aims: While mechanical parameters (breaking strength, bursting pressure) are used to measure colonic anastomotic healing, reported values are inconsistent. This study developed a novel...

Liver Resection: Prolonged Inflow Occlusion in Human Cirrhotic Livers (1996)

Bengt Jeppsson

To evaluate the tolerance of the cirrhotic liver to extended warm ischaemia, 47 patients with cirrhosis who underwent liver,resection over a 4-year period were studied retrospectively. Three groups...

Implantable Drainage After Major Abdominal Surgery in Compromised Patients (1990)

Roland Andersson, Bengt Jeppsson, Anna Holmberg, Stig Bengmark

The risk of superinfection following routine abdominal drainage after major surgery is debated. Especially in patients with malignant diseases and a compromised host defense, this might be a factor...

Staphylococcal Enterotoxin A-Induced Hepatotoxicity Is Predominately Mediated by Fas Ligand (CD95L)

Klintman, Daniel, Li, Xiang, Sato, Tohru, Wang, Yusheng, Jeppsson, Bengt, Thorlacius, Henrik

The molecular mechanisms of hepatotoxicity induced by enterotoxin (superantigen) from Gram-positive bacteria and endotoxin (lipopolysaccharide) from Gram-negative bacteria were examined. It was found...

p38 Mitogen-Activated Protein Kinase-Dependent Chemokine Production, Leukocyte Recruitment, and Hepatocellular Apoptosis in Endotoxemic Liver Injury

Klintman, Daniel, Li, Xiang, Santen, Stefan, Schramm, Rene, Jeppsson, Bengt, Thorlacius, Henrik

Cellular responses to stress signals are integrated by mitogen-activated protein kinases (MAPKs). We demonstrate that inhibition of p38 MAPK signaling protects against endotoxin-induced formation of...

Staphylococcal Enterotoxin A-Induced Hepatotoxicity Is Predominately Mediated by Fas Ligand (CD95L)

Klintman, Daniel, Li, Xiang, Sato, Tohru, Wang, Yusheng, Jeppsson, Bengt, Thorlacius, Henrik

The molecular mechanisms of hepatotoxicity induced by enterotoxin (superantigen) from Gram-positive bacteria and endotoxin (lipopolysaccharide) from Gram-negative bacteria were examined. It was found...

p38 Mitogen-Activated Protein Kinase-Dependent Chemokine Production, Leukocyte Recruitment, and Hepatocellular Apoptosis in Endotoxemic Liver Injury

Klintman, Daniel, Li, Xiang, Santen, Stefan, Schramm, Rene, Jeppsson, Bengt, Thorlacius, Henrik

Cellular responses to stress signals are integrated by mitogen-activated protein kinases (MAPKs). We demonstrate that inhibition of p38 MAPK signaling protects against endotoxin-induced formation of...

Interleukin-10 mediates the protective effect of Linomide by reducing CXC chemokine production in endotoxin-induced liver injury

Li, Xiang, Klintman, Daniel, Sato, Tohru, Hedlund, Gunnar, Schramm, René, Jeppsson, Bengt, ...

The immunomodulator Linomide has been shown to protect against septic liver injury by reducing hepatic accumulation of leukocytes although the detailed anti-inflammatory mechanisms remain elusive....

Evidence-based medicine in HBP surgery: Is there any?

Jeppsson, Bengt, Thorlacius, Henrik

Background. Evidence-based medicine (EBM) has become widely accepted as a basis for clinical decision in many fields of medicine. This review examines the specific role of EBM in hepato-biliary and...

Implantable Drainage After Major Abdominal Surgery in Compromised Patients

Andersson, Roland, Jeppsson, Bengt, Holmberg, Anna, Bengmark, Stig

The risk of superinfection following routine abdominal drainage after major surgery is debated. Especially in patients with malignant diseases and a compromised host defense, this might be a factor...

Liver Resection: Prolonged Inflow Occlusion in Human Cirrhotic Livers

Jeppsson, Bengt

To evaluate the tolerance of the cirrhotic liver to extended warm ischaemia, 47 patients with cirrhosis who underwent liver,resection over a 4-year period were studied retrospectively. Three groups...