Bengt Saltin

PHYSICAL FITNESS IN TERMS OF MAXIMAL OXYGEN INTAKE OF NOMADIC LAPPS. (1998)

Andersen, K. Lange, Elsner,R. E., Saltin,Bengt, Hermansen,Lars

Physical fitness in terms of aerobic working capacity was measured in nomadic Lapps living in the northern part of the Scandinavian peninsula. 49 men between 10 and 55 years of age, and 21 girls were...

Peak skeletal muscle perfusion is maintained in patients with chronic heart failure when only a small muscle mass is exercised (1997)

Magnusson, Gi, Kaijser, Lennart, Sylvén, Christer, Karlberg, Karl-Erik, Isberg, Bengt, Saltin, Bengt

Objectives: The issue to be resolved was whether peripheral leg blood flow in patients with chronic heart failure (CHF) is reduced by low local flow capacity or as a function of the amount of muscle...

Glucose clearance is higher in arm than leg muscle in type 2 diabetes

Olsen, David B, Sacchetti, Massimo, Dela, Flemming, Ploug, Thorkil, Saltin, Bengt

Insulin-mediated glucose clearance (GC) is diminished in type 2 diabetes. Skeletal muscle has been estimated to account for essentially all of the impairment. Such estimations were based on leg...

High triacylglycerol turnover rate in human skeletal muscle

Sacchetti, Massimo, Saltin, Bengt, Olsen, David B, Van Hall, Gerrit

In the present study we investigated the relationship between plasma fatty acids (FA) and intramuscular triacylglycerol (IMTAG) kinetics of healthy volunteers. With this aim [U-13C]-palmitate was...

Glucose clearance is higher in arm than leg muscle in type 2 diabetes

Olsen, David B, Sacchetti, Massimo, Dela, Flemming, Ploug, Thorkil, Saltin, Bengt

Insulin-mediated glucose clearance (GC) is diminished in type 2 diabetes. Skeletal muscle has been estimated to account for essentially all of the impairment. Such estimations were based on leg...

High triacylglycerol turnover rate in human skeletal muscle

Sacchetti, Massimo, Saltin, Bengt, Olsen, David B, Van Hall, Gerrit

In the present study we investigated the relationship between plasma fatty acids (FA) and intramuscular triacylglycerol (IMTAG) kinetics of healthy volunteers. With this aim [U-13C]-palmitate was...

Maximal exercise and muscle oxygen extraction in acclimatizing lowlanders and high altitude natives

Lundby, Carsten, Sander, Mikael, Van Hall, Gerrit, Saltin, Bengt, Calbet, José A L

The tight relation between arterial oxygen content and maximum oxygen uptake () within a given person at sea level is diminished with altitude acclimatization. An explanation often suggested for this...

Effect of muscle glycogen on glucose, lactate and amino acid metabolism during exercise and recovery in human subjects

Blomstrand, Eva, Saltin, Bengt

Eight subjects performed two-legged exercise, one leg with low and the other with normal muscle glycogen content. The purpose was to study the effect of low initial muscle glycogen content on the...

Heat production in human skeletal muscle at the onset of intense dynamic exercise

González-Alonso, José, Quistorff, Bjørn, Krustrup, Peter, Bangsbo, Jens, Saltin, Bengt

We hypothesised that heat production of human skeletal muscle at a given high power output would gradually increase as heat liberation per mole of ATP produced rises when energy is derived from...

Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6

Steensberg, Adam, Van Hall, Gerrit, Osada, Takuya, Sacchetti, Massimo, Saltin, Bengt, Pedersen, Bente Klarlund

Plasma interleukin (IL)-6 concentration is increased with exercise and it has been demonstrated that contracting muscles can produce IL- The question addressed in the present study was whether the...

Exercising skeletal muscle blood flow in humans responds to reduction in arterial oxyhaemoglobin, but not to altered free oxygen

González-Alonso, José, Richardson, Russell S, Saltin, Bengt

We hypothesised that reducing arterial oxyhaemoglobin (O2Hba) with carbon monoxide (CO) in both normoxia and hyperoxia, or acute hypoxia would cause similar compensatory increases in human skeletal...

Interleukin-6 production in contracting human skeletal muscle is influenced by pre-exercise muscle glycogen content

Steensberg, Adam, Febbraio, Mark A, Osada, Takuya, Schjerling, Peter, Van Hall, Gerrit, Saltin, Bengt, ...

Prolonged exercise results in a progressive decline in glycogen content and a concomitant increase in the release of the cytokine interleukin-6 (IL-6) from contracting muscle. This study tests the...

The exercise metaboreflex is maintained in the absence of muscle acidosis: insights from muscle microdialysis in humans with McArdle's disease

Vissing, John, MacLean, David A, Vissing, Susanne F, Sander, Mikael, Saltin, Bengt, Haller, Ronald G

In McArdle's disease, muscle glycogenolysis is blocked, which results in absent lactate and enhanced ammonia production in working muscle. Using McArdle patients as an experimental model, we studied...

Reduced glycogen availability is associated with an elevation in HSP72 in contracting human skeletal muscle

Febbraio, Mark A, Steensberg, Adam, Walsh, Rory, Koukoulas, Irene, Van Hall, Gerrit, Saltin, Bengt, ...

To test the hypothesis that a decrease in intramuscular glycogen availability may stimulate heat shock protein expression, seven men depleted one leg of muscle glycogen the day before performing...

Muscle glycogen content and glucose uptake during exercise in humans: influence of prior exercise and dietary manipulation

Steensberg, Adam, Van Hall, Gerrit, Keller, Charlotte, Osada, Takuya, Schjerling, Peter, Klarlund Pedersen, Bente, ...

There are many factors that can influence glucose uptake by contracting skeletal muscle during exercise and although one may be intramuscular glycogen content, this relationship is at present not...

Influence of pre-exercise muscle glycogen content on exercise-induced transcriptional regulation of metabolic genes

Pilegaard, Henriette, Keller, Charlotte, Steensberg, Adam, Wulff Helge, Jørn, Klarlund Pedersen, Bente, Saltin, Bengt, ...

Transcription of metabolic genes is transiently induced during recovery from exercise in skeletal muscle of humans. To determine whether pre-exercise muscle glycogen content influences the magnitude...

Dissociation between muscle tricarboxylic acid cycle pool size and aerobic energy provision during prolonged exercise in humans

Gibala, Martin J, González-Alonso, José, Saltin, Bengt

It has been suggested that a decrease in the total concentration of tricarboxylic acid cycle intermediates (TCAIs) - secondary to a reduction in glycogen availability - compromises oxidative energy...

Cytochrome P450 2C9 plays an important role in the regulation of exercise-induced skeletal muscle blood flow and oxygen uptake in humans

Hillig, Thore, Krustrup, Peter, Fleming, Ingrid, Osada, Takuya, Saltin, Bengt, Hellsten, Ylva

Previous studies show that exercise-induced hyperaemia is unaffected by systemic inhibition of nitric oxide synthase (NOS) and it has been proposed that this may be due to compensation by other...

Exercise induces transient transcriptional activation of the PGC-1α gene in human skeletal muscle

Pilegaard, Henriette, Saltin, Bengt, Neufer, P Darrell

Endurance exercise training induces mitochondrial biogenesis in skeletal muscle. The peroxisome proliferator activated receptor co-activator 1α (PGC-1α) has recently been identified as a nuclear...

The effect of ageing and immobilization on structure and function of human skeletal muscle fibres

D'Antona, Giuseppe, Pellegrino, Maria Antonietta, Adami, Raffaella, Rossi, Rosetta, Carlizzi, Carmine Naccari, Canepari, Monica, ...

Biopsy samples were taken from vastus lateralis muscle of seven young (YO, age 30.2 ± 2.2 years), and seven elderly (EL, age 72.7 ± 2.3 years) subjects and two elderly subjects whose right leg had...

Inhibition of nitric oxide and prostaglandins, but not endothelial-derived hyperpolarizing factors, reduces blood flow and aerobic energy turnover in the exercising human leg

Mortensen, Stefan P, González-Alonso, José, Damsgaard, Rasmus, Saltin, Bengt, Hellsten, Ylva

Prostaglandins, nitric oxide (NO) and endothelial-derived hyperpolarizing factors (EDHFs) are substances that have been proposed to be involved in the regulation of skeletal muscle blood flow during...

Exercise hyperaemia: magnitude and aspects on regulation in humans

Saltin, Bengt

The primary function of the cardiovascular system is to supply oxygen to tissues and organs in the body. When muscles contract the aerobic demands are met by an increase in oxygen delivery both at...

During hypoxic exercise some vasoconstriction is needed to match O2 delivery with O2 demand at the microcirculatory level

Lundby, Carsten, Boushel, Robert, Robach, Paul, Møller, Kirsten, Saltin, Bengt, Calbet, José A L

To test the hypothesis that the increased sympathetic tonus elicited by chronic hypoxia is needed to match O2 delivery with O2 demand at the microvascular level eight male subjects were investigated...