Hakansson, Krister, Rovio, Suvi, Helkala, Eeva-Liisa, Vilska, Anna-Riitta, Winblad, Bengt, Soininen, Hilkka, ...
Objectives To evaluate whether mid-life marital status is related to cognitive function in later life. Design Prospective population based study with an average follow-up of 21 years. Setting Kuopio...
Hakansson, Krister, Rovio, Suvi, Helkala, Eeva-Liisa, Vilska, Anna-Riitta, Winblad, Bengt, Soininen, Hilkka, ...
Objectives To evaluate whether mid-life marital status is related to cognitive function in later life. Design Prospective population based study with an average follow-up of 21 years. Setting Kuopio...
Roxana Nat, Gunilla Johansson, Cover Gheorghe Popescu, Bengt Winblad, Luiza Spiru
Research of Romania and the Medical
APOE and cognitive decline in preclinical Alzheimer's disease and non-demented aging (2004)
Bunce,David, Fratiglioni,Laura, Small,Brent J., Winblad,Bengt, Bäckman,Lars
APOE and cognitive decline in preclinical Alzheimer's disease and non-demented aging (2004)
Bunce, David, Fratiglioni, Laura, Small, Brent J., Winblad, Bengt, Bäckman, Lars
Karp, Anita, Kåreholt, Ingemar, Qiu, Chengxuan, Bellander, Tom, Winblad, Bengt, Fratiglioni, Laura
In this study, the authors evaluated whether the association between low educational level and increased risk of Alzheimer’s disease (AD) and dementia may be explained by occupation-based...
Cingulate cortex hypoperfusion predicts Alzheimer's disease in mild cognitive impairment (2002)
Huang, Chaorui, Wahlund, Lars-Olof, Svensson, Leif, Winblad, Bengt, Julin, Per
Abstract Background Mild cognitive impairment (MCI) was recently described as a heterogeneous group with a variety of clinical outcomes and high risk to develop Alzheimer's disease (AD). Regional...
Pharmacotherapy of Alzheimer's disease: is there a need to redefine treatment success? (2001)
Winblad, Bengt, Brodaty, Henry, Gauthier, Serge, Morris, John C., Orgogozo, Jean-Marc, Rockwood, Kenneth, ...
The traditional aim of Alzheimer's disease treatment in clinical trials has been to improve cognitive abilities. It has become increasingly clear, however, that other aspects are important in...
Guo, Zhenchao, Fratiglioni, Laura, Viitanen, Matti, Lannfelt, Lars, Basun, Hans, Fastbom, Johan, ...
The authors examined the impact of the apolipoprotein E (APOE)*ϵ4 allele on Alzheimer's disease incidence in relation to use of antihypertensive medication. A population-based (Kungsholmen...
Wang, Hui-Xin, Fratiglioni, Laura, Frisoni, Giovanni B., Viitanen, Matti, Winblad, Bengt
The authors tested the hypothesis that smoking exerts a protective effect on Alzheirmer's disease or dementia in a population-based cohort of 668 people aged 75–101 years (Sweden). Smoking was...
Frisoni, Giovanni B., Fratiglioni, Laura, Fastbom, Johan, Viitanen, Matti, Winblad, Bengt
Nondemented older subjects with cognitive impairment are at higher risk of death than are mentally intact persons. It is unknown whether the effect of cognitive impairment on mortality is independent...
Guo, Zhenchao, Wills, Phillippa, Viitanen, Matti, Fastbom, Johan, Winblad, Bengt
The authors examined the effects of cognitive function, as assessed by the Mini-Mental State Examination, and drug use on the incidence of hip fracture in a community-based Swedish population of...
Drug use by demented and non-demented elderly people (1997)
WILLS, PHILLIPA, CLAESSON, CECILIA B., FRATIGLIONI, LAURA, FASTBOM, JOHAN, THORSLUND, MATS, WINBLAD, BENGT
Aim: to determine the use of drugs by demented and non-demented elderly people in a population, by dementia status and type, age, sex and accommodation type. Method: data were obtained from the...
Guo, Zhenchao, Fratiglioni, Laura, Winblad, Bengt, Viitanen, Matti
The authors examined the association of blood pressure with cognitive function as assessed by the Mini-Mental State Examination (MMSE) in a community-based Swedish cohort of 1,736 people aged...
Johnston, Janet, Lillus, Lena, Axelman, Karin, Cowburn, Richard, Johansson, Kurt, Vlltanen, Matti, ...
Elmros, Theodor, Holm, Stig, Kjellberg, Erik, Normark, Staffan, Winblad, Bengt
The effects of therapeutic concentrations of ampicillin on non-β-lactamase and β-lactamase producing strains of Neisserla gonorrhoeae were studied. A small but significant fraction of bacteria in a...
Cingulate cortex hypoperfusion predicts Alzheimer's disease in mild cognitive impairment
Huang, Chaorui, Wahlund, Lars-Olof, Svensson, Leif, Winblad, Bengt, Julin, Per
Anttila, Tiia, Helkala, Eeva-Liisa, Viitanen, Matti, Kåreholt, Ingemar, Fratiglioni, Laura, Winblad, Bengt, ...
Objective To evaluate the relation between midlife alcohol consumption and mild cognitive impairment and dementia in old age, and the possible modification of this relation by apolipoprotein E.
Nagasaka, Yosuke, Dillner, Karin, Ebise, Hayao, Teramoto, Reiji, Nakagawa, Hiroyuki, Lilius, Lena, ...
Alzheimer's disease (AD) is a neurodegenerative disease with an insidious onset and progressive course that inevitably leads to death. The current diagnostic tools do not allow for diagnosis until...
Cingulate cortex hypoperfusion predicts Alzheimer's disease in mild cognitive impairment
Huang, Chaorui, Wahlund, Lars-Olof, Svensson, Leif, Winblad, Bengt, Julin, Per
Anttila, Tiia, Helkala, Eeva-Liisa, Viitanen, Matti, Kåreholt, Ingemar, Fratiglioni, Laura, Winblad, Bengt, ...
Objective To evaluate the relation between midlife alcohol consumption and mild cognitive impairment and dementia in old age, and the possible modification of this relation by apolipoprotein E.
Nagasaka, Yosuke, Dillner, Karin, Ebise, Hayao, Teramoto, Reiji, Nakagawa, Hiroyuki, Lilius, Lena, ...
Alzheimer's disease (AD) is a neurodegenerative disease with an insidious onset and progressive course that inevitably leads to death. The current diagnostic tools do not allow for diagnosis until...
An, Wen-Lin, Cowburn, Richard F., Li, Lin, Braak, Heiko, Alafuzoff, Irina, Iqbal, Khalid, ...
The ribosomal S6 protein kinase p70 S6 kinase is known for its role in modulating cell-cycle progression, cell size, and cell survival. In response to mitogen stimulation, p70 S6 kinase activation...
Pei, Jin-Jing, Gong, Cheng-Xin, An, Wen-Lin, Winblad, Bengt, Cowburn, Richard F., Grundke-Iqbal, Inge, ...
In Alzheimer’s disease (AD) brain the activity of protein phosphatase (PP)-2A is compromised and that of the extracellular signal-regulated protein kinase (ERK1/2) of the mitogen-activated protein...
Assessment of Health Economics in Alzheimer's Disease (AHEAD): Treatment with Galantamine in Sweden
Frances B. Garfield, Denis Getsios, J. Jaime Caro, Anders Wimo, Bengt Winblad
Background: Like other developed countries with aging populations, Sweden is expecting large increases in the prevalence of Alzheimer's disease and corresponding escalations in the cost of care for...
Anders Wimo, Bengt Winblad, Albrecht Stoffler, Yvonne Wirth, Hansjorg Mobius
Background: Alzheimer's disease (AD) is a devastating illness that causes enormous emotional stress to affected families and is associated with substantial medical and nonmedical costs. Objective: To...
Costs of Mini Mental State Examination-Related Cognitive Impairment
Linus Jonsson, Peter Lindgren, Anders Wimo, Bengt Jonsson, Bengt Winblad
Objective: To investigate the relationship between cognitive impairment, measured with the Mini Mental State Examination (MMSE), and the cost of care. Design: The study uses data from the Kungsholmen...
Hansson Petersen, Camilla A., Alikhani, Nyosha, Behbahani, Homira, Wiehager, Birgitta, Pavlov, Pavel F., Alafuzoff, Irina, ...
The amyloid β-peptide (Aβ) has been suggested to exert its toxicity intracellularly. Mitochondrial functions can be negatively affected by Aβ and accumulation of Aβ has been detected in...
Håkansson, Krister, Rovio, Suvi, Helkala, Eeva-Liisa, Vilska, Anna-Riitta, Winblad, Bengt, Soininen, Hilkka, ...
Objectives To evaluate whether mid-life marital status is related to cognitive function in later life.