The distribution of maxima of approximately Gaussian random fields (2007)
Nardi, Yuval, Siegmund, David O., Yakir, Benjamin
Motivated by the problem of testing for the existence of a signal of known parametric structure and unknown ``location'' (as explained below) against a noisy background, we obtain for the maximum of...
Siegmund, David O, Yakir, Benjamin
In a hidden Markov model, one "estimates" the state of the hidden Markov chain at t by computing via the forwards-backwards algorithm the conditional distribution of the state vector given the...
Siegmund, David O, Yakir, Benjamin
In a hidden Markov model, one "estimates" the state of the hidden Markov chain at t by computing via the forwards-backwards algorithm the conditional distribution of the state vector given the...
Siegmund, David O, Yakir, Benjamin
In a hidden Markov model, one "estimates" the state of the hidden Markov chain at t by computing via the forwards-backwards algorithm the conditional distribution of the state vector given the...
Siegmund, David O, Yakir, Benjamin
In a hidden Markov model, one "estimates" the state of the hidden Markov chain at t by computing via the forwards-backwards algorithm the conditional distribution of the state vector given the...
An Urn Model of Diaconis (2004)
Siegmund, David, Yakir, Benjamin
An urn model of Diaconis and some generalizations are discussed. A convergence theorem is proved that implies for Diaconis' model that the empirical distribution of balls in the urn converges with...
Grossmann,Steffen, Yakir,Benjamin
We examine the distribution of the global maximum of an independent superadditive process with negative drift. We show that, under certain conditions, the distribution’s upper tail decays...
Grossmann, Steffen, Yakir, Benjamin
We examine the distribution of the global maximum of an independent superadditive process with negative drift. We show that, under certain conditions, the distribution's upper tail decays...
Grossmann, Steffen, Yakir, Benjamin
We examine the distribution of the global maximum of an independent superadditive process with negative drift. We show that, under certain conditions, the distribution’s upper tail decays...
Inference about a secondary process following a sequential trial (2003)
We consider the following sequential testing problem. A group‐sequential or fully‐sequential test is carried out for a primary parameter, using a score process or an effective score...
Linkage disequilibrium patterns of the human genome across populations (2003)
Shifman, Sagiv, Kuypers, Jane, Kokoris, Mark, Yakir, Benjamin, Darvasi, Ariel
We studied the patterns of linkage disequilibrium (LD) in the human genome among three populations: African Americans, Caucasians and Ashkenazi Jews. These three populations represent admixed,...
An efficient haplotyping method with DNA pools (2002)
Inbar, Ester, Yakir, Benjamin, Darvasi, Ariel
Determination of haplotype frequencies (the joint distribution of genetic markers) in large population samples is a powerful tool for association studies. This is due to their greater extent of...
Approximate $p$-values for local sequence alignments (2000)
Siegmund, David, Yakir, Benjamin
Assume that two sequences from a finite alphabet are optimally aligned according to a scoring system that rewards similarities according to a general scoring scheme and penalizes gaps (insertions and...
Tail probabilities for the null distribution of scanning statistics (2000)
Siegmund, David, Yakir, Benjamin
This paper is concerned with statistics that scan a multidimensional spatial region to detect a signal against a noisy background. The background is modelled as independent observations from an...
Detecting a change in regression: first-order optimality (1999)
Krieger, Abba M., Pollak, Moshe, Yakir, Benjamin
Observations are generated according to a regression with normal error as a function of time,when the process is in control. The process potentially changes at some unknown point oftime and then the...
Pollak, Moshe, Yakir, Benjamin
The probability that a stochastic process with negative drift exceed a value a often has a renewal-theoretic approximation as $a \to \infty$. Except for a process of iid random variables, this...
Surveillance can be based, in some change-point detection problems, on a sequence of invariant statistics. Gordon and Pollak prove that, under certain conditions, the average run length (ARL) to...
A note on optimal detection of a change in distribution (1997)
Suppose $X_1, X_2, \dots, X_{\nu - 1}$ are iid random variables with distribution $F_0$, and $X_{\nu}, X_{\nu + 1}, \dots$ are are iid with distributed $F_1$. The change point $\nu$ is unknown. The...
We show that if dynamic sampling is feasible, then there exist surveillance schemes that satisfy a probability constraint on false alarm. Procedures are suggested for detecting a change of a normal...
An inequality that relates the probability of false alarm of a change-point detection policy to its average run length to detection is proved. By means of this inequality, a lower bound on the rate...
An efficient haplotyping method with DNA pools
Inbar, Ester, Yakir, Benjamin, Darvasi, Ariel
Determination of haplotype frequencies (the joint distribution of genetic markers) in large population samples is a powerful tool for association studies. This is due to their greater extent of...
An efficient haplotyping method with DNA pools
Inbar, Ester, Yakir, Benjamin, Darvasi, Ariel
Determination of haplotype frequencies (the joint distribution of genetic markers) in large population samples is a powerful tool for association studies. This is due to their greater extent of...
A Highly Significant Association between a COMT Haplotype and Schizophrenia
Shifman, Sagiv, Bronstein, Michal, Sternfeld, Meira, Pisanté-Shalom, Anne, Lev-Lehman, Efrat, Weizman, Avraham, ...
Several lines of evidence have placed the catechol-O-methyltransferase (COMT) gene in the limelight as a candidate gene for schizophrenia. One of these is its biochemical function in metabolism of...
Approximating the Variance of the Conditional Probability of the State of a Hidden Markov Model
David Siegmund, Benjamin Yakir
In a hidden Markov model, one "estimates" the state of the hidden Markov chain at t by computing via the forwards-backwards algorithm the conditional distribution of the state vector given the...
A unified framework for linkage and association analysis of quantitative traits
Dupuis, Josée, Siegmund, David O., Yakir, Benjamin
We give a unified treatment of the statistical foundations of population based association mapping and of family based linkage mapping of quantitative traits in humans. A central ingredient in the...