Bernhard Korn

Letter Identification and Classification of Differentially Expressed Genes in Renal Cell Carcinoma by Expression Profiling on a Global Human 31,500-Element cDNA Array (2008)

Judith M. Boer, Wolfgang K. Huber, Holger Sültmann, Friederike Wilmer, Anja Von Heydebreck, Stefan Haas, ...

We investigated the changes in gene expression accompanying the development and progression of kidney cancer by use of 31,500-element complementary DNA arrays. We measured expression profiles for...

A systematic approach for testing expression of human full-length proteins in cell-free expression systems (2007)

Langlais, Claudia, Guilleaume, Birgit, Wermke, Nadja, Scheuermann, Tina, Ebert, Lars, LaBaer, Joshua, ...

Abstract Background The growing field of proteomics and systems biology is resulting in an ever increasing demand for purified recombinant proteins for structural and functional studies. Here, we...

Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation (2007)

Jakobs, Astrid, Himstedt, Fabian, Funk, Martin, Korn, Bernhard, Gaestel, Matthias, Niedenthal, Rainer

Constitutive and induced protein SUMOylation is involved in the regulation of a variety of cellular processes, such as regulation of gene expression and protein transport, and proceeds mainly in the...

ProteomeBinders: planning a European resource of affinity reagents for analysis of the human proteome (2007)

Taussig, Michael J., Stoevesandt, Oda, Bradbury, Andrew R., Cahill, Dolores, Cambillau, Christian, ...

ProteomeBinders is a new European consortium aiming to establish a comprehensive resource of well-characterized affinity reagents, including but not limited to antibodies, for analysis of the human...

Mouse protein arrays from a TH1 cell cDNA library for antibody screening and serum profiling (2005)

Gutjahr, Claudia, Murphy, Derek, Lueking, Angelika, Koenig, Andrea, Janitz, Michal, O'Brien, John, ...

The mouse is the premier genetic model organism for the study of disease and development. We describe the establishment of a mouse T helper cell type 1 (TH1) protein expression library that provides...

A human protein-protein interaction network : a resource for annotating the proteome (2005)

Stelzl, Ulrich, Worm, Uwe, Lalowski, Maciej, Haenig, Christian, Brembeck, Felix H., Goehler, Heike, ...

Protein-protein interaction maps provide a valuable framework for a better understanding of the functional organization of the proteome. To detect interacting pairs of human proteins systematically,...

Strengths and weaknesses of EST-based prediction of tissue-specific alternative splicing (2004)

Gupta, Shobhit, Zink, Dorothea, Korn, Bernhard, Vingron, Martin, Haas, Stefan A

Abstract Background Alternative splicing contributes significantly to the complexity of the human transcriptome and proteome. Computational prediction of alternative splice isoforms are usually based...

Strengths and weaknesses of EST-based prediction of tissue-specific alternative splicing (2004)

Gupta,Shobhit, Zink,Dorothea, Korn,Bernhard, Vingron,Martin, Haas,Stefan A

Background: Alternative splicing contributes significantly to the complexity of the human transcriptome and proteome. Computational prediction of alternative splice isoforms are usually based on EST...

Integrative Annotation of 21,037 Human Genes Validated by Full-Length cDNA Clones (2004)

Tadashi Imanishi, Takeshi Itoh, Yutaka Suzuki, Claire O'Donovan, Satoshi Fukuchi, Kanako O. Koyanagi, ...

An international team has systematically validated and annotated just over 21,000 human genes using full-length cDNA, thereby providing a valuable new resource for the human genetics community.

Integrative Annotation of 21,037 Human Genes Validated by Full-Length cDNA Clones (2004)

Tadashi Imanishi, Takeshi Itoh, Yutaka Suzuki, Claire O'Donovan, Satoshi Fukuchi, Kanako O. Koyanagi, ...

The human genome sequence defines our inherent biological potential; the realization of the biology encoded therein requires knowledge of the function of each gene. Currently, our knowledge in this...

Strengths and weaknesses of EST-based prediction of tissue-specific alternative splicing (2004)

Gupta, Shobhit, Zink, Dorothea, Korn, Bernhard, Vingron, Martin, Haas, Stefan A

Background: Alternative splicing contributes significantly to the complexity of the human transcriptome and proteome. Computational prediction of alternative splice isoforms are usually based on EST...

Analysis of CREM-dependent gene expression during mouse spermatogenesis (2003)

Beißbarth,Tim, Borisevich,Igor, Hörlein,Andreas, Kenzelmann,Marc, Hergenhahn,Manfred, Klewe-Nebenius,Annette, ...

The transcription factors CREM, CREB, and ATF-1 constitute a subfamily of -Zip transcription factors. Several different kinase cascades regulate the activity of these proteins. The activator...

Analysis of CREM-dependent gene expression during mouse spermatogenesis (2003)

Beißbarth, Tim, Borisevich, Igor, Hörlein, Andreas, Kenzelmann, Marc, Hergenhahn, Manfred, Klewe-Nebenius, Annette, ...

The transcription factors CREM, CREB, and ATF-1 constitute a subfamily of -Zip transcription factors. Several different kinase cascades regulate the activity of these proteins. The activator...

The DT40 web site: sampling and connecting the genes of a B cell line (2002)

Buerstedde, Jean-Marie, Arakawa, Hiroshi, Watahiki, Akira, Carninci, Piere Piero, Hayashizaki, Y. Yoshihide, Korn, Bernhard, ...

Thousands of new vertebrate genes have been discovered and genetic systems are needed to address their functions at the cellular level. The chicken B cell line DT40 allows efficient gene disruptions...

Expression patterns of two human genes coding for different rab GDP-dissociation inhibitors (GDIs), extremely conserved proteins involved in cellular transport (1995)

Bächner, Dietmar, Sedlacek, Zdenek, Korn, Bernhard, Hameister, Horst, Poustka, Annemarie

We have analysed the expression patterns of two human genes coding for two different rab GDIs, rab GDI α/XAP-4 and rab GDI β, proteins involved in the regulation of vesicle-mediated cellular...

Model for a transcript map of human chromosome 21: isolation of new coding sequences from exon and enriched cDNA libraries (1995)

Yaspo, Marie-Laure, Gellen, Lisa, Mott, Richard, Korn, Bernhard, Nizetic, Dean, Poustka, AnneMarie, ...

The construction of a transcriptional map for human chromosome 21 requires the generation of a specific catalogue of genes, together with corresponding mapping information. Towards this goal, we...

The detailed characterisation of a 400 kb cosmid walk in the BRCA1 region: identification and localisation of 10 genes including a dual-specificity phosphatase (1994)

A.Jones, Karen, M.Black, Donald, A.Brown, Melissa, L.Griffiths, Beatrice, M.Nicolai, Hans, A.Chambers, Julie, ...

We have produced a detailed physical and transcriptional map of a 400 kb region within the narrowest flanking markers known to contain the hereditary breast and ovarian susceptibility gene, BRCA1....

construction of a transcription map of a 300 kb region around the human G6PD locus by direst cDNA selection (1993)

Sediacek, Zdenek, Korn, Bernhard, Konecki, David S., Siebenhaar, Renate, Coy, Johannes F., Kioschis, Petra, ...

A transcription map covering a 300 kb region around the G6PD gene in the human Xq28 region was constructed by the direct cDNA selection method and the analysis of the resulting region-specific...

A strategy for the selection of transcribed sequences in the Xq28 region (1992)

Korn, Bernhard, Sedlacek, Zdenek, Manca, Antonella, Kioschis, Petra, Konecki, David, Lehrach, Hans, ...

As an essential step towards an exhaustive analysis of the coding potential of large regions of the genome, we have developed a protocol allowing the rapid isolation of transcripts defmed by...

Molecular cloning and analysis of the fragile X region in man (1991)

Dietrich, Alexander, Kioschis, Petra, Monaco, Anthony P., Gross, Baerbel, Korn, Bernhard, Williams, Sarah V., ...

The fragile X syndrome (FraX), the most common Inherited form of mental retardation, has been located to Xq27.3. As a step In the molecular analysis of this mutation, we have cloned a contiguous 1.8...

The DT40 web site: sampling and connecting the genes of a B cell line

Buerstedde, Jean-Marie, Arakawa, Hiroshi, Watahiki, Akira, Carninci, Piere Piero, Hayashizaki, Y. Yoshihide, Korn, Bernhard, ...

Thousands of new vertebrate genes have been discovered and genetic systems are needed to address their functions at the cellular level. The chicken B cell line DT40 allows efficient gene disruptions...

Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs

Wiemann, Stefan, Weil, Bernd, Wellenreuther, Ruth, Gassenhuber, Johannes, Glassl, Sabine, Ansorge, Wilhelm, ...

With the complete human genomic sequence being unraveled, the focus will shift to gene identification and to the functional analysis of gene products. The generation of a set of cDNAs, both sequences...

Identification and Classification of Differentially Expressed Genes in Renal Cell Carcinoma by Expression Profiling on a Global Human 31,500-Element cDNA Array

Boer, Judith M., Huber, Wolfgang K., Sültmann, Holger, Wilmer, Friederike, Von Heydebreck, Anja, Haas, Stefan, ...

We investigated the changes in gene expression accompanying the development and progression of kidney cancer by use of 31,500-element complementary DNA arrays. We measured expression profiles for...

Integrative Annotation of 21,037 Human Genes Validated by Full-Length cDNA Clones

Imanishi, Tadashi, Itoh, Takeshi, Suzuki, Yutaka, O'Donovan, Claire, Fukuchi, Satoshi, Koyanagi, Kanako O, ...

The human genome sequence defines our inherent biological potential; the realization of the biology encoded therein requires knowledge of the function of each gene. Currently, our knowledge in this...

A microdeletion of less than 250 kb, including the proximal part of the FMR-1 gene and the fragile-X site, in a male with the clinical phenotype of fragile-X syndrome

Wöhrle, Doris, Kotzot, Dieter, Hirst, Mark C., Manca, Antonella, Korn, Bernhard, Schmidt, Angela, ...

A gene designated “FMR-1” has been isolated at the fragile-X locus. One exon of this gene is carried on a 5.1-kb EcoRI fragment that exhibits length variation in fragile-X patients because of...

The DT40 web site: sampling and connecting the genes of a B cell line

Buerstedde, Jean-Marie, Arakawa, Hiroshi, Watahiki, Akira, Carninci, Piere Piero, Hayashizaki, Y. Yoshihide, Korn, Bernhard, ...

Thousands of new vertebrate genes have been discovered and genetic systems are needed to address their functions at the cellular level. The chicken B cell line DT40 allows efficient gene disruptions...

Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs

Wiemann, Stefan, Weil, Bernd, Wellenreuther, Ruth, Gassenhuber, Johannes, Glassl, Sabine, Ansorge, Wilhelm, ...

With the complete human genomic sequence being unraveled, the focus will shift to gene identification and to the functional analysis of gene products. The generation of a set of cDNAs, both sequences...

Identification and Classification of Differentially Expressed Genes in Renal Cell Carcinoma by Expression Profiling on a Global Human 31,500-Element cDNA Array

Boer, Judith M., Huber, Wolfgang K., Sültmann, Holger, Wilmer, Friederike, Von Heydebreck, Anja, Haas, Stefan, ...

We investigated the changes in gene expression accompanying the development and progression of kidney cancer by use of 31,500-element complementary DNA arrays. We measured expression profiles for...

Integrative Annotation of 21,037 Human Genes Validated by Full-Length cDNA Clones

Imanishi, Tadashi, Itoh, Takeshi, Suzuki, Yutaka, O'Donovan, Claire, Fukuchi, Satoshi, Koyanagi, Kanako O, ...

The human genome sequence defines our inherent biological potential; the realization of the biology encoded therein requires knowledge of the function of each gene. Currently, our knowledge in this...

A microdeletion of less than 250 kb, including the proximal part of the FMR-1 gene and the fragile-X site, in a male with the clinical phenotype of fragile-X syndrome

Wöhrle, Doris, Kotzot, Dieter, Hirst, Mark C., Manca, Antonella, Korn, Bernhard, Schmidt, Angela, ...

A gene designated “FMR-1” has been isolated at the fragile-X locus. One exon of this gene is carried on a 5.1-kb EcoRI fragment that exhibits length variation in fragile-X patients because of...

Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation

Jakobs, Astrid, Himstedt, Fabian, Funk, Martin, Korn, Bernhard, Gaestel, Matthias, Niedenthal, Rainer

Constitutive and induced protein SUMOylation is involved in the regulation of a variety of cellular processes, such as regulation of gene expression and protein transport, and proceeds mainly in the...

A Biomedically Enriched Collection of 7000 Human ORF Clones

Rolfs, Andreas, Hu, Yanhui, Ebert, Lars, Hoffmann, Dietmar, Zuo, Dongmei, Ramachandran, Niro, ...

We report the production and availability of over 7000 fully sequence verified plasmid ORF clones representing over 3400 unique human genes. These ORF clones were derived using the human MGC...

Transporter Molecules influence the Gene Expression in HeLa Cells

Waldeck, Waldemar, Pipkorn, Ruediger, Korn, Bernhard, Mueller, Gabriele, Schick, Matthias, Tóth, Katalin, ...

Progresses in biology and pharmacology led to highly specific bioactive substances, but their poor bioavailability at the site of action is a result of their physico-chemical properties. Various...