Park, Hyun-Sook, Östberg, Yngve, Johansson, Jörgen, Wagner, E. Gerhart H., Uhlin, Bernt Eric
In Escherichia coli, the major nucleoid protein H-NS limits transcription by acting as a repressor or transcriptional silencer, presumably by its ability to close the looped chromosome domains in the...
Bmc Microbiology, Barbro Lindmark, Pramod Kumar Rompikuntal, Karolis Vaitkevicius, Tianyan Song, Yoshimitsu Mizunoe, ...
Research article Outer membrane vesicle-mediated release of cytolethal distending toxin (CDT) from Campylobacter jejuni
Pathogenomics: An updated European Research Agenda (2008)
Demuth, Andreas, Aharonowitz, Yair, Bachmann, Till T., Blum-Oehler, Gabriele, Buchrieser, Carmen, Covacci, Antonello, ...
Release of the type I secreted α-haemolysin via outer membrane vesicles from Escherichia coli (2006)
Balsalobre, Carlos, Silván, José Manuel, Berglund, Stina, Mizunoe, Yoshimitsu, Uhlin, Bernt Eric, Nyunt Wai, Sun
The α-haemolysin is an important virulence factor commonly expressed by extraintestinal pathogenic Escherichia coli. The secretion of the α-haemolysin is mediated by the type I secretion system and...
Physical Properties of Escherichia coli P Pili Measured by Optical Tweezers (2004)
Jass, Jana, Schedin, Staffan, Fällman, Erik, Ohlsson, Jörgen, Nilsson, Ulf J, Uhlin, Bernt Eric, ...
The mechanical behavior of individual P pili of uropathogenic Escherichia coli has been investigated using optical tweezers. P pili, whose main part constitutes the PapA rod, composed of 103 PapA...
Transcriptional silencing and thermoregulation of gene expression in Escherichia coli (1990)
Mikael Göransson, Berit Sondén, Peter Nilsson, Björn Dagberg, Kristina Foreman, Karin Emanuelsson, ...
Johansson, Jörgen, Uhlin, Bernt Eric
The Escherichia coli proteins H-NS is recognized as an important component among the major nucleoid-associated proteins. In studies of E. coli strains with defects in H-NS, we discovered a mutant...
Balsalobre, Carlos, Johansson, Jörgen, Uhlin, Bernt Eric, Juárez, Antonio, Muñoa, Francisco J.
The Hha protein belongs to a new family of regulators involved in the environmental regulation of virulence factors. The aim of this work was to study the effect of the hha mutation on the overall...
Silencing and Activation of ClyA Cytotoxin Expression in Escherichia coli
Westermark, Marie, Oscarsson, Jan, Mizunoe, Yoshimitsu, Urbonaviciene, Jurate, Uhlin, Bernt Eric
Cytolysin A (ClyA) is a pore-forming cytotoxic protein encoded by the clyA gene of Escherichia coli K-12. Genetic analysis suggested that clyA is silenced by the nucleoid protein H-NS. Purified H-NS...
Johansson, Jörgen, Eriksson, Sven, Sondén, Berit, Wai, Sun Nyunt, Uhlin, Bernt Eric
The nucleoid-associated proteins H-NS and StpA in Escherichia coli bind DNA as oligomers and are implicated in gene regulatory systems. There is evidence for both homomeric and heteromeric...
Lai, Xin-He, Arencibia, Ignacio, Johansson, Anders, Wai, Sun Nyunt, Oscarsson, Jan, Kalfas, Sotos, ...
Cytolysin A (ClyA) is a newly discovered cytolytic protein of Escherichia coli K-12 that mediates a hemolytic phenotype. We show here that highly purified ClyA and ClyA-expressing E. coli were...
H-NS and StpA Proteins Stimulate Expression of the Maltose Regulon in Escherichia coli
Johansson, Jörgen, Dagberg, Björn, Richet, Evelyne, Uhlin, Bernt Eric
The nucleoid-associated protein H-NS is a major component of the chromosome-protein complex, and it is known to influence the regulation of many genes in Escherichia coli. Its role in gene regulation...
Oscarsson, Jan, Westermark, Marie, Löfdahl, Sven, Olsen, Björn, Palmgren, Helena, Mizunoe, Yoshimitsu, ...
Cytolysin A (ClyA) is a pore-forming cytotoxic protein encoded by the clyA gene that has been characterized so far only in Escherichia coli. Using DNA sequence analysis and PCR, we established that...
Balsalobre, Carlos, Morschhäuser, Joachim, Jass, Jana, Hacker, Jörg, Uhlin, Bernt Eric
Among the virulence factors present in pathogenic extraintestinal Escherichia coli strains, expression of fimbrial adhesins is necessary for attachment to the host tissues and subsequent...
Characterization of Dominantly Negative Mutant ClyA Cytotoxin Proteins in Escherichia coli
Wai, Sun Nyunt, Westermark, Marie, Oscarsson , Jan, Jass , Jana, Maier, Elke, Benz, Roland, ...
We report studies of the subcellular localization of the ClyA cytotoxic protein and of mutations causing defective translocation to the periplasm in Escherichia coli. The ability of ClyA to...
Xia, Yan, Gally, David, Forsman-Semb, Kristina, Uhlin, Bernt Eric
Pathogenic Escherichia coli often carry determinants for several different adhesins. We show a direct communication between two adhesin gene clusters in uropathogenic E.coli: type 1 fimbriae (fim)...
Physical Properties of Escherichia coli P Pili Measured by Optical Tweezers
Jass, Jana, Schedin, Staffan, Fällman, Erik, Ohlsson, Jörgen, Nilsson, Ulf J., Uhlin, Bernt Eric, ...
The mechanical behavior of individual P pili of uropathogenic Escherichia coli has been investigated using optical tweezers. P pili, whose main part constitutes the PapA rod, composed of ∼103 PapA...
Kouokam, J. Clavin, Wai, Sun Nyunt, Fällman, Maria, Dobrindt, Ulrich, Hacker, Jörg, Uhlin, Bernt Eric
Cytotoxic necrotizing factor type 1 (CNF1) is one of the virulence factors produced by uropathogenic Escherichia coli (UPEC). How this toxin is translocated from the bacterial cytoplasm to the...
Müller, Claudia M., Dobrindt, Ulrich, Nagy, Gábor, Emödy, Levente, Uhlin, Bernt Eric, Hacker, Jörg
The histone-like protein H-NS is a global regulator in Escherichia coli that has been intensively studied in nonpathogenic strains. However, no comprehensive study on the role of H-NS and its...
Cyclic AMP-Dependent Osmoregulation of crp Gene Expression in Escherichia coli
Balsalobre, Carlos, Johansson, Jörgen, Uhlin, Bernt Eric
We have found that the cyclic AMP (cAMP) receptor protein (CRP)-cAMP regulatory complex in Escherichia coli is subject to osmoregulation at the level of crp gene expression. This osmoregulation was...
Johansson, Jörgen, Uhlin, Bernt Eric
The Escherichia coli proteins H-NS is recognized as an important component among the major nucleoid-associated proteins. In studies of E. coli strains with defects in H-NS, we discovered a mutant...
Balsalobre, Carlos, Johansson, Jörgen, Uhlin, Bernt Eric, Juárez, Antonio, Muñoa, Francisco J.
The Hha protein belongs to a new family of regulators involved in the environmental regulation of virulence factors. The aim of this work was to study the effect of the hha mutation on the overall...
Silencing and Activation of ClyA Cytotoxin Expression in Escherichia coli
Westermark, Marie, Oscarsson, Jan, Mizunoe, Yoshimitsu, Urbonaviciene, Jurate, Uhlin, Bernt Eric
Cytolysin A (ClyA) is a pore-forming cytotoxic protein encoded by the clyA gene of Escherichia coli K-12. Genetic analysis suggested that clyA is silenced by the nucleoid protein H-NS. Purified H-NS...
Johansson, Jörgen, Eriksson, Sven, Sondén, Berit, Wai, Sun Nyunt, Uhlin, Bernt Eric
The nucleoid-associated proteins H-NS and StpA in Escherichia coli bind DNA as oligomers and are implicated in gene regulatory systems. There is evidence for both homomeric and heteromeric...
Lai, Xin-He, Arencibia, Ignacio, Johansson, Anders, Wai, Sun Nyunt, Oscarsson, Jan, Kalfas, Sotos, ...
Cytolysin A (ClyA) is a newly discovered cytolytic protein of Escherichia coli K-12 that mediates a hemolytic phenotype. We show here that highly purified ClyA and ClyA-expressing E. coli were...
H-NS and StpA Proteins Stimulate Expression of the Maltose Regulon in Escherichia coli
Johansson, Jörgen, Dagberg, Björn, Richet, Evelyne, Uhlin, Bernt Eric
The nucleoid-associated protein H-NS is a major component of the chromosome-protein complex, and it is known to influence the regulation of many genes in Escherichia coli. Its role in gene regulation...
Oscarsson, Jan, Westermark, Marie, Löfdahl, Sven, Olsen, Björn, Palmgren, Helena, Mizunoe, Yoshimitsu, ...
Cytolysin A (ClyA) is a pore-forming cytotoxic protein encoded by the clyA gene that has been characterized so far only in Escherichia coli. Using DNA sequence analysis and PCR, we established that...
Balsalobre, Carlos, Morschhäuser, Joachim, Jass, Jana, Hacker, Jörg, Uhlin, Bernt Eric
Among the virulence factors present in pathogenic extraintestinal Escherichia coli strains, expression of fimbrial adhesins is necessary for attachment to the host tissues and subsequent...
Characterization of Dominantly Negative Mutant ClyA Cytotoxin Proteins in Escherichia coli
Wai, Sun Nyunt, Westermark, Marie, Oscarsson , Jan, Jass , Jana, Maier, Elke, Benz, Roland, ...
We report studies of the subcellular localization of the ClyA cytotoxic protein and of mutations causing defective translocation to the periplasm in Escherichia coli. The ability of ClyA to...
Xia, Yan, Gally, David, Forsman-Semb, Kristina, Uhlin, Bernt Eric
Pathogenic Escherichia coli often carry determinants for several different adhesins. We show a direct communication between two adhesin gene clusters in uropathogenic E.coli: type 1 fimbriae (fim)...
Physical Properties of Escherichia coli P Pili Measured by Optical Tweezers
Jass, Jana, Schedin, Staffan, Fällman, Erik, Ohlsson, Jörgen, Nilsson, Ulf J., Uhlin, Bernt Eric, ...
The mechanical behavior of individual P pili of uropathogenic Escherichia coli has been investigated using optical tweezers. P pili, whose main part constitutes the PapA rod, composed of ∼103 PapA...
Kouokam, J. Clavin, Wai, Sun Nyunt, Fällman, Maria, Dobrindt, Ulrich, Hacker, Jörg, Uhlin, Bernt Eric
Cytotoxic necrotizing factor type 1 (CNF1) is one of the virulence factors produced by uropathogenic Escherichia coli (UPEC). How this toxin is translocated from the bacterial cytoplasm to the...
Müller, Claudia M., Dobrindt, Ulrich, Nagy, Gábor, Emödy, Levente, Uhlin, Bernt Eric, Hacker, Jörg
The histone-like protein H-NS is a global regulator in Escherichia coli that has been intensively studied in nonpathogenic strains. However, no comprehensive study on the role of H-NS and its...
Cyclic AMP-Dependent Osmoregulation of crp Gene Expression in Escherichia coli
Balsalobre, Carlos, Johansson, Jörgen, Uhlin, Bernt Eric
We have found that the cyclic AMP (cAMP) receptor protein (CRP)-cAMP regulatory complex in Escherichia coli is subject to osmoregulation at the level of crp gene expression. This osmoregulation was...
A Sticky Chain Model of the Elongation and Unfolding of Escherichia coli P Pili under Stress
Andersson, Magnus, Fällman, Erik, Uhlin, Bernt Eric, Axner, Ove
A model of the elongation of P pili expressed by uropathogenic Escherichia coli exposed to stress is presented. The model is based upon the sticky chain concept, which is based upon Hooke's law for...
Dynamic Force Spectroscopy of E. coli P Pili
Andersson, Magnus, Fällman, Erik, Uhlin, Bernt Eric, Axner, Ove
Surface organelles (so-called pili) expressed on the bacterial membrane mediate the adhesion of Escherichia coli causing urinary tract infection. These pili possess some extraordinary elongation...
Regulatory Interactions among Adhesin Gene Systems of Uropathogenic Escherichia coli▿
Lindberg, Stina, Xia, Yan, Sondén, Berit, Göransson, Mikael, Hacker, Jörg, Uhlin, Bernt Eric
Uropathogenic Escherichia coli strain J96 carries multiple determinants for fimbrial adhesins. The regulatory protein PapB of P fimbriae has previously been implicated in potential coregulatory...
Galka, Frank, Wai, Sun Nyunt, Kusch, Harald, Engelmann, Susanne, Hecker, Michael, Schmeck, Bernd, ...
Secretion of effector molecules is one of the major mechanisms by which the intracellular human pathogen Legionella pneumophila interacts with host cells during infection. Specific secretion...
Andersson, Magnus, Uhlin, Bernt Eric, Fällman, Erik
Uropathogenic Escherichia coli express pili that mediate binding to host tissue cells. We demonstrate with in situ force measuring optical tweezers that the ability of P and type 1 pili to elongate...
Müller, Claudia M., Åberg, Anna, Straseviçiene, Jurate, Emődy, Levente, Uhlin, Bernt Eric, Balsalobre, Carlos
Type 1 fimbriae are a crucial factor for the virulence of uropathogenic Escherichia coli during the first steps of infection by mediating adhesion to epithelial cells. They are also required for the...
Lindmark, Barbro, Rompikuntal, Pramod Kumar, Vaitkevicius, Karolis, Song, Tianyan, Mizunoe, Yoshimitsu, Uhlin, Bernt Eric, ...
Müller, Claudia M, Schneider, György, Dobrindt, Ulrich, Emödy, Levente, Hacker, Jörg, Uhlin, Bernt Eric
The nucleoid-associated protein H-NS is important for gene regulation in Escherichia coli. We have studied H-NS interaction with StpA and an uncharacterized H-NS-like protein, Hfp, in the...