Bert Zomer

Two variants among Haemophilus influenzaeserotype b strains with distinct bcs4, hcsAand hcsBgenes display differences in expression of the polysaccharide capsule (2008)

Schouls, Leo, Van Der Heide, Han, Witteveen, Sandra, Zomer, Bert, Van Der Ende, Arie, Burger, Marina, ...

Abstract Background Despite nearly complete vaccine coverage, a small number of fully vaccinated children in the Netherlands have experienced invasive disease caused by Haemophilus influenzae...

Modeling Neisseria meningitidismetabolism: from genome to metabolic fluxes (2007)

Baart, Gino JE, Zomer, Bert, De Haan, Alex, Van Der Pol, Leo A, Beuvery, E Coen, Tramper, Johannes, ...

Abstract Background Neisseria meningitidis is a human pathogen that can infect diverse sites within the human host. The major diseases caused by N. meningitidis are responsible for death and...

Modification of Lipid A Biosynthesis in Neisseria meningitidis lpxL Mutants: Influence on Lipopolysaccharide Structure, Toxicity, and Adjuvant Activity

Van Der Ley, Peter, Steeghs, Liana, Hamstra, Hendrik Jan, Ten Hove, Jan, Zomer, Bert, Van Alphen, Loek

Two genes homologous to lpxL and lpxM from Escherichia coli and other gram-negative bacteria, which are involved in lipid A acyloxyacylation, were identified in Neisseria meningitidis strain H44/76...

Outer membrane composition of a lipopolysaccharide-deficient Neisseria meningitidis mutant

Steeghs, Liana, Cock, Hans De, Evers, Evert, Zomer, Bert, Tommassen, Jan, Ley, Peter Van Der

In the pathogen Neisseria meningitidis, a completely lipopolysaccharide (LPS)-deficient but viable mutant can be obtained by insertional inactivation of the lpxA gene, encoding UDP-GlcNAc...

Modification of Lipid A Biosynthesis in Neisseria meningitidis lpxL Mutants: Influence on Lipopolysaccharide Structure, Toxicity, and Adjuvant Activity

Van Der Ley, Peter, Steeghs, Liana, Hamstra, Hendrik Jan, Ten Hove, Jan, Zomer, Bert, Van Alphen, Loek

Two genes homologous to lpxL and lpxM from Escherichia coli and other gram-negative bacteria, which are involved in lipid A acyloxyacylation, were identified in Neisseria meningitidis strain H44/76...

Outer membrane composition of a lipopolysaccharide-deficient Neisseria meningitidis mutant

Steeghs, Liana, Cock, Hans De, Evers, Evert, Zomer, Bert, Tommassen, Jan, Ley, Peter Van Der

In the pathogen Neisseria meningitidis, a completely lipopolysaccharide (LPS)-deficient but viable mutant can be obtained by insertional inactivation of the lpxA gene, encoding UDP-GlcNAc...

Modeling Neisseria meningitidis metabolism: from genome to metabolic fluxes

Baart, Gino JE, Zomer, Bert, De Haan, Alex, Van Der Pol, Leo A, Beuvery, E Coen, Tramper, Johannes, ...

A genome-scale flux model for primary metabolism of Neisseria meningitidis was constructed; a minimal medium for growth of N. meningitidis was designed using the model and tested successfully in...