Bettina Kulle

GSEA-SNP: applying gene set enrichment analysis to SNP data from genome-wide association studies (2008)

Holden, Marit, Deng, Shiwei, Wojnowski, Leszek, Kulle, Bettina

The power of genome-wide SNP association studies is limited, among others, by the large number of false positive test results. To provide a remedy, we combined SNP association analysis with the...

Surrogate phenotype definition for alcohol use disorders: a genome-wide search for linkage and association (2005)

Rosenberger, Albert, Janicke, Nico, Köhler, Karola, Korb, Katrin, Kulle, Bettina, Bickeböller, Heike

Abstract For the identification of susceptibility loci in complex diseases the choice of the target phenotype is very important. We compared results of genome-wide searches for linkage or for...

NAD(P)H oxidase and multidrug resistance protein genetic polymorphisms are associated with doxorubicin-induced cardiotoxicity (2005)

Wojnowski, Leszek, Kulle, Bettina, Schirmer, Markus, Schlüter, Gregor, Schmidt, Albrecht, Rosenberger, Albert, ...

Background: A significant number of patients treated with anthracyclines develop cardiotoxicity (anthracycline-induced cardiotoxicity [ACT]), mainly presenting as arrhythmias (acute ACT) or...

Equivalence test in quantitative reverse transcription polymerase chain reaction: confirmation of reference genes suitable for normalization (2004)

Haller,Florian, Kulle,Bettina, Schwager,Stefanie, Gunawan,Bastian, Von Heydebreck,Anja, Sültmann,Holger, ...

In quantitative reverse transcription–polymerase chain reaction (qRT–PCR), normalization using reference genes is a common useful approach, but the validation of suitable reference genes remains...

Equivalence test in quantitative reverse transcription polymerase chain reaction: confirmation of reference genes suitable for normalization (2004)

Haller, Florian, Kulle, Bettina, Schwager, Stefanie, Gunawan, Bastian, Von Heydebreck, Anja, Sültmann, Holger, ...

In quantitative reverse transcription–polymerase chain reaction (qRT–PCR), normalization using reference genes is a common useful approach, but the validation of suitable reference genes remains...

Nonparametric longitudinal allele-sharing model (2003)

Kulle, Bettina, Köhler, Karola, Rosenberger, Albert, Loesgen, Sabine, Bickeböller, Heike

Abstract Basically no methods are available for the analysis of quantitative traits in longitudinal genetic epidemiological studies. We introduce a nonparametric factorial design for longitudinal...

Nichtparametrische Cross-Over-Verfahren (2001)

Kulle, Bettina

In a standard cross-over design there are two groups, which differ with respect to the order, in which two treatments are applied. In the past, statistical methods for this design were based on the...

Nonparametric longitudinal allele-sharing model

Kulle, Bettina, Köhler, Karola, Rosenberger, Albert, Loesgen, Sabine, Bickeböller, Heike

Basically no methods are available for the analysis of quantitative traits in longitudinal genetic epidemiological studies. We introduce a nonparametric factorial design for longitudinal data on...