Bettina Tilton

Signal Transduction by Cxc Chemokine Receptor 4: Stromal Cell–Derived Factor 1 Stimulates Prolonged Protein Kinase B and Extracellular Signal–Regulated Kinase 2 Activation in T Lymphocytes

Tilton, Bettina, Ho, Liza, Oberlin, Estelle, Loetscher, Pius, Baleux, Françoise, Clark-Lewis, Ian, ...

We report that stromal cell–derived factor (SDF)-1 has the remarkable capacity to induce sustained signaling through CXC chemokine receptor 4 (CXCR4). In contrast to other chemokines, such as...