Biljana Georgievska

Seizure Suppression by GDNF Gene Therapy in Animal Models of Epilepsy. (2007)

Kanter-Schlifke, Irene, Georgievska, Biljana, Kirik, Deniz, Kokaia, Merab

Abstract is not available

Brain area, age and viral vector-specific glial cell-line-derived neurotrophic factor expression and transport in rat. (2007)

Kanter-Schlifke, Irene, Georgievska, Biljana, Kirik, Deniz, Kokaia, Merab

Abstract is not available

Ex vivo gene delivery of GDNF using primary astrocytes transduced with a lentiviral vector provides neuroprotection in a rat model of Parkinson's disease. (2005)

Ericson, Cecilia, Georgievska, Biljana, Lundberg, Cecilia

Abstract is not available

GDNF gene delivery in an animal model of Parkinson's disease. Long-term effects on intact, injured and transplanted dopamine neurons using lentiviral gene transfer (2004)

Georgievska, Biljana

Parkinson's disease is characterized by a progressive degeneration of dopaminergic neurons in the substantia nigra, leading to a loss of dopamine in the target structure striatum and development of...

Localized striatal delivery of GDNF as a treatment for Parkinson disease. (2004)

Kirik, Deniz, Georgievska, Biljana, Björklund, Anders

Abstract not available.

Lesion-dependent regulation of transgene expression in the rat brain using a human glial fibrillary acidic protein-lentiviral vector. (2004)

Jakobsson, Johan, Georgievska, Biljana, Ericson, Cecilia, Lundberg, Cecilia

The ability to regulate transgene expression will be crucial for development of gene therapy to the brain. The most commonly used systems are based on a transactivator in combination with a drug,...

Overexpression of glial cell line-derived neurotrophic factor using a lentiviral vector induces time- and dose-dependent downregulation of tyrosine hydroxylase in the intact nigrostriatal dopamine system. (2004)

Georgievska, Biljana, Kirik, Deniz, Björklund, Anders

Abstract is not available

Regulated delivery of glial cell line-derived neurotrophic factor into rat striatum, using a tetracycline-dependent lentiviral vector. (2004)

Georgievska, Biljana, Jakobsson, Johan, Persson, Elisabeth, Ericson, Cecilia, Kirik, Deniz, Lundberg, Cecilia

Abstract is not available

Dissociation between short-term increased graft survival and long-term functional improvements in Parkinsonian rats overexpressing glial cell line-derived neurotrophic factor. (2004)

Georgievska, Biljana, Carlsson, Thomas, Lacar, Benjamin, Winkler, Christian, Kirik, Deniz

Abstract is not available

Long-term striatal overexpression of GDNF selectively downregulates tyrosine hydroxylase in the intact nigrostriatal dopamine system. (2003)

Rosenblad, Carl, Georgievska, Biljana, Kirik, Deniz

Sustained neurotrophic factor treatment in neurodegenerative disorders such as Parkinson's disease is likely to affect both degenerating and intact neurons. To investigate the effect of long-term...

Neuroprotection in the rat Parkinson model by intrastriatal GDNF gene transfer using a lentiviral vector. (2002)

Georgievska, Biljana, Kirik, Deniz, Rosenblad, Carl, Lundberg, Cecilia, Björklund, Anders

We used a recombinant lentiviral vector (rLV) for gene delivery of GDNF to the striatum, and assessed its neuroprotective effects in the intrastriatal 6-hydroxydopamine (6-OHDA) lesion model.The...

Reversal of motor impairments in parkinsonian rats by continuous intrastriatal delivery of L-dopa using rAAV-mediated gene transfer. (2002)

Kirik, Deniz, Georgievska, Biljana, Burger, Corinna, Winkler, Christian, Muzyczka, Nicholas, Mandel, Ronald J, ...

Intrastriatal delivery of the tyrosine hydroxylase gene by viral vectors is being explored as a tool for local delivery of L-dopa in animals with lesions of the nigrostriatal pathway. The functional...

Aberrant sprouting and downregulation of tyrosine hydroxylase in lesioned nigrostriatal dopamine neurons induced by long-lasting overexpression of glial cell line derived neurotrophic factor in the striatum by lentiviral gene transfer. (2002)

Georgievska, Biljana, Kirik, Deniz, Björklund, Anders

Abstract is not available

Reversal of motor impairments in parkinsonian rats by continuous intrastriatal delivery of l-dopa using rAAV-mediated gene transfer

Kirik, Deniz, Georgievska, Biljana, Burger, Corinna, Winkler, Christian, Muzyczka, Nicholas, Mandel, Ronald J., ...

Intrastriatal delivery of the tyrosine hydroxylase gene by viral vectors is being explored as a tool for local delivery of l-dopa in animals with lesions of the nigrostriatal pathway. The functional...

Reversal of motor impairments in parkinsonian rats by continuous intrastriatal delivery of l-dopa using rAAV-mediated gene transfer

Kirik, Deniz, Georgievska, Biljana, Burger, Corinna, Winkler, Christian, Muzyczka, Nicholas, Mandel, Ronald J., ...

Intrastriatal delivery of the tyrosine hydroxylase gene by viral vectors is being explored as a tool for local delivery of l-dopa in animals with lesions of the nigrostriatal pathway. The functional...