Submitted to: Dept. of Molecular and Cellular Biology.
Gangliosides are receptors for murine polyoma virus and SV40
Tsai, Billy, Gilbert, Joanna M., Stehle, Thilo, Lencer, Wayne, Benjamin, Thomas L., Rapoport, Tom A.
Polyoma virus (Py) and simian virus 40 (SV40) travel from the plasma membrane to the endoplasmic reticulum (ER) from where they enter the cytosol and then the nucleus to initiate infection. Here we...
Fujinaga, Yukako, Wolf, Anne A., Rodighiero, Chiara, Wheeler, Heidi, Tsai, Billy, Allen, Larry, ...
Cholera toxin (CT) travels from the plasma membrane of intestinal cells to the endoplasmic reticulum (ER) where a portion of the A-subunit, the A1 chain, crosses the membrane into the cytosol to...
Role of ubiquitination in retro-translocation of cholera toxin and escape of cytosolic degradation
Rodighiero, Chiara, Tsai, Billy, Rapoport, Tom A., Lencer, Wayne I.
Cholera toxin travels from the cell surface of affected mammalian cells to the endoplasmic reticulum (ER), where the A1 chain is released and retro-translocated across the ER membrane into the...
Identification of Gangliosides GD1b and GT1b as Receptors for BK Virus
Low, Jonathan A., Magnuson, Brian, Tsai, Billy, Imperiale, Michael J.
Gangliosides have been shown to be plasma membrane receptors for both murine polyomavirus and SV40, while JC virus uses serotonin receptors. In contrast, little is known of the membrane receptor and...
Gangliosides are receptors for murine polyoma virus and SV40
Tsai, Billy, Gilbert, Joanna M., Stehle, Thilo, Lencer, Wayne, Benjamin, Thomas L., Rapoport, Tom A.
Polyoma virus (Py) and simian virus 40 (SV40) travel from the plasma membrane to the endoplasmic reticulum (ER) from where they enter the cytosol and then the nucleus to initiate infection. Here we...
Fujinaga, Yukako, Wolf, Anne A., Rodighiero, Chiara, Wheeler, Heidi, Tsai, Billy, Allen, Larry, ...
Cholera toxin (CT) travels from the plasma membrane of intestinal cells to the endoplasmic reticulum (ER) where a portion of the A-subunit, the A1 chain, crosses the membrane into the cytosol to...
Role of ubiquitination in retro-translocation of cholera toxin and escape of cytosolic degradation
Rodighiero, Chiara, Tsai, Billy, Rapoport, Tom A., Lencer, Wayne I.
Cholera toxin travels from the cell surface of affected mammalian cells to the endoplasmic reticulum (ER), where the A1 chain is released and retro-translocated across the ER membrane into the...
Identification of Gangliosides GD1b and GT1b as Receptors for BK Virus
Low, Jonathan A., Magnuson, Brian, Tsai, Billy, Imperiale, Michael J.
Gangliosides have been shown to be plasma membrane receptors for both murine polyomavirus and SV40, while JC virus uses serotonin receptors. In contrast, little is known of the membrane receptor and...
Dimerization of ERp29, a PDI-like Protein, Is Essential for Its Diverse Functions
Rainey-Barger, Emily K., Mkrtchian, Souren, Tsai, Billy
Protein disulfide isomerase (PDI)-like proteins act as oxido-reductases and chaperones in the endoplasmic reticulum (ER). How oligomerization of the PDI-like proteins control these activities is...
Protein disulfide isomerase–like proteins play opposing roles during retrotranslocation
Forster, Michele L., Sivick, Kelsey, Park, Young-nam, Arvan, Peter, Lencer, Wayne I., Tsai, Billy
Misfolded proteins in the endoplasmic reticulum (ER) are retained in the organelle or retrotranslocated to the cytosol for proteasomal degradation. ER chaperones that guide these opposing processes...
Rainey-Barger, Emily K., Magnuson, Brian, Tsai, Billy
The nonenveloped polyomavirus (Py) traffics from the plasma membrane to the endoplasmic reticulum (ER), where it penetrates the ER membrane, allowing the viral genome to reach the nucleus to cause...
Derlin-1 Facilitates the Retro-Translocation of Cholera Toxin
Bernardi, Kaleena M., Forster, Michele L., Lencer, Wayne I., Tsai, Billy
Cholera toxin (CT) intoxicates cells by using its receptor-binding B subunit (CTB) to traffic from the plasma membrane to the endoplasmic reticulum (ER). In this compartment, the catalytic A1 subunit...
The toxic effect of cholera toxin (CT) on target cells is caused by its A1 chain. This polypeptide is released from the holotoxin and unfolded in the lumen of the ER by the action of protein...
Qian, Mengding, Cai, Dawen, Verhey, Kristen J., Tsai, Billy
The mechanisms by which receptors guide intracellular virus transport are poorly characterized. The murine polyomavirus (Py) binds to the lipid receptor ganglioside GD1a and traffics to the...
Early Events during BK Virus Entry and Disassembly▿
Jiang, Mengxi, Abend, Johanna R., Tsai, Billy, Imperiale, Michael J.
BK virus (BKV) is a nonenveloped, ubiquitous human polyomavirus that establishes a persistent infection in healthy individuals. It can be reactivated, however, in immunosuppressed patients and cause...
The C-Terminal Domain of ERp29 Mediates Polyomavirus Binding, Unfolding, and Infection▿
Rainey-Barger, Emily K., Mkrtchian, Souren, Tsai, Billy
Penetration of the endoplasmic reticulum (ER) membrane by polyomavirus (PyV) is a decisive step in virus entry. We showed previously that the ER-resident factor ERp29 induces the local unfolding of...