Moore, Anne C., Kong, Wing-pui, Chakrabarti, Bimal K., Nabel, Gary J.
The effects of genetic adjuvants on humoral and cell-mediated immunity to two human immunodeficiency virus antigens, Env and Nef, have been examined in mice. Despite similar levels of gene expression...
Baig, Jamal, Levy, Daniel B., McKay, Paul F., Schmitz, Joern E., Santra, Sampa, Subbramanian, Ramu A., ...
Since most human immunodeficiency virus (HIV) infections are initiated following mucosal exposure to the virus, the anatomic containment or abortion of an HIV infection is likely to require...
Chakrabarti, Bimal K., Kong, Wing-pui, Wu, Bei-yue, Yang, Zhi-Yong, Friborg, Jacques, Ling, Xu, ...
In this study, we have investigated the effect of specific mutations in human immunodeficiency virus type 1 (HIV-1) envelope (Env) on antibody production in an effort to improve humoral immune...
Barouch, Dan H., McKay, Paul F., Sumida, Shawn M., Santra, Sampa, Jackson, Shawn S., Gorgone, Darci A., ...
Heterologous “prime-boost” regimens that involve priming with plasmid DNA vaccines and boosting with recombinant viral vectors have been shown to elicit potent virus-specific cytotoxic...
Lemiale, Franck, Kong, Wing-pui, Akyürek, Levent M., Ling, Xu, Huang, Yue, Chakrabarti, Bimal K., ...
Replication-defective adenovirus (ADV) vectors represent a promising potential platform for the development of a vaccine for AIDS. Although this vector is typically administered intramuscularly, it...
Immunogenicity of Multiple Gene and Clade Human Immunodeficiency Virus Type 1 DNA Vaccines
Kong, Wing-Pui, Huang, Yue, Yang, Zhi-Yong, Chakrabarti, Bimal K., Moodie, Zoe, Nabel, Gary J.
The ability to elicit an immune response to a spectrum of human immunodeficiency virus type 1 (HIV-1) gene products from divergent strains is a desirable feature of an AIDS vaccine. In this study, we...
Yang, Zhi-yong, Chakrabarti, Bimal K., Xu, Ling, Welcher, Brent, Kong, Wing-pui, Leung, Kwanyee, ...
Although the B clade of human immunodeficiency virus type 1 (HIV-1) envelopes (Env) includes five highly variable regions, each of these domains contains a subset of sequences that remain conserved....
Heterologous Envelope Immunogens Contribute to AIDS Vaccine Protection in Rhesus Monkeys
Letvin, Norman L., Huang, Yue, Chakrabarti, Bimal K., Xu, Ling, Seaman, Michael S., Beaudry, Kristin, ...
Because a strategy to elicit broadly neutralizing anti-human immunodeficiency virus type 1 (HIV-1) antibodies has not yet been found, the role of an Env immunogen in HIV-1 vaccine candidates remains...
Mascola, John R., Sambor, Anna, Beaudry, Kristin, Santra, Sampa, Welcher, Brent, Louder, Mark K., ...
Immunization with recombinant serotype 5 adenoviral (rAd5) vectors or a combination of DNA plasmid priming and rAd5 boosting is known to elicit potent immune responses. However, little data exist...
Seaman, Michael S., Xu, Ling, Beaudry, Kristin, Martin, Kristi L., Beddall, Margaret H., Miura, Ayako, ...
The development of a human immunodeficiency virus type 1 (HIV-1) vaccine that elicits potent cellular and humoral immune responses recognizing divergent strains of HIV-1 will be critical for...
Santra, Sampa, Seaman, Michael S., Xu, Ling, Barouch, Dan H., Lord, Carol I., Lifton, Michelle A., ...
The magnitude and durability of immune responses induced by replication-defective adenovirus serotype 5 (ADV5) vector-based vaccines were evaluated in the simian-human immunodeficiency virus/rhesus...
Yang, Zhi-yong, Chakrabarti, Bimal K., Xu, Ling, Welcher, Brent, Kong, Wing-pui, Leung, Kwanyee, ...
Moore, Anne C., Kong, Wing-pui, Chakrabarti, Bimal K., Nabel, Gary J.
The effects of genetic adjuvants on humoral and cell-mediated immunity to two human immunodeficiency virus antigens, Env and Nef, have been examined in mice. Despite similar levels of gene expression...
Baig, Jamal, Levy, Daniel B., McKay, Paul F., Schmitz, Joern E., Santra, Sampa, Subbramanian, Ramu A., ...
Since most human immunodeficiency virus (HIV) infections are initiated following mucosal exposure to the virus, the anatomic containment or abortion of an HIV infection is likely to require...
Chakrabarti, Bimal K., Kong, Wing-pui, Wu, Bei-yue, Yang, Zhi-Yong, Friborg, Jacques, Ling, Xu, ...
In this study, we have investigated the effect of specific mutations in human immunodeficiency virus type 1 (HIV-1) envelope (Env) on antibody production in an effort to improve humoral immune...
Barouch, Dan H., McKay, Paul F., Sumida, Shawn M., Santra, Sampa, Jackson, Shawn S., Gorgone, Darci A., ...
Heterologous “prime-boost” regimens that involve priming with plasmid DNA vaccines and boosting with recombinant viral vectors have been shown to elicit potent virus-specific cytotoxic...
Lemiale, Franck, Kong, Wing-pui, Akyürek, Levent M., Ling, Xu, Huang, Yue, Chakrabarti, Bimal K., ...
Replication-defective adenovirus (ADV) vectors represent a promising potential platform for the development of a vaccine for AIDS. Although this vector is typically administered intramuscularly, it...
Immunogenicity of Multiple Gene and Clade Human Immunodeficiency Virus Type 1 DNA Vaccines
Kong, Wing-Pui, Huang, Yue, Yang, Zhi-Yong, Chakrabarti, Bimal K., Moodie, Zoe, Nabel, Gary J.
The ability to elicit an immune response to a spectrum of human immunodeficiency virus type 1 (HIV-1) gene products from divergent strains is a desirable feature of an AIDS vaccine. In this study, we...
Yang, Zhi-yong, Chakrabarti, Bimal K., Xu, Ling, Welcher, Brent, Kong, Wing-pui, Leung, Kwanyee, ...
Although the B clade of human immunodeficiency virus type 1 (HIV-1) envelopes (Env) includes five highly variable regions, each of these domains contains a subset of sequences that remain conserved....
Heterologous Envelope Immunogens Contribute to AIDS Vaccine Protection in Rhesus Monkeys
Letvin, Norman L., Huang, Yue, Chakrabarti, Bimal K., Xu, Ling, Seaman, Michael S., Beaudry, Kristin, ...
Because a strategy to elicit broadly neutralizing anti-human immunodeficiency virus type 1 (HIV-1) antibodies has not yet been found, the role of an Env immunogen in HIV-1 vaccine candidates remains...
Mascola, John R., Sambor, Anna, Beaudry, Kristin, Santra, Sampa, Welcher, Brent, Louder, Mark K., ...
Immunization with recombinant serotype 5 adenoviral (rAd5) vectors or a combination of DNA plasmid priming and rAd5 boosting is known to elicit potent immune responses. However, little data exist...
Seaman, Michael S., Xu, Ling, Beaudry, Kristin, Martin, Kristi L., Beddall, Margaret H., Miura, Ayako, ...
The development of a human immunodeficiency virus type 1 (HIV-1) vaccine that elicits potent cellular and humoral immune responses recognizing divergent strains of HIV-1 will be critical for...
Santra, Sampa, Seaman, Michael S., Xu, Ling, Barouch, Dan H., Lord, Carol I., Lifton, Michelle A., ...
The magnitude and durability of immune responses induced by replication-defective adenovirus serotype 5 (ADV5) vector-based vaccines were evaluated in the simian-human immunodeficiency virus/rhesus...
Yang, Zhi-yong, Chakrabarti, Bimal K., Xu, Ling, Welcher, Brent, Kong, Wing-pui, Leung, Kwanyee, ...
A DNA Vaccine for Ebola Virus Is Safe and Immunogenic in a Phase I Clinical Trial▿ †
Martin, Julie E., Sullivan, Nancy J., Enama, Mary E., Gordon, Ingelise J., Roederer, Mario, Koup, Richard A., ...
Ebola viruses represent a class of filoviruses that causes severe hemorrhagic fever with high mortality. Recognized first in 1976 in the Democratic Republic of Congo, outbreaks continue to occur in...
Lysis of Human Immunodeficiency Virus Type 1 by a Specific Secreted Human Phospholipase A2▿
Kim, Jae-Ouk, Chakrabarti, Bimal K., Guha-Niyogi, Anuradha, Louder, Mark K., Mascola, John R., Ganesh, Lakshmanan, ...
Phospholipase A2 (PLA2) proteins affect cellular activation, signal transduction, and possibly innate immunity. A specific secretory PLA2, sPLA2-X, is shown here to neutralize human immunodeficiency...
Dey, Barna, Svehla, Krisha, Xu, Ling, Wycuff, Dianne, Zhou, Tongqing, Voss, Gerald, ...
The human immunodeficiency virus type 1 (HIV-1) exterior envelope glycoprotein, gp120, possesses conserved binding sites for interaction with the primary virus receptor, CD4, and also for the...