Birgit Görtz

Tumour necrosis factor activates the mitogen-activated protein kinases p38α and ERK in the synovial membrane in vivo (2005)

Görtz, Birgit, Hayer, Silvia, Tuerck, Birgit, Zwerina, Jochen, Smolen, Josef S, Schett, Georg

Abstract Tumour necrosis factor (TNF) is considered to be a major factor in chronic synovial inflammation and is an inducer of mitogen-activated protein kinase (MAPK) signalling. In the present study...

Tumour necrosis factor activates the mitogen-activated protein kinases p38α and ERK in the synovial membrane in vivo

Görtz, Birgit, Hayer, Silvia, Tuerck, Birgit, Zwerina, Jochen, Smolen, Josef S, Schett, Georg

Tumour necrosis factor (TNF) is considered to be a major factor in chronic synovial inflammation and is an inducer of mitogen-activated protein kinase (MAPK) signalling. In the present study we...

Tumour necrosis factor activates the mitogen-activated protein kinases p38α and ERK in the synovial membrane in vivo

Görtz, Birgit, Hayer, Silvia, Tuerck, Birgit, Zwerina, Jochen, Smolen, Josef S, Schett, Georg

Tumour necrosis factor (TNF) is considered to be a major factor in chronic synovial inflammation and is an inducer of mitogen-activated protein kinase (MAPK) signalling. In the present study we...

Repair of Local Bone Erosions and Reversal of Systemic Bone Loss Upon Therapy with Anti-Tumor Necrosis Factor in Combination with Osteoprotegerin or Parathyroid Hormone in Tumor Necrosis Factor-Mediated Arthritis

Redlich, Kurt, Görtz, Birgit, Hayer, Silvia, Zwerina, Jochen, Doerr, Nicholas, Kostenuik, Paul, ...

Local bone erosion and systemic bone loss are hallmarks of rheumatoid arthritis and cause progressive disability. Tumor necrosis factor (TNF) is a key mediator of arthritis and acts catabolically on...

Mutations and Allelic Deletions of the MEN1 Gene Are Associated with a Subset of Sporadic Endocrine Pancreatic and Neuroendocrine Tumors and Not Restricted to Foregut Neoplasms

Görtz, Birgit, Roth, Jürgen, Krähenmann, Akiko, De Krijger, Ronald R., Muletta-Feurer, Seraina, Rütimann, Katrin, ...

Endocrine pancreatic tumors (EPT) and neuroendocrine tumors (NET) occur sporadically and rarely in association with multiple endocrine neoplasia type 1 (MEN1). We analyzed the frequency of allelic...

CD44 is a determinant of inflammatory bone loss

Hayer, Silvia, Steiner, Günter, Görtz, Birgit, Reiter, Erika, Tohidast-Akrad, Makiyeh, Amling, Michael, ...

Chronic inflammation is a major trigger of local and systemic bone loss. Disintegration of cell–matrix interaction is a prerequisite for the invasion of inflammatory tissue into bone. CD44 is a...