Pestka, Jan, Zeisel, Mirjam, Bläser, Edith, Schürmann, Peter, Bartosch, Birke, Cosset, François-Loïc, ...
In contrast to a detailed understanding of antiviral cellular immune responses, the impact of neutralizing antibodies for the resolution of acute hepatitis C is poorly defined. The analysis of...
Pestka, Jan, Zeisel, Mirjam, Bläser, Edith, Schürmann, Peter, Bartosch, Birke, Cosset, François-Loïc, ...
In contrast to a detailed understanding of antiviral cellular immune responses, the impact of neutralizing antibodies for the resolution of acute hepatitis C is poorly defined. The analysis of...
Pestka, Jan, Zeisel, Mirjam, Bläser, Edith, Schürmann, Peter, Bartosch, Birke, Cosset, François-Loïc, ...
In contrast to a detailed understanding of antiviral cellular immune responses, the impact of neutralizing antibodies for the resolution of acute hepatitis C is poorly defined. The analysis of...
Bartosch, Birke, Dubuisson, Jean, Cosset, François-Loïc
The study of hepatitis C virus (HCV), a major cause of chronic liver disease, has been hampered by the lack of a cell culture system supporting its replication. Here, we have successfully generated...
Bartosch, Birke, Dubuisson, Jean, Cosset, François-Loïc
The study of hepatitis C virus (HCV), a major cause of chronic liver disease, has been hampered by the lack of a cell culture system supporting its replication. Here, we have successfully generated...
Bartosch, Birke, Dubuisson, Jean, Cosset, François-Loïc
The study of hepatitis C virus (HCV), a major cause of chronic liver disease, has been hampered by the lack of a cell culture system supporting its replication. Here, we have successfully generated...
The stability and turnover of Xenopus cyclin E. (1999)
Thesis (Ph. D.)--University of London, 1999.
Bartosch, Birke, Bukh, Jens, Meunier, Jean-Christophe, Granier, Christelle, Engle, Ronald E., Blackwelder, William C., ...
Our understanding of the humoral immune response to hepatitis C virus (HCV) is limited because the virus can be studied only in humans and chimpanzees and because previously described neutralization...
Characterization of Functional Hepatitis C Virus Envelope Glycoproteins
Op De Beeck, Anne, Voisset, Cécile, Bartosch, Birke, Ciczora, Yann, Cocquerel, Laurence, Keck, Zhenyong, ...
Hepatitis C virus (HCV) encodes two envelope glycoproteins, E1 and E2, that assemble as a noncovalent heterodimer which is mainly retained in the endoplasmic reticulum. Because assembly into...
Yu, Mei-ying W., Bartosch, Birke, Zhang, Pei, Guo, Zheng-ping, Renzi, Paula M., Shen, Li-ming, ...
The role of humoral immunity in hepatitis C virus (HCV) infections is uncertain. Nevertheless, there is increasing evidence for neutralizing antibodies to HCV in the serum or plasma of chronically...
Evidence and Consequence of Porcine Endogenous Retrovirus Recombination
Bartosch, Birke, Stefanidis, Dimitrios, Myers, Richard, Weiss, Robin, Patience, Clive, Takeuchi, Yasuhiro
The genetic nature and biological effects of recombination between porcine endogenous retroviruses (PERV) were studied. An infectious molecular clone was generated from a high-titer, human-tropic...
Determinants of High Titer in Recombinant Porcine Endogenous Retroviruses
Harrison, Ian, Takeuchi, Yasuhiro, Bartosch, Birke, Stoye, Jonathan P.
Porcine endogenous retroviruses (PERVs) pose a potential stumbling block for therapeutic xenotransplantation, with the greatest threat coming from viruses generated by recombination between members...
Meunier, Jean-Christophe, Engle, Ronald E., Faulk, Kristina, Zhao, Ming, Bartosch, Birke, Alter, Harvey, ...
The lack of a cell culture system to support hepatitis C virus (HCV) replication has hampered studies of this frequent cause of chronic liver disease. However, pseudotyped retroviral particles (pp)...
Lavillette, Dimitri, Morice, Yoann, Germanidis, Georgios, Donot, Peggy, Soulier, Alexandre, Pagkalos, Emanuil, ...
The factors leading to spontaneous clearance of hepatitis C virus (HCV) or to viral persistence are elusive. Understanding virus-host interactions that enable acute HCV clearance is key to the...
Bartosch, Birke, Verney, Géraldine, Dreux, Marlène, Donot, Peggy, Morice, Yoann, Penin, François, ...
Hepatitis C virus (HCV) circulates in the bloodstream in different forms, including complexes with immunoglobulins and/or lipoproteins. To address the significance of such associations, we produced...
Role of N-Linked Glycans in the Functions of Hepatitis C Virus Envelope Glycoproteins
Goffard, Anne, Callens, Nathalie, Bartosch, Birke, Wychowski, Czeslaw, Cosset, François-Loïc, Montpellier, Claire, ...
Hepatitis C virus (HCV) encodes two viral envelope glycoproteins. E1 contains 4 or 5 N-linked glycosylation sites and E2 contains up to 11, with most of the sites being well conserved, suggesting...
Owsianka, Ania, Tarr, Alexander W., Juttla, Vicky S., Lavillette, Dimitri, Bartosch, Birke, Cosset, François-Loïc, ...
Hepatitis C virus (HCV) remains a significant threat to the general health of the world's population, and there is a pressing need for the development of new treatments and preventative vaccines....
Analysis of a Highly Flexible Conformational Immunogenic Domain A in Hepatitis C Virus E2
Keck, Zhen-Yong, Li, Ta-Kai, Xia, Jinming, Bartosch, Birke, Cosset, François-Loïc, Dubuisson, Jean, ...
Hepatitis C (HCV) E2 glycoprotein is involved in virus attachment and entry, and its structural organization is largely unknown. Characterization of a panel of human monoclonal antibodies (HMAbs) to...
Callens, Nathalie, Ciczora, Yann, Bartosch, Birke, Vu-Dac, Ngoc, Cosset, François-Loïc, Pawlotsky, Jean-Michel, ...
The N terminus of hepatitis C virus (HCV) envelope glycoprotein E2 contains a hypervariable region (HVR1) which has been proposed to play a role in viral entry. Despite strong amino acid variability,...
Bartosch, Birke, Bukh, Jens, Meunier, Jean-Christophe, Granier, Christelle, Engle, Ronald E., Blackwelder, William C., ...
Our understanding of the humoral immune response to hepatitis C virus (HCV) is limited because the virus can be studied only in humans and chimpanzees and because previously described neutralization...
Characterization of Functional Hepatitis C Virus Envelope Glycoproteins
Op De Beeck, Anne, Voisset, Cécile, Bartosch, Birke, Ciczora, Yann, Cocquerel, Laurence, Keck, Zhenyong, ...
Hepatitis C virus (HCV) encodes two envelope glycoproteins, E1 and E2, that assemble as a noncovalent heterodimer which is mainly retained in the endoplasmic reticulum. Because assembly into...
Yu, Mei-ying W., Bartosch, Birke, Zhang, Pei, Guo, Zheng-ping, Renzi, Paula M., Shen, Li-ming, ...
The role of humoral immunity in hepatitis C virus (HCV) infections is uncertain. Nevertheless, there is increasing evidence for neutralizing antibodies to HCV in the serum or plasma of chronically...
Evidence and Consequence of Porcine Endogenous Retrovirus Recombination
Bartosch, Birke, Stefanidis, Dimitrios, Myers, Richard, Weiss, Robin, Patience, Clive, Takeuchi, Yasuhiro
The genetic nature and biological effects of recombination between porcine endogenous retroviruses (PERV) were studied. An infectious molecular clone was generated from a high-titer, human-tropic...
Determinants of High Titer in Recombinant Porcine Endogenous Retroviruses
Harrison, Ian, Takeuchi, Yasuhiro, Bartosch, Birke, Stoye, Jonathan P.
Porcine endogenous retroviruses (PERVs) pose a potential stumbling block for therapeutic xenotransplantation, with the greatest threat coming from viruses generated by recombination between members...
Meunier, Jean-Christophe, Engle, Ronald E., Faulk, Kristina, Zhao, Ming, Bartosch, Birke, Alter, Harvey, ...
The lack of a cell culture system to support hepatitis C virus (HCV) replication has hampered studies of this frequent cause of chronic liver disease. However, pseudotyped retroviral particles (pp)...
Lavillette, Dimitri, Morice, Yoann, Germanidis, Georgios, Donot, Peggy, Soulier, Alexandre, Pagkalos, Emanuil, ...
The factors leading to spontaneous clearance of hepatitis C virus (HCV) or to viral persistence are elusive. Understanding virus-host interactions that enable acute HCV clearance is key to the...
Bartosch, Birke, Verney, Géraldine, Dreux, Marlène, Donot, Peggy, Morice, Yoann, Penin, François, ...
Hepatitis C virus (HCV) circulates in the bloodstream in different forms, including complexes with immunoglobulins and/or lipoproteins. To address the significance of such associations, we produced...
Role of N-Linked Glycans in the Functions of Hepatitis C Virus Envelope Glycoproteins
Goffard, Anne, Callens, Nathalie, Bartosch, Birke, Wychowski, Czeslaw, Cosset, François-Loïc, Montpellier, Claire, ...
Hepatitis C virus (HCV) encodes two viral envelope glycoproteins. E1 contains 4 or 5 N-linked glycosylation sites and E2 contains up to 11, with most of the sites being well conserved, suggesting...
Owsianka, Ania, Tarr, Alexander W., Juttla, Vicky S., Lavillette, Dimitri, Bartosch, Birke, Cosset, François-Loïc, ...
Hepatitis C virus (HCV) remains a significant threat to the general health of the world's population, and there is a pressing need for the development of new treatments and preventative vaccines....
Analysis of a Highly Flexible Conformational Immunogenic Domain A in Hepatitis C Virus E2
Keck, Zhen-Yong, Li, Ta-Kai, Xia, Jinming, Bartosch, Birke, Cosset, François-Loïc, Dubuisson, Jean, ...
Hepatitis C (HCV) E2 glycoprotein is involved in virus attachment and entry, and its structural organization is largely unknown. Characterization of a panel of human monoclonal antibodies (HMAbs) to...
Callens, Nathalie, Ciczora, Yann, Bartosch, Birke, Vu-Dac, Ngoc, Cosset, François-Loïc, Pawlotsky, Jean-Michel, ...
The N terminus of hepatitis C virus (HCV) envelope glycoprotein E2 contains a hypervariable region (HVR1) which has been proposed to play a role in viral entry. Despite strong amino acid variability,...
Pestka, Jan M., Zeisel, Mirjam B., Bläser, Edith, Schürmann, Peter, Bartosch, Birke, Cosset, Francois-Loïc, ...
In contrast to a detailed understanding of antiviral cellular immune responses, the impact of neutralizing antibodies for the resolution of acute hepatitis C is poorly defined. The analysis of...
Infectious Hepatitis C Virus Pseudo-particles Containing Functional E1–E2 Envelope Protein Complexes
Bartosch, Birke, Dubuisson, Jean, Cosset, François-Loïc
The study of hepatitis C virus (HCV), a major cause of chronic liver disease, has been hampered by the lack of a cell culture system supporting its replication. Here, we have successfully generated...
Dreux, Marlène, Dao Thi, Viet Loan, Fresquet, Judith, Guérin, Maryse, Julia, Zélie, Verney, Géraldine, ...
HCV entry into cells is a multi-step and slow process. It is believed that the initial capture of HCV particles by glycosaminoglycans and/or lipoprotein receptors is followed by coordinated...
Characterization of Lassa Virus Cell Entry and Neutralization with Lassa Virus Pseudoparticles▿
Cosset, François-Loic, Marianneau, Philippe, Verney, Geraldine, Gallais, Fabrice, Tordo, Noel, Pécheur, Eve-Isabelle, ...
The cell entry and humoral immune response of the human pathogen Lassa virus (LV), a biosafety level 4 (BSL4) Old World arenavirus, are not well characterized. LV pseudoparticles (LVpp) are a...