IL-1 breaks tolerance through inhibition of regulatory T cell function (2005)
OSullivan, BJ, Thomas, HE, Pai, S, Steptoe, RJ, Kay, TW, Thomas, R
The mechanism of inflammation in RelB deficient mice (2005)
Pai, S, OSullivan, BJ, MacDonald, KP, Duggan, E, Gerondakis, S, Hill, G, ...
Thomas, R, Pettit, AR, MacDonald, KPA, OSullivan, BJ
Mice with targeted RelB mutations demonstrated an essential role for RelB in immune responses and in myeloid dendritic cell differentiation. Human studies suggested a more global transcriptional role...
OSullivan, BJ, MacDonald, KPA, Pettit, AR, Thomas, R
Mice with targeted RelB mutations demonstrated an essential role for RelB in immune responses and in myeloid dendritic cell differentiation. Human studies suggested a more global transcriptional role...
OSullivan, BJ, MacDonald, KPA, Pettit, AR, Thomas, R
Mice with targeted RelB mutations demonstrated an essential role for RelB in immune responses and in myeloid dendritic cell differentiation. Human studies suggested a more global transcriptional role...
Pai, S, OSullivan, BJ, Cooper, L, Thomas, R, Khanna, R
Previous studies have shown that Epstein-Barr virus-encoded latent membrane protein 1 (LMP1) is uniquely able to up-regulate the expression of the peptide transporters (referred to as TAP-1 and...
An understanding of the biochemical control of dendritic cell (DC) differentiation/activation is essential for improving T cell immunity by various immunotherapeutic approaches, including DC...
T cells signaled by NF-kappa B- dendritic cells are sensitized not anergic to subsequent activation
Thompson, AG, OSullivan, BJ, Beamish, H, Thomas, R
Paradoxically, while peripheral self-tolerance exists for constitutively presented somatic self Ag, self-peptide recognized in the context of MHC class II has been shown to sensitize T cells for...
IL-1 breaks tolerance through inhibition of regulatory T cell function
OSullivan, BJ, Thomas, HE, Pai, S, Steptoe, RJ, Kay, TW, Thomas, R
The mechanism of inflammation in RelB deficient mice
Pai, S, OSullivan, BJ, MacDonald, KP, Duggan, E, Gerondakis, S, Hill, G, ...
IL-1 beta breaks tolerance through expansion of CD25(+) effector T cells
OSullivan, BJ, Thomas, HE, Pai, S, Santamaria, P, Iwakura, Y, Steptoe, RJ, ...
IL-1 is a key proinflammatory driver of several autoimmune diseases including juvenile inflammatory arthritis, diseases with mutations in the NALP/cryopyrin complex and Crohn's disease, and is...