Microforce measurement system and experimental study of microforces in controlled environment (2009)
Chang, Bo, Mandal, Md Nawajes A., Chavali, Venkata R.M., Hawes, Norman L., Khan, Naheed W., Hurd, Ronald E., ...
We observed that a naturally occurring mouse strain developed age-related retinal degeneration (arrd2). These mice had normal fundi, electroretinograms (ERGs) and retinal histology at 6 months of...
A model for familial exudative vitreoretinopathy caused by LPR5 mutations (2008)
Xia, Chun-Hong, Liu, Haiquan, Cheung, Debra, Wang, Meng, Cheng, Catherine, Du, Xin, ...
We have identified a mouse recessive mutation that leads to attenuated and hyperpermeable retinal vessels, recapitulating some pathological features of familial exudative vitreoretinopathy (FEVR) in...
Chang, Bo, Khanna, Hemant, Hawes, Norman, Jimeno, David, He, Shirley, Lillo, Concepcion, ...
Centrosome- and cilia-associated proteins play crucial roles in establishing polarity and regulating intracellular transport in post-mitotic cells. Using genetic mapping and positional candidate...
Zheng, Qing Yin, Yan, Denise, Ouyang, Xiao Mei, Du, Li Lin, Yu, Heping, Chang, Bo, ...
Mutations in genes coding for cadherin 23 and protocadherin 15 cause deafness in both mice and humans. Here, we provide evidence that mutations at these two cadherin loci can interact to cause...
Zheng, Qing Yin, Yan, Denise, Ouyang, Xiao Mei, Du, Li Lin, Yu, Heping, Chang, Bo, ...
Mutations in the genes coding for cadherin 23 and protocadherin 15 cause deafness in both mice and humans. Here we provide evidence that mutations at these two cadherin loci can interact to cause...
Zheng, Qing Yin, Yan, Denise, Ouyang, Xiao Mei, Du, Li Lin, Yu, Heping, Chang, Bo, ...
Mutations in the genes coding for cadherin 23 and protocadherin 15 cause deafness in both mice and humans. Here we provide evidence that mutations at these two cadherin loci can interact to cause...
Mehalow, Adrienne K., Kameya, Shuhei, Smith, Richard S., Hawes, Norman L., Denegre, James M., Young, James A., ...
Mutations within the CRB1 gene have been shown to cause human retinal diseases including retinitis pigmentosa (RP) and Leber congenital amaurosis (LCA). We have recently identified a mouse model,...
Johnson, Kenneth R., Gagnon, Leona H., Webb, Lisa S., Peters, Luanne L., Hawes, Norman L., Chang, Bo, ...
We mapped two new recessive mutations causing circling behavior and deafness to the same region on Chromosome 7 and showed they are allelic by complementation analysis. One was named "deaf circler"...
Johnson, Kenneth R., Gagnon, Leona H., Webb, Lisa S., Peters, Luanne L., Hawes, Norman L., Chang, Bo, ...
We mapped two new recessive mutations causing circling behavior and deafness to the same region on chromosome 7 and showed they are allelic by complementation analysis. One was named ‘deaf...
Mehalow, Adrienne K., Kameya, Shuhei, Smith, Richard S., Hawes, Norman L., Denegre, James M., Young, James A., ...
Mutations within the CRB1 gene have been shown to cause human retinal diseases including retinitis pigmentosa and Leber congenital amaurosis. We have recently identified a mouse model, retinal...
Mehalow, Adrienne K., Kameya, Shuhei, Smith, Richard S., Hawes, Norman L., Denegre, James M., Young, James A., ...
Mutations within the CRB1 gene have been shown to cause human retinal diseases including retinitis pigmentosa (RP) and Leber congenital amaurosis (LCA). We have recently identified a mouse model,...
Johnson, Kenneth R., Gagnon, Leona H., Webb, Lisa S., Peters, Luanne L., Hawes, Norman L., Chang, Bo, ...
We mapped two new recessive mutations causing circling behavior and deafness to the same region on Chromosome 7 and showed they are allelic by complementation analysis. One was named "deaf circler"...
Chang, Bo, Wang, Xin, Hawes, Norman L., Ojakian, Ryan, Davisson, Muriel T., Lo, Woo-Kuen, ...
Mutations of connexin α8 (GJA8 or Cx50) and connexin α3 (GJA3 or Cx46) in humans have been reported to cause cataracts with semi-dominant inheritance patterns. Targeted null mutations in Gja8 and...
Kameya, Shuhei, Hawes, Norman L., Chang, Bo, Heckenlively, John R., Naggert, Jürgen K., Nishina, Patsy M.
The autosomal recessive mouse mutation retinal degeneration 6 (rd6) causes small, white retinal spots and progressive photoreceptor degeneration similar to that observed in human flecked retinal...
Chang, Bo, Smith, Richard S, Peters, Maureen, Savinova, Olga V, Hawes, Norman L, Zabaleta, Adriana, ...
Abstract Background Glaucoma is a blinding disease usually associated with high intraocular pressure (IOP). In some families, abnormal anterior segment development contributes to glaucoma. The genes...
Genetic modification of glaucoma associated phenotypes between AKXD-28/Ty and DBA/2J mice (2001)
Anderson, Michael G, Smith, Richard S, Savinova, Olga V, Hawes, Norman L, Chang, Bo, Zabaleta, Adriana, ...
Abstract Background Glaucoma is a common disease but its molecular etiology is poorly understood. It involves retinal ganglion cell death and optic nerve damage that is often associated with elevated...
The Bst locus on mouse chromosome 16 is associated with age-related subretinal neovascularization
Smith, Richard S., John, Simon W. M., Zabeleta, Adriana, Davisson, Muriel T., Hawes, Norman L., Chang, Bo
Ocular neovascularization is the leading cause of blindness in developed countries and often causes rapid loss of vision in age-related macular degeneration. Acute visual loss is most often due to...
Akhmedov, Novrouz B., Piriev, Natik I., Chang, Bo, Rapoport, Ana Lia, Hawes, Norman L., Nishina, Patsy M., ...
The rd7 mouse, an animal model for hereditary retinal degeneration, has some characteristics similar to human flecked retinal disorders. Here we report the identification of a deletion in a...
Genetic modification of glaucoma associated phenotypes between AKXD-28/Ty and DBA/2J mice
Anderson, Michael G, Smith, Richard S, Savinova, Olga V, Hawes, Norman L, Chang, Bo, Zabaleta, Adriana, ...
Chang, Bo, Smith, Richard S, Peters, Maureen, Savinova, Olga V, Hawes, Norman L, Zabaleta, Adriana, ...
The Bst locus on mouse chromosome 16 is associated with age-related subretinal neovascularization
Smith, Richard S., John, Simon W. M., Zabeleta, Adriana, Davisson, Muriel T., Hawes, Norman L., Chang, Bo
Ocular neovascularization is the leading cause of blindness in developed countries and often causes rapid loss of vision in age-related macular degeneration. Acute visual loss is most often due to...
Akhmedov, Novrouz B., Piriev, Natik I., Chang, Bo, Rapoport, Ana Lia, Hawes, Norman L., Nishina, Patsy M., ...
The rd7 mouse, an animal model for hereditary retinal degeneration, has some characteristics similar to human flecked retinal disorders. Here we report the identification of a deletion in a...
Genetic modification of glaucoma associated phenotypes between AKXD-28/Ty and DBA/2J mice
Anderson, Michael G, Smith, Richard S, Savinova, Olga V, Hawes, Norman L, Chang, Bo, Zabaleta, Adriana, ...
Chang, Bo, Smith, Richard S, Peters, Maureen, Savinova, Olga V, Hawes, Norman L, Zabaleta, Adriana, ...
Cideciyan, Artur V., Aleman, Tomas S., Jacobson, Samuel G., Khanna, Hemant, Sumaroka, Alexander, Aguirre, Geoffrey K., ...
Mutations in the centrosomal-ciliary gene CEP290/NPHP6 are associated with Joubert syndrome and are the most common cause of the childhood recessive blindness known as Leber congenital amaurosis...
Maddox, Dennis M, Vessey, Kirstan A, Yarbrough, Gary L, Invergo, Brandon M, Cantrell, Donald R, Inayat, Samsoon, ...
An electroretinogram (ERG) screen identified a mouse with a normal a-wave but lacking a b-wave, and as such it was designated no b-wave3 (nob3). The nob3 phenotype mapped to chromosome 11 in a region...
Functional interchangeability of rod and cone transducin α-subunits
Deng, Wen-Tao, Sakurai, Keisuke, Liu, Jianwen, Dinculescu, Astra, Li, Jie, Pang, Jijing, ...
Rod and cone photoreceptors use similar but distinct sets of phototransduction proteins to achieve different functional properties, suitable for their role as dim and bright light receptors,...