Bo Huang

Bose-Einstein Condensation of Strontium (2009)

Stellmer, Simon, Tey, Meng Khoon, Huang, Bo, Grimm, Rudolf, Schreck, Florian

We report on the attainment of Bose-Einstein condensation (BEC) with ultracold strontium atoms. We use the 84Sr isotope, which has a low natural abundance but offers excellent scattering properties...

A Fast Level Set Method for Synthetic Aperture Radar Ocean Image Segmentation (2009)

Xiaoxia Huang, Bo Huang, Hongga Li

Segmentation of high noise imagery like Synthetic Aperture Radar (SAR) images is still one of the most challenging tasks in image processing. While level set, a novel approach based on the analysis...

A Fast Level Set Method for Synthetic Aperture Radar Ocean Image Segmentation (2009)

Xiaoxia Huang, Bo Huang, Hongga Li

Segmentation of high noise imagery like Synthetic Aperture Radar (SAR) images is still one of the most challenging tasks in image processing. While level set, a novel approach based on the analysis...

Huang and Fery 1 Aiding Route Decision for Hazardous Material Transportation (2008)

Bo Huang, Pierre Fery

Abstract. This research attempts to build a framework for determination of optimal routes for hazardous material transportation. Previous works have suggested incorporation of many conflicting...

SYNTHESIS OF THE FULLY PROTECTED PHOSPHORAMIDITE OF THE BENZENE-DNA ADDUCT, N2- (4-HYDROXYPHENYL)-2'-DEOXYGUANOSINE AND INCORPORATION OF THE LATER INTO DNA OLIGOMERS (2008)

Huang, Bo

N2-(4-Hydroxyphenyl)-2'-deoxyguanosine-5'-O-DMT-3'-phosphoramidite has been synthesized and used to incorporate the N2-(4-hydroxyphenyl)-2'-dG (N2-4-HOPh-dG) into DNA, using solid-state synthesis...

Model and Query Language (2008)

Bo Huang, Christophe Claramunt

Spatio-temporal databases are a topic of growing research interest but there is still little work reported on spatio-temporal query languages in line with the Object Database Management Group (ODMG)...

An Object Model with Parametric Polymorphism for Dynamic Segmentation (2008)

Bo Huang

Dynamic segmentation is commonly viewed as one of the most effective aspects of GIS for transportation applications. To date, much of this effort has focused on relational data models, with object...

Research Article GIS and genetic algorithms for HAZMAT route planning with security considerations (2008)

Bo Huang, Ruey Long Cheu

Abstract. Singapore is the third largest oil-refining centre in the world, with a large petrochemical hub located at Jurong Island. In view of the increasing concern for transportation security,...

Boosting the Performance of Multimedia Applications Using SIMD Instructions* (2008)

Weihua Jiang, Chao Mei, Bo Huang, Jianhui Li, Jiahua Zhu, Binyu Zang, ...

Abstract. Modern processors ’ multimedia extensions (MME) provide SIMD ISAs to boost the performance of typical operations in multimedia applications. However, automatic vectorization support for...

A genome-wide screen identifies genes required for formation of the wobble nucleoside 5-methoxycarbonylmethyl-2-thiouridine in Saccharomyces cerevisiae (2008)

Huang, Bo, Lu, Jian, Byström, Anders S.

We recently showed that the γ-subunit of Kluyveromyces lactis killer toxin (γ-toxin) is a tRNA endonuclease that cleaves , , and 3′ of the wobble nucleoside...

Kluyveromyces lactis {gamma}-toxin, a ribonuclease that recognizes the anticodon stem loop of tRNA (2008)

Lu, Jian, Esberg, Anders, Huang, Bo, Byström, Anders S.

Kluyveromyces lactis γ-toxin is a tRNA endonuclease that cleaves Saccharomyces cerevisiae $${\mathrm{tRNA}}_{{\mathrm{mcm}}^{5}{s}^{2}\mathrm{UUC}}^{\mathrm{Glu}3}$$,...

Model and Query Language (2007)

Bo Huang, Christophe Claramunt

Spatio-temporal databases are a topic of growing research interest but there is still little work reported on spatio-temporal query languages in line with the Object Database Management Group (ODMG)...

Research Article An integration of GIS, virtual reality and the Internet for visualization, analysis and exploration of spatial data (2007)

Bo Huang, Bin Jiang, Hui Li

Abstract. This paper explores the way in which GIS, Virtual Reality (VR) and the Internet are closely integrated through the link of Virtual Reality Modelling Language (VRML) for spatial data...

A Spatio-Temporal Object Model and Query Language (2007)

Bo Huang, Michael F. Worboys, Chris Johnson, John Stell, Keith Mason

Snodgrass, 1995) have mostly been studied on parallel, but clearly separate tracks. As geophenomena are associated with both space and time, there has been a growing interest in the integration of...

Formation and function of wobble uridine modifications in transfer RNA of Saccharomyces cerevisiae (2007)

Huang, Bo

Transfer RNAs (tRNAs) act as adaptor molecules in decoding messenger RNA into protein. Frequently found in tRNAs are different modified nucleosides, which are derivatives of the four normal...

Formation and function of wobble uridine modifications in transfer RNA of Saccharomyces cerevisiae (2007)

Huang, Bo

Transfer RNAs (tRNAs) act as adaptor molecules in decoding messenger RNA into protein. Frequently found in tRNAs are different modified nucleosides, which are derivatives of the four normal...

A conserved modified wobble nucleoside (mcm5s2U) in lysyl-tRNA is required for viability in yeast (2007)

Björk, Glenn R., Huang, Bo, Persson, Olof P., Byström, Anders S.

Transfer RNAs specific for Gln, Lys, and Glu from all organisms (except Mycoplasma) and organelles have a 2-thiouridine derivative (xm5s2U) as wobble nucleoside. These tRNAs read the A- and G-ending...

Nitric oxide controls nuclear export of APE1/Ref-1 through S-nitrosation of Cysteines 93 and 310 (2007)

Qu, Jing, Liu, Guang-Hui, Huang, Bo, Chen, Chang

Apurinic/apyrimidinic endonuclease 1/redox effector factor-1 (APE1/Ref-1, abbreviated as APE1) is a molecule with dual functions in DNA repair and redox regulation of transcription factors....

Funneled Landscape Leads to Robustness of Cell Networks: Yeast Cell Cycle (2006)

Jin Wang, Bo Huang, Xuefeng Xia, Zhirong Sun

We uncovered the underlying energy landscape for a cellular network. We discovered that the energy landscape of the yeast cell-cycle network is funneled towards the global minimum (G0/G1 phase) from...

Funneled Landscape Leads to Robustness of Cell Networks: Yeast Cell Cycle (2006)

Jin Wang, Bo Huang, Xuefeng Xia, Zhirong Sun

Cellular networks have often been formulated with a set of chemical rate equations. These dynamical descriptions are inherently local. To probe the global properties such as function and robustness...

int Data; (2006)

Xing Huang, Bo Huang

Abstract: Bytes-split index Sort: bytes-split index sort (BSIS), is an non-compare-based sorting algorithm. The algorithm splits every digit of a sequence into m (m> = 2) bytes and constructs m...

Plasma Metallothionein Antibody and Cadmium-Induced Renal Dysfunction in an Occupational Population in China (2006)

Chen, Liang, Jin, Taiyi, Huang, Bo, Chang, Xiuli, Lei, Lijian, Nordberg, Gunnar F., ...

It has been reported that anti-metallothionein (a metallothionein antibody) is present in the circulation of healthy subjects and in patients suffering from atopic dermatitis. The aim of this study...

Two ellipse-based pruning methods for group nearest neighbor queries (2005)

Hongga Li, Bo Huang

Group nearest neighbor (GNN) queries are a relatively new type of operations in spatial database applications. Different from a traditional kNN query which specifies a single query point only, a GNN...

Declaration (2005)

Bo Huang, Dr. Nicole Bordes, Prof Bernard Pailthorpe, Bo Huang

The work presented in this thesis is original and has not been previously submitted under any circumstances in whole or in part. Concepts and material established by previous authors and presented as...

An early step in wobble uridine tRNA modification requires the Elongator complex (2005)

HUANG, BO, JOHANSSON, MARCUS J.O., BYSTRÖM, ANDERS S.

Elongator has been reported to be a histone acetyltransferase complex involved in elongation of RNA polymerase II transcription. In Saccharomyces cerevisiae, mutations in any of the six Elongator...

The Kluyveromyces lactis {gamma}-toxin targets tRNA anticodons (2005)

LU, JIAN, HUANG, BO, ESBERG, ANDERS, JOHANSSON, MARCUS J.O., BYSTRÖM, ANDERS S.

Kluyveromyces lactis killer strains secrete a heterotrimeric toxin (zymocin), which causes an irreversible growth arrest of sensitive yeast cells. Despite many efforts, the target(s) of the cytotoxic...

Plasma Metallothionein Antibody and Cadmium-Induced Renal Dysfunction in an Occupational Population in China (2005)

Chen, Liang, Jin, Taiyi, Huang, Bo, Chang, Xiuli, Lei, Lijiang, Nordberg, Gunnar F., ...

It has been reported that anti-metallothionein (a metallothionein antibody) is present in the circulation of healthy subjects and in patients suffering from atopic dermatitis. The aim of this study...

Geovisualization for planning support systems (2003)

Bin Jiang, Bo Huang, Vit Vasek

Abstract: Planning support systems can be defined as spatial decision support systems, and they consist of three important components, namely: data, models, and geovisualisation (Klosterman 1999). In...

Web-based Dynamic and Interactive Environmental Visualization (2003)

Bo Huang

The development of novel interactive visualizations can substantially contribute to environmental modeling and understanding of complex environmental processes. To allow the Web Map Service (WMS) to...

Fluorescence Emission and Absorption Spectra of Single Anabaena sp. Strain PCC7120 Cells¶ (2002)

Lizhen Ying, Xu Huang, Bo Huang, Jia Xie, Jindong Zhao, Xin Sheng Zhao

The fluorescence emission and absorption spectra of single Anabaena sp. strain PCC7120 cells including vegetative cells and heterocysts have been studied in intact filaments in vivo with confocal...

AVTOP: a full integration of TOPMODEL into GIS (2002)

Bo Huang, Bin Jiang, Developer B. Huang, B. Jiang

The integration of environmental models and Geographical Information Systems (GIS) usually takes two approaches: loose coupling and tight coupling. This paper, however, presents a full coupling...

2001) Geovisualisation for planning support systems (2001)

Bin Jiang, Bo Huang, Vit Vasek

Planning support systems can be defined as spatial decision support systems, and they consists of three important components, i.e. data, models and geovisualisation (Klosterman 1999). In this paper,...

SQL/SDA: A Query Language for Supporting Spatial Data Analysis and Its Web-Based Implementation (2001)

Hui Lin, Bo Huang

AbstractÐAn important trend of current GIS development is to provide easy and effective access to spatial analysis functionalities for supporting decision making based on geo-referenced data. Within...

Tripod: A Comprehensive Model for Spatial and Aspatial Historical Objects (2001)

Tony Griffiths, Norman W. Paton, Keith T. Mason, Bo Huang, Michael Worboys

Abstract Spatio-temporal extensions to data models have been an active area of research for a number of years. To date, much of this work has focused on the relational data model, with object data...

Properties of light mesons in a generalized Nambu-Jona-Lasinio model / (2000)

Huang, Bo.

"A dissertation submitted to the Graduate Faculty in Physics ... "

GeoVR: a web-based tool for virtual reality presentation from 2D GIS data (1999)

Bo Huang, Hui Lin

A tool called GeoVR has been designed and developed under a client/server architecture to enable the interactive creation of a 3D scene and virtual reality modeling language (VRML) model from 2D...

Identification of Novel Recognition Motifs and Regulatory Targets for the Yeast Actin-regulating Kinase Prk1p

Huang, Bo, Zeng, Guisheng, Ng, Alvin Y.J., Cai, Mingjie

Prk1p is a serine/threonine kinase involved in the regulation of the actin cytoskeleton organization in the yeast Saccharomyces cerevisiae. Previously, we have identified LxxQxTG as the...

An early step in wobble uridine tRNA modification requires the Elongator complex

HUANG, BO, JOHANSSON, MARCUS J.O., BYSTRÖM, ANDERS S.

Elongator has been reported to be a histone acetyltransferase complex involved in elongation of RNA polymerase II transcription. In Saccharomyces cerevisiae, mutations in any of the six Elongator...

The Kluyveromyces lactis γ-toxin targets tRNA anticodons

LU, JIAN, HUANG, BO, ESBERG, ANDERS, JOHANSSON, MARCUS J.O., BYSTRÖM, ANDERS S.

Kluyveromyces lactis killer strains secrete a heterotrimeric toxin (zymocin), which causes an irreversible growth arrest of sensitive yeast cells. Despite many efforts, the target(s) of the cytotoxic...

Funneled Landscape Leads to Robustness of Cell Networks: Yeast Cell Cycle

Wang, Jin, Huang, Bo, Xia, Xuefeng, Sun, Zhirong

We uncovered the underlying energy landscape for a cellular network. We discovered that the energy landscape of the yeast cell-cycle network is funneled towards the global minimum (G0/G1 phase) from...

Identification of Novel Recognition Motifs and Regulatory Targets for the Yeast Actin-regulating Kinase Prk1p

Huang, Bo, Zeng, Guisheng, Ng, Alvin Y.J., Cai, Mingjie

Prk1p is a serine/threonine kinase involved in the regulation of the actin cytoskeleton organization in the yeast Saccharomyces cerevisiae. Previously, we have identified LxxQxTG as the...

An early step in wobble uridine tRNA modification requires the Elongator complex

HUANG, BO, JOHANSSON, MARCUS J.O., BYSTRÖM, ANDERS S.

Elongator has been reported to be a histone acetyltransferase complex involved in elongation of RNA polymerase II transcription. In Saccharomyces cerevisiae, mutations in any of the six Elongator...

The Kluyveromyces lactis γ-toxin targets tRNA anticodons

LU, JIAN, HUANG, BO, ESBERG, ANDERS, JOHANSSON, MARCUS J.O., BYSTRÖM, ANDERS S.

Kluyveromyces lactis killer strains secrete a heterotrimeric toxin (zymocin), which causes an irreversible growth arrest of sensitive yeast cells. Despite many efforts, the target(s) of the cytotoxic...

Funneled Landscape Leads to Robustness of Cell Networks: Yeast Cell Cycle

Wang, Jin, Huang, Bo, Xia, Xuefeng, Sun, Zhirong

We uncovered the underlying energy landscape for a cellular network. We discovered that the energy landscape of the yeast cell-cycle network is funneled towards the global minimum (G0/G1 phase) from...

Nitric oxide controls nuclear export of APE1/Ref-1 through S-nitrosation of Cysteines 93 and 310

Qu, Jing, Liu, Guang-Hui, Huang, Bo, Chen, Chang

Apurinic/apyrimidinic endonuclease 1/redox effector factor-1 (APE1/Ref-1, abbreviated as APE1) is a molecule with dual functions in DNA repair and redox regulation of transcription factors....

Funneled Landscape Leads to Robustness of Cellular Networks: MAPK Signal Transduction

Wang, Jin, Huang, Bo, Xia, Xuefeng, Sun, Zhirong

We uncover the underlying potential energy landscape for a cellular network. We find that the potential energy landscape of the mitogen-activated protein-kinase signal transduction network is...

A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein

Whorton, Matthew R., Bokoch, Michael P., Rasmussen, Søren G. F., Huang, Bo, Zare, Richard N., Kobilka, Brian, ...

G protein-coupled receptors (GPCRs) respond to a diverse array of ligands, mediating cellular responses to hormones and neurotransmitters, as well as the senses of smell and taste. The structures of...

A conserved modified wobble nucleoside (mcm5s2U) in lysyl-tRNA is required for viability in yeast

Björk, Glenn R., Huang, Bo, Persson, Olof P., Byström, Anders S.

Transfer RNAs specific for Gln, Lys, and Glu from all organisms (except Mycoplasma) and organelles have a 2-thiouridine derivative (xm5s2U) as wobble nucleoside. These tRNAs read the A- and G-ending...

Scd5p Mediates Phosphoregulation of Actin and Endocytosis by the Type 1 Phosphatase Glc7p in Yeast

Zeng, Guisheng, Huang, Bo, Neo, Suat Peng, Wang, Junxia, Cai, Mingjie

Pan1p plays essential roles in both actin and endocytosis in yeast. It interacts with, and regulates the function of, multiple endocytic proteins and actin assembly machinery. Phosphorylation of...

Kluyveromyces lactis γ-toxin, a ribonuclease that recognizes the anticodon stem loop of tRNA

Lu, Jian, Esberg, Anders, Huang, Bo, Byström, Anders S.

Kluyveromyces lactis γ-toxin is a tRNA endonuclease that cleaves Saccharomyces cerevisiae tRNAmcm5s2UUCGlu3, tRNAmcm5s2UUULys and tRNAmcm5s2UUGGln between position 34 and position 35. All three...

Structure of the APPL1 BAR-PH domain and characterization of its interaction with Rab5

Zhu, Guangyu, Chen, Jia, Liu, Jay, Brunzelle, Joseph S, Huang, Bo, Wakeham, Nancy, ...

APPL1 is an effector of the small GTPase Rab5. Together, they mediate a signal transduction pathway initiated by ligand binding to cell surface receptors. Interaction with Rab5 is confined to the...

Eukaryotic Wobble Uridine Modifications Promote a Functionally Redundant Decoding System▿

Johansson, Marcus J. O., Esberg, Anders, Huang, Bo, Björk, Glenn R., Byström, Anders S.

The translational decoding properties of tRNAs are modulated by naturally occurring modifications of their nucleosides. Uridines located at the wobble position (nucleoside 34 [U34]) in eukaryotic...

Dynamic accessibility analysis in location-based service using an incremental parallel algorithm

Bo Huang, Qiang Wu

Accessibility analysis usually requires finding the closest facility within a certain category—for example, the nearest hotel, hospital, or gas station. Along with the development of location-based...

SCF-mediated mast cell infiltration and activation exacerbate the inflammation and immunosuppression in tumor microenvironment

Huang, Bo, Lei, Zhang, Zhang, Gui-Mei, Li, Dong, Song, Chuanwang, Li, Bo, ...

Despite the evidence for the role of inflammation in cancer initiation, promotion, and progression, the precise mechanism by which the inflammation within tumor is orchestrated by inflammatory cells...

A genome-wide screen identifies genes required for formation of the wobble nucleoside 5-methoxycarbonylmethyl-2-thiouridine in Saccharomyces cerevisiae

Huang, Bo, Lu, Jian, Byström, Anders S.

We recently showed that the γ-subunit of Kluyveromyces lactis killer toxin (γ-toxin) is a tRNA endonuclease that cleaves , , and 3′ of the wobble nucleoside 5-methoxycarbonylmethyl-2-thiouridine...

Land-use-change modeling using unbalanced support-vector machines

Bo Huang, Chenglin Xie, Richard Tay, Bo Wu

Modeling land-use change is a prerequisite to understanding the complexity of land-use-change patterns. This paper presents a novel method to model urban land-use change using support-vector machines...

Brd4 Coactivates Transcriptional Activation of NF-κB via Specific Binding to Acetylated RelA ▿

Huang, Bo, Yang, Xiao-Dong, Zhou, Ming-Ming, Ozato, Keiko, Chen, Lin-Feng

Acetylation of the RelA subunit of NF-κB, especially at lysine-310, is critical for the transcriptional activation of NF-κB and the expression of inflammatory genes. In this study, we demonstrate...

Regulation of HIF-1α and VEGF by miR-20b Tunes Tumor Cells to Adapt to the Alteration of Oxygen Concentration

Lei, Zhang, Li, Bo, Yang, Zhuoshun, Fang, Haoshu, Zhang, Gui-Mei, Feng, Zuo-Hua, ...

The regulation of HIF-1α is considered to be realized by pVHL-mediated ubiquitin-26S proteasome pathway at a post-transcriptional level. The discovery of a class of small noncoding RNAs, called...